Diagnostic Accuracy of Ultrasound-Guided Core Needle Biopsy Versus Incisional Biopsy in Soft Tissue Sarcoma: An Institutional Experience.

Diagnostic Accuracy of Ultrasound-Guided Core Needle Biopsy Versus Incisional Biopsy in Soft Tissue Sarcoma: An Institutional Experience. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Diagnostic Accuracy of Ultrasound-Guided Core Needle Biopsy Versus Incisional Biopsy in Soft Tissue Sarcoma: An Institutional Experience. Miroslava Cernakova, Gerhard Martin Hobusch, Gabriele Amann, Philipp Theodor Funovics, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-442014/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 11 You are reading this latest preprint version Abstract Background Core needle biopsy (CNB) is gaining in importance due to its advantages in the matter of patient morbidity, time and cost. Nevertheless, controversies still exist regarding the biopsy technique of choice for the accurate diagnosis of soft tissue sarcoma (STS). This study compared the diagnostic performance between ultrasound-guided CNB and incisional biopsy (IB), both performed by orthopedic surgeons. Questions/purposes The aims of the study were to answer the following questions: (1) Is ultrasound-guided CNB a highly reliable modality for diagnosing STSs? (2) Is CNB equally useful to IB for identifying histologic subtype? (3) Had patients who underwent CNB a reduced risk of complications? Methods One-hundred and seventy-five patients who underwent resection of soft tissue sarcoma were classified into two groups according to biopsy technique prior to surgery; CNB group (n=109) and IB group (n=66). The final surgical specimens were in 62 patients liposarcoma, 39 undifferentiated pleomorphic sarcoma (UPS), 33 myxofibrosarcoma, 10 synovial sarcoma, 10 leiomyosarcoma and in the remaining 21 patients different soft tissue sarcoma entities. Sarcoma location of 90 patients was in the thigh, 21 in the lower leg, 22 in the upper arm and shoulder area; 10 in each the knee, gluteal and thoracic region, the residual 12 in other body areas. Results Malignancy was correctly diagnosed in 86% (94 of 109) for the CNB group and 91% (60/66) for the IB group. Correct identification rate of histologic subtype was 80% (87 of 109) in the CNB group and 82% (54 of 66) in the IB group. There were no significant differences in the correct diagnosis rates of malignancy and subtype between the two techniques. No complications were seen in the CNB group, whereas 2 patients in whom IB was performed developed pulmonary embolism and 1 patient surgical site infection. Conclusions Ultrasound-guided CNB is highly accurate and not inferior to IB in diagnosing the dignity of lesions and histologic subtype in patients with suspected STSs. Orthopedic Surgery Oncology Core needle biopsy (CNB) Soft Tissue Sarcoma (STS) Diagnostic Accuracy Incisional Biopsy Institutional Experience Ultrasound-Guided Figures Figure 1 Full Text Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Major revision 13 Jul, 2021 Reviews received at journal 06 Jul, 2021 Reviewers agreed at journal 28 Jun, 2021 Reviews received at journal 24 May, 2021 Reviewers agreed at journal 11 May, 2021 Reviewers agreed at journal 11 May, 2021 Reviewers invited by journal 09 May, 2021 Editor assigned by journal 06 May, 2021 Editor invited by journal 22 Apr, 2021 Submission checks completed at journal 22 Apr, 2021 First submitted to journal 20 Apr, 2021 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-442014","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":22679490,"identity":"c315391f-6241-4d7c-8332-ed57d5b4259a","order_by":0,"name":"Miroslava Cernakova","email":"","orcid":"","institution":"Medical University of Vienna","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Miroslava","middleName":"","lastName":"Cernakova","suffix":""},{"id":22679491,"identity":"0d1cc7fa-d22f-4c5d-82cf-b951a2308d02","order_by":1,"name":"Gerhard Martin Hobusch","email":"data:image/png;base64,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","orcid":"","institution":"Medical University of Vienna","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Gerhard","middleName":"Martin","lastName":"Hobusch","suffix":""},{"id":22679492,"identity":"15ef649d-ea02-4947-91fd-424f53925a94","order_by":2,"name":"Gabriele Amann","email":"","orcid":"","institution":"Medical University of Vienna","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Gabriele","middleName":"","lastName":"Amann","suffix":""},{"id":22679493,"identity":"299a1b94-8317-48bc-992f-da42559a4afa","order_by":3,"name":"Philipp Theodor Funovics","email":"","orcid":"","institution":"Medical University of Vienna","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Philipp","middleName":"Theodor","lastName":"Funovics","suffix":""},{"id":22679494,"identity":"857db3d4-e89d-495c-818c-b3f3b290912d","order_by":4,"name":"Reinhard Windhager","email":"","orcid":"","institution":"Medical University of Vienna","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Reinhard","middleName":"","lastName":"Windhager","suffix":""},{"id":22679495,"identity":"390df591-955b-410b-9f73-b1e04bbc6720","order_by":5,"name":"Joannis Panotopoulos","email":"","orcid":"","institution":"Medical University of Vienna","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Joannis","middleName":"","lastName":"Panotopoulos","suffix":""}],"badges":[],"createdAt":"2021-04-20 08:29:08","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-442014/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-442014/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":8372067,"identity":"4e1099b6-cefd-4fc3-9bd8-e7061561160c","added_by":"auto","created_at":"2021-04-23 