Correlation Of SOX17, MACC1, c-Met With Clinicopathological Features And Prognosis of Esophageal Squamous Cell Carcinoma

Aim: We mainly investigated the relationship between the expression of SOX17, MACC1 and c-Met in esophageal squamous cell carcinoma and the clinicopathological parameters of the patients and the effect on prognosis. Methods: ：Expressions of SOX17, MACC1 and c-Met protein in a sample of 232 ESCC and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationships and correlations with clinicopathological features and clinical prognosis were analyzed by SPSS 23.0. Results: ： SOX17 was associated with Vascular invasion ( p =0.017) and Nerve invasion ( p =0.014). MACC1 was correlated with Tumor size ( p =0.039) and TNM stage ( p =0.020).c-Met was significantly associated with hematogenous metastasis ( p =0.045). The expression of MACC1 was correlated with c-Met (P<0.001). c-Met expression( p =0.021) were associated with OS. Conclusion: SOX17, MACC1 and c-Met may be new diagnostic targets for esophageal squamous cell carcinoma. c-Met may be a new therapeutic and prognostic target.