Expression correlation of ER to PR,cerbB-2 genes, and Bcl-2 in adenomyosis uterus

Objective To investigate the expression of ER,PR,cerbB-2 and Bcl-2 in adenomyosis and their correlation with pathogenesis. Methods The expressions of ER, PR, cerbB-2,and Bcl-2 in 40 cases of adenomyosis were assayed by En Vision immunohistochemical methods. Results The positive rates of ER,PR, cerbB-2 and Bcl-2 protein in ectopic endometrium of myometrium were 97.5%,97.5%, 82.5% and 62. 5 % , respectively. Both the eutopic and ectopic endometrium in 40 cases showed ER,PR positive. The positive expression rate had no significant differences(P0.05). The strong positive rate of cerbB-2 in the cetopic endometrium was significantly higher than that eutopic in the(P0.05).The expression of ER,and PR had a positive correlation with the expression of cerbB-2,and Bcl-2(P0.05). Conclusion ER,PR,cerbB-2 and Bcl-2 are overexpresscd in the eutopic and ectopic endometrium. They play important roles in the progression of adenomyosis.