Tailored piezoelectric chitosan thin film for ultrasound-controlled drug delivery

Tailored piezoelectric chitosan thin film for ultrasound-controlled drug delivery | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Tailored piezoelectric chitosan thin film for ultrasound-controlled drug delivery Gaia de Marzo, Valentina Antonaci, Virgilio Brunetti, Laura Blasi, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7544848/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Although oral drug delivery represents the most employed route because of its ease, its efficacy is limited by low drug bioavailability due to gastric passage and possible systemic toxicity. Hence, it is crucial to develop stimuli-responsive materials that precisely control the position and time of the delivery of drugs for targeted administration and reduced side effects. To this aim, we developed an ultrasound-sensitive thin, biocompatible and sustainable piezoelectric chitosan film, which can be wirelessly activated by ultrasound, opening the possibility of controlled release in deep body compartments. We developed a protocol to easily tailor the properties of the film by embedding different molecules without compromising its piezoelectric behavior and to release, in a controlled on/off manner, more than 80% of the drug in less than 3 hours. The material´s potential was demonstrated with Doxorubicin, an antineoplastic agent against colon cancer, paving the way for enhanced and on-demand intestinal drug release. Physical sciences/Materials science/Biomaterials/Drug delivery Physical sciences/Materials science/Materials for devices/Electronic devices Full Text Additional Declarations There is NO Competing Interest. Supplementary Files SupplementariesdeMarzo.docx Supplementary figure Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7544848","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":512101574,"identity":"a8d1b59b-caf8-4788-9006-d007f5ce3d64","order_by":0,"name":"Gaia de 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