Associations of a SHROOM3 variant with mild renal impairment and depressive symptoms in a Chinese Han population

Abstract Background: To explore the associations of several genetic variants identified in the genome-wide association studies (GWAS) of European ancestry with mild renal impairment glomerular filtration rate (GFR) in Chinese Han population.Methods: Data of 1788 community-dwelling elders from the baseline survey of the ageing arm of the Rugao Longevity and Ageing Study was used. Plasma creatinine based GFR was estimated using the eGFR-EPI equations.Results: Of the 10 common polymorphisms identified in GWAS of the European ancestry, rs17319721 located in the first intron of the SHROOM3, was associated with GFR. A allele was associated with both decreased GFR level and greater odds of mild renal impairment (OR 1.12, 95% CI 1.01-1.23, p=0.029) defined by GFR<90 mL/min/1.73 m2 after adjusting for multiple confounds of chronic kidney disease. In addition, compared with rs17319721-GG genotype, AA was associated with both higher depressive score and greater risk of depression prevalence, showing a pleiotropic effects of rs17319721. However, we did not found significant association of GFR levels with another 42 common polymorphisms that was previously reported to be associated with the traditional risk factors of kidney diseases.Conclusions: SHROOM3-rs17319721 is associated with GFR levels, kidney impairment, and depressive symptoms in a Chinese population.