Mechanical properties and constitutive modeling of the human arteriovenous fistula aneurysm

Mechanical properties and constitutive modeling of the human arteriovenous fistula aneurysm | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Mechanical properties and constitutive modeling of the human arteriovenous fistula aneurysm Zbyněk Sobotka, Lukáš Horný, Nikola Petrová, Karel Filip, Jiří Urban, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8483215/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The arteriovenous fistula (AVF), a surgically created connection between an artery and a vein, remains the gold standard for vascular access in patients undergoing chronic hemodialysis. The fistula is most commonly created on the upper limb, where, for example, the cephalic vein and radial or brachial artery can be used. Although AVF is the most common method used for vascular access in hemodialysis, its performance remains vulnerable to multiple sources of potential failure. An arteriovenous fistula aneurysm (AVFA) in particular is one of the most common pathologies that develops in the vein segment of the anastomosis. The causes leading to AVFA formation are not yet fully understood, nevertheless both the remodeling process and tissue scarring induced by repeated cannulation of the vein contribute to its development. With this study, we wish to contribute to expanding our knowledge of AVFA biomechanics. Samples of healthy cephalic veins and aneurysmatic AVFs were collected from human donors. Uniaxial tensile tests in two perpendicular directions were carried out to determine their mechanical response. A significant decrease in the initial Young’s elastic modulus and anisotropy was observed in the AVFA group. Histological analysis of the samples showed a degradation of the elastic component and a disorganization of the collagen and VSMC. A 4-fiber-family hyperelastic anisotropic constitutive model of the exponential type was used in the nonlinear regression of the experimental data. The resulting constitutive models led to a good correspondence between the data and predictions. The obtained estimates of the constitutive parameters can be used in future fluid-structure interaction analyses aimed at computational simulations of AVF and AVFA hemodynamics. Health sciences/Diseases Physical sciences/Engineering Health sciences/Medical research Arteriovenous fistula aneurysm biomechanics constitutive model histology tensile test Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8483215","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":569514980,"identity":"4c9af528-3807-486b-be98-9df136774e49","order_by":0,"name":"Zbyněk Sobotka","email":"","orcid":"","institution":"Czech Technical University in Prague","correspondingAuthor":false,"prefix":"","firstName":"Zbyněk","middleName":"","lastName":"Sobotka","suffix":""},{"id":569514981,"identity":"b0475dc9-0e84-4d0e-a735-e6dd433a8e13","order_by":1,"name":"Lukáš 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aneurysm","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Arteriovenous fistula, aneurysm, biomechanics, constitutive model, histology, tensile test","lastPublishedDoi":"10.21203/rs.3.rs-8483215/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8483215/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe arteriovenous fistula (AVF), a surgically created connection between an artery and a vein, remains the gold standard for vascular access in patients undergoing chronic hemodialysis. The fistula is most commonly created on the upper limb, where, for example, the cephalic vein and radial or brachial artery can be used. Although AVF is the most common method used for vascular access in hemodialysis, its performance remains vulnerable to multiple sources of potential failure. An arteriovenous fistula aneurysm (AVFA) in particular is one of the most common pathologies that develops in the vein segment of the anastomosis. The causes leading to AVFA formation are not yet fully understood, nevertheless both the remodeling process and tissue scarring induced by repeated cannulation of the vein contribute to its development. With this study, we wish to contribute to expanding our knowledge of AVFA biomechanics. Samples of healthy cephalic veins and aneurysmatic AVFs were collected from human donors. Uniaxial tensile tests in two perpendicular directions were carried out to determine their mechanical response. A significant decrease in the initial Young\u0026rsquo;s elastic modulus and anisotropy was observed in the AVFA group. Histological analysis of the samples showed a degradation of the elastic component and a disorganization of the collagen and VSMC.\u003c/p\u003e \u003cp\u003eA 4-fiber-family hyperelastic anisotropic constitutive model of the exponential type was used in the nonlinear regression of the experimental data. The resulting constitutive models led to a good correspondence between the data and predictions. The obtained estimates of the constitutive parameters can be used in future fluid-structure interaction analyses aimed at computational simulations of AVF and AVFA hemodynamics.\u003c/p\u003e","manuscriptTitle":"Mechanical properties and constitutive modeling of the human arteriovenous fistula aneurysm","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-01-06 10:17:02","doi":"10.21203/rs.3.rs-8483215/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"844b873d-9553-400b-86bb-c49b5e2d2df4","owner":[],"postedDate":"January 6th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":60597114,"name":"Health sciences/Diseases"},{"id":60597115,"name":"Physical sciences/Engineering"},{"id":60597116,"name":"Health sciences/Medical research"}],"tags":[],"updatedAt":"2026-04-01T08:58:51+00:00","versionOfRecord":[],"versionCreatedAt":"2026-01-06 10:17:02","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8483215","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8483215","identity":"rs-8483215","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}