A temperature, pH, and ion sensitive block copolymer  with an unusual phase transition:  Monomethoxy polyethylene glycol - block-polyethyleneimine

A temperature, pH, and ion sensitive block copolymer with an unusual phase transition: Monomethoxy polyethylene glycol - block-polyethyleneimine | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A temperature, pH, and ion sensitive block copolymer with an unusual phase transition: Monomethoxy polyethylene glycol - block-polyethyleneimine KADRİYE ÖZLEM HAMALOĞLU, Hacim Kosaoğlu, Ali Tuncel, Serdar S. Çelebi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4643339/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 26 Oct, 2024 Read the published version in Journal of Polymer Research → Version 1 posted 5 You are reading this latest preprint version Abstract A temperature, pH and ion sensitive, block copolymer, monomethoxypolyethylene glycol (MPEG)–block-polyethyleneimine (PEI) was synthesized by carbodimide activation. MPEG-PEI block copolymer exhibited a thermally reversible phase transition from insoluble to soluble form with increasing temperature at neutral pH. MPEG-PEI chains are insoluble in the temperature range of 4-20oC in an aqueous medium containing 3.5 mM phosphate ion. By increasing temperature, homogeneous and transparent solutions including dissolved copolymer are obtained at temperatures higher than 20oC. The observed thermoresponsive behavior was opposite to that seen with poly(N-isopropylacrylamide). Depending on the phosphate ion concentration, the phase transition temperature for passing from insoluble to soluble form could be also precisely controlled between 4-40oC. The reversible phase transition behavior of MPEG-PEI copolymer was confirmed by ten consecutive heating-cooling cycles between 4 - 50oC. MPEG-PEI copolymer also exhibited another responsivity against pH. More appreciable increase in the average hydrodynamic size with the rising temperature was observed at pH 9.0 with respect to those obtained at pH 5 and 7. Temperature, pH and ion sensitive behavior of MPEG-PEI is documented for the first time. The reversible phase transition of MPEG-PEI is a promising tool which may open novel pathways, particularly for enzyme immobilization and drug release studies. Stimuli-responsive polymer Temperature sensitive polymer pH responsive polymer Phase transition Polyethylene glycol Polyethyleneimine Full Text Cite Share Download PDF Status: Published Journal Publication published 26 Oct, 2024 Read the published version in Journal of Polymer Research → Version 1 posted Reviewers agreed at journal 07 Jul, 2024 Reviewers invited by journal 07 Jul, 2024 Editor invited by journal 03 Jul, 2024 Editor assigned by journal 27 Jun, 2024 First submitted to journal 27 Jun, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4643339","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":323625359,"identity":"b1f8b29c-b882-4904-beb5-446b05308196","order_by":0,"name":"KADRİYE ÖZLEM HAMALOĞLU","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABDUlEQVRIiWNgGAWjYFAC5gYwxS+BLMiDVwsjRIvkDBCZYADXIoFLA1yLwQ1itfDzH2x8dHOHnb3x7eaHHz7++CNnzt7A+OBtG0OdeQN2LZINB5uNc88kM5vdOWYsOSPBwNiy5wCz4dw2BgmZA9i1GBxsbJPObWNmM7uRYMbMk2CQuOFGAps0L1ALLpcZHGZs/53bVs9jPCP9G/OfBIP6DfcfsP/Gq+UYYxtzbtthCQOJHDNmoPcTgOHAxoxPi2QPYzPQYccNJG7kFEv2pBkb7uxJbJacc04CEupYQ+zwwc+5bdX2/DPSN374YSMnb85++OCHN2U2/HgiBt2pkJgiXgNIyygYBaNgFIwCVAAAmuhTY2RDy94AAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0001-8170-762X","institution":"Hacettepe University: Hacettepe Universitesi","correspondingAuthor":true,"prefix":"","firstName":"KADRİYE","middleName":"ÖZLEM","lastName":"HAMALOĞLU","suffix":""},{"id":323625360,"identity":"97e4c1bd-7b00-45e1-a04d-8ca951234d49","order_by":1,"name":"Hacim Kosaoğlu","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Hacim","middleName":"","lastName":"Kosaoğlu","suffix":""},{"id":323625361,"identity":"f0a49602-be4a-42ef-8a3a-b234cf5973ad","order_by":2,"name":"Ali Tuncel","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Ali","middleName":"","lastName":"Tuncel","suffix":""},{"id":323625362,"identity":"772076c8-c0e2-4f95-8127-0e92b4ad6bab","order_by":3,"name":"Serdar S. 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