Clinical characteristics of late recurrence in granulosa cell tumor of ovary

Objective: To explore the clinical features and treatment of 22 patients with recurrent ovarian granulosa cell tumor (GCT). Methods: : The clinical data of 22 females with recurrent ovarian GCT and received treatments in Qilu hospital were retrospectively analyzed. Results: During the recurrence interval, late recurrence (≥5 years) appeared in 14 patients, early recurrence (<5 years) were in 8 patients. Among the 22 recurrent patients, 8 cases had second relapses during the time of follow-up. Of the 14 late recurrent cases, 10 cases had FIGO stage Ⅰ cancers, 4 had stage Ⅲ cancers. Among the 8 early recurrent GCT cases, 5 had FIGO stage Ⅰ cancers. FIGO stage and whether performed fertility-sparing surgery or not had significant impacts on the recurrence type (P =0.035 and 0.016, respectively). Conclusions: : The intervals of GCT recurrence are usually long after the initial diagnosis. Continuous long-term follow-up is absolutely required, especially for those with early stage and complete surgery.