Performance of CA125 in discriminating endometriosis cases from controls among participants presenting with dysmenorrhea in the adolescence to adulthood study.

Naoko Sasamoto (8049245), Mary DePari (9292346), Allison F. Vitonis (9292349), Marc R. Laufer (9292352), Stacey A. Missmer (4243072), Amy L. Shafrir (9292355), Kathryn L. Terry (8446431)
2020 · doi:10.1371/journal.pone.0238043.g001 · W6942071099
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This study evaluated the diagnostic performance of serum CA125 levels in distinguishing between adolescents and young adult women with surgically confirmed endometriosis and those without, specifically among participants presenting with dysmenorrhea. The researchers utilized receiver operating characteristic curves to assess the utility of standard cutoff values of 35 U/mL and 30 U/mL across varying pain severity levels, including mild, moderate, and severe symptoms. Results indicated that while CA125 showed some discriminatory ability, its performance varied significantly depending on the specific cutoff used and the intensity of the patient's pain. This paper is centrally about endometriosis — specifically analyzing the biomarker CA125 for diagnosing the condition in a symptomatic adolescent and young adult population.

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Abstract

(A) Receiver Operating Curves (ROC) using CA125 cutoff of 35 U/mL and (B) using CA125 cutoff of 30 U/mL among participants presenting with dysmenorrhea (overall = solid line; mild pain = dashed line; moderate pain = dotted line; severe pain = dash-dotted line).
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Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis Fig 1 Performance of CA125 in discriminating endometriosis cases from controls among participants presenting with dysmenorrhea in the adolescence to adulthood study. (A) Receiver Operating Curves (ROC) using CA125 cutoff of 35 U/mL and (B) using CA125 cutoff of 30 U/mL among participants presenting with dysmenorrhea (overall = solid line; mild pain = dashed line; moderate pain = dotted line; severe pain = dash-dotted line).

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endometriosisdysmenorrhea

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