Lycium barbarum polysaccharide alleviates neurobehavioral deficits in mice with ischemic cerebral injury

2025 · doi:10.1101/2025.06.13.659653
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The study investigated whether Lycium barbarum polysaccharides (LBP) could improve neurobehavioral impairments in a mouse model of ischemic cerebral injury, using transient middle cerebral artery occlusion (MCAO) followed by ischemia-reperfusion. Mice were assigned to sham, I/R, or I/R plus LBP groups, and neurobehavior was assessed with Y-maze, rotarod, and balance beam tests, while peripheral pro-inflammatory cytokines TNF-α and IL-6 were measured by ELISA alongside evaluations of inflammatory and oxidative stress. LBP significantly ameliorated neuroinflammation and oxidative stress after I/R and improved motor and memory deficits relative to the I/R group. The paper does not explicitly state limitations in the provided text, but it focuses on a cerebral ischemia context rather than detailing mechanisms beyond attenuation of inflammatory responses. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Objective To investigate the effects of Lycium barbarum polysaccharides (LBP) on neurobehavioral impairments in mice with ischemic stroke and explore the underlying mechanisms. Methods A middle cerebral artery occlusion (MCAO) model was established using the filament occlusion method to evaluate the therapeutic effects of LBP on pathological brain tissue damage after cerebral ischemia-reperfusion injury (I/R). Mice were randomly divided into three groups: sham surgery (Sham), I/R, and I/R + LBP. Behavioral tests, including the Y-maze test, rotarod test, and balance beam test, were systematically conducted to assess the impact of LBP on neurobehavioral impairments. Enzyme-linked immunosorbent assay (ELISA) was used to quantify peripheral blood levels of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), reflecting inflammatory status. Results LBP significantly ameliorated neuroinflammation and oxidative stress in mice with cerebral I/R injury, demonstrating marked protection against I/R-induced neurofunctional damage. LBP notably improved motor and memory deficits caused by ischemic stroke. Compared to the I/R group, LBP improved neuroinflammation and oxidative stress levels post-I/R injury. Conclusion This study demonstrates that LBP alleviates ischemic stroke-induced neurological damage by attenuating inflammatory responses.
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Abstract

Objective To investigate the effects of Lycium barbarum polysaccharides (LBP) on neurobehavioral impairments in mice with ischemic stroke and explore the underlying mechanisms.

Methods

A middle cerebral artery occlusion (MCAO) model was established using the filament occlusion method to evaluate the therapeutic effects of LBP on pathological brain tissue damage after cerebral ischemia-reperfusion injury (I/R). Mice were randomly divided into three groups: sham surgery (Sham), I/R, and I/R + LBP. Behavioral tests, including the Y-maze test, rotarod test, and balance beam test, were systematically conducted to assess the impact of LBP on neurobehavioral impairments. Enzyme-linked immunosorbent assay (ELISA) was used to quantify peripheral blood levels of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), reflecting inflammatory status.

Results

LBP significantly ameliorated neuroinflammation and oxidative stress in mice with cerebral I/R injury, demonstrating marked protection against I/R-induced neurofunctional damage. LBP notably improved motor and memory deficits caused by ischemic stroke. Compared to the I/R group, LBP improved neuroinflammation and oxidative stress levels post-I/R injury.

Conclusion

This study demonstrates that LBP alleviates ischemic stroke-induced neurological damage by attenuating inflammatory responses. Competing Interest Statement The authors have declared no competing interest. Abbreviations - LB - Lycium barbarum - I/R - ischemia/reperfusion injury - MCAO - transient middle cerebral artery occlusion - ICA - internal carotid artery - MCA - middle cerebral artery - mNss - modified neurological severity score - OFT - open field test

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