Importance of Serum Copper and Vascular Endothelial Growth Factor (VEGF-A) Levels in Postmenopausal Bleeding

Afshan Rafi, Rafi A, Ramakrishna Devaki, Devaki R, Sabitha K, K. Sabitha, Shruti Mohanty, Mohanty S, Pragna Rao
Indian journal of clinical biochemistry : IJCB · 2012 · vol. 28(2) , pp. 147–151 · doi:10.1007/s12291-012-0240-9 · PMID:24426200 · PMC3613505 · W2071303267
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This study found that postmenopausal bleeding patients exhibit significantly elevated serum copper and VEGF-A levels, which correlate with increased endometrial thickness and may drive abnormal angiogenesis.

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Abstract

The main aim of this study is association of serum copper and vascular endothelial growth factor (VEGF-A) in postmenopausal bleeding (PMB) patients. Blood samples were collected from female patients suffering with postmenopausal bleeding (n = 50) as well as healthy females as controls (n = 50). Serum copper levels were estimated by spectrophotometric method and serum VEGF-A by ELISA technique and compared with ultrasonographic measurement of endometrial thickness in both patients and controls. A significant increase in serum copper levels and an almost twofold increase in serum VEGF-A was observed in DUB patients when compared with controls. Correlation (r) between serum VEGF-A levels and endometrial thickness was 0.96. Odds ratio for copper, VEGF-A and combination of copper and VEGF-A was 0.0426, 0.0947 and 0.0313 respectively, in all these cases odds ratio was <1. The abnormal angiogenesis in PMB could be due to increased serum copper levels,which in turn stimulates factors like VEGF-A, thereby causing an increase in endometrial growth.

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