14:21:36","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":159299,"visible":true,"origin":"","legend":"This graphic shows the elimination of patients.","description":"","filename":"Fig1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-442014/v1/5fa80541ea9c422afad48ab4.jpg"},{"id":13624531,"identity":"c66d1074-1337-495e-a7d4-8aa4631567c1","added_by":"auto","created_at":"2021-09-17 07:22:56","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":447781,"visible":true,"origin":"","legend":"","description":"","filename":"stsbxmanuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-442014/v1_covered.pdf"},{"id":8372678,"identity":"8ade3c74-215e-497b-bb4a-ecead8c5812e","added_by":"auto","created_at":"2021-04-23 14:24:44","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":483469,"visible":true,"origin":"","legend":"","description":"","filename":"stsbxmanuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-442014/v1_stamped.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Diagnostic Accuracy of Ultrasound-Guided Core Needle Biopsy Versus Incisional Biopsy in Soft Tissue Sarcoma: An Institutional Experience.","fulltext":[{"header":"Full Text","content":"\u003cp\u003eDue to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.\u003c/p\u003e "}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Core needle biopsy (CNB), Soft Tissue Sarcoma (STS), Diagnostic Accuracy, Incisional Biopsy, Institutional Experience, Ultrasound-Guided","lastPublishedDoi":"10.21203/rs.3.rs-442014/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-442014/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cem\u003eBackground \u003c/em\u003e\u003c/p\u003e\u003cp\u003eCore needle biopsy (CNB) is gaining in importance due to its advantages in the matter of patient morbidity, time and cost. Nevertheless, controversies still exist regarding the biopsy technique of choice for the accurate diagnosis of soft tissue sarcoma (STS). This study compared the diagnostic performance between ultrasound-guided CNB and incisional biopsy (IB), both performed by orthopedic surgeons.\u0026nbsp;\u003c/p\u003e\u003cp\u003e\u003cem\u003eQuestions/purposes\u003c/em\u003e\u003c/p\u003e\u003cp\u003eThe aims of the study were to answer the following questions: (1) Is ultrasound-guided CNB a\u0026nbsp;highly reliable modality for diagnosing STSs? (2) Is CNB equally useful to IB for identifying histologic subtype?\u0026nbsp;(3) Had patients who underwent CNB a reduced risk of complications? \u003c/p\u003e\u003cp\u003e\u003cem\u003eMethods\u003c/em\u003e\u003c/p\u003e\u003cp\u003eOne-hundred and seventy-five patients who underwent resection of soft tissue sarcoma were classified into two groups according to biopsy technique prior to surgery; CNB group (n=109) and IB group (n=66). The final surgical specimens were in 62 patients liposarcoma, 39 undifferentiated pleomorphic sarcoma (UPS), 33 myxofibrosarcoma, 10 synovial sarcoma, 10 leiomyosarcoma and in the remaining 21 patients different soft tissue sarcoma entities. Sarcoma location of 90 patients was in the thigh, 21 in the lower leg, 22 in the upper arm and shoulder area; 10 in each the knee, gluteal and thoracic region, the residual 12 in other body areas.\u0026nbsp;\u0026nbsp;\u003c/p\u003e\u003cp\u003e\u003cem\u003eResults \u003c/em\u003e\u003c/p\u003e\u003cp\u003eMalignancy was correctly diagnosed in 86% (94 of 109) for the CNB group and 91% (60/66) for the IB group. Correct identification rate of histologic subtype was 80% (87 of 109) in the CNB group and 82% (54 of 66) in the IB group. There were no significant differences in the correct diagnosis rates of malignancy and subtype between the two techniques.\u0026nbsp;No complications were seen in the CNB group, whereas 2 patients in whom IB was performed developed pulmonary embolism and 1 patient surgical site infection.\u0026nbsp;\u003c/p\u003e\u003cp\u003e\u003cem\u003eConclusions \u003c/em\u003e\u003c/p\u003e\u003cp\u003eUltrasound-guided CNB is highly accurate and not inferior to IB in diagnosing the dignity of lesions and histologic subtype in patients with suspected STSs.\u003c/p\u003e","manuscriptTitle":"Diagnostic Accuracy of Ultrasound-Guided Core Needle Biopsy Versus Incisional Biopsy in Soft Tissue Sarcoma: An Institutional Experience.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-04-23 14:21:35","doi":"10.21203/rs.3.rs-442014/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2021-07-13T05:54:46+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-07-06T12:27:53+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"0f99604f-b6d7-4e27-9ca8-5ecbb70add96","date":"2021-06-28T06:26:34+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-05-24T09:40:49+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"f5e0a132-297d-4df7-b3db-22277aaa3e9a","date":"2021-05-11T21:42:13+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"b0216011-ecef-470f-b662-48bb5b9b958a","date":"2021-05-11T05:26:24+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2021-05-09T15:17:34+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2021-05-06T10:22:27+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2021-04-22T14:59:50+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2021-04-22T10:18:31+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2021-04-20T08:18:30+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"e8b970de-3552-4b79-a973-640f317d3d09","owner":[],"postedDate":"April 23rd, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":3856351,"name":"Orthopedic Surgery"},{"id":3856352,"name":"Oncology"}],"tags":[],"updatedAt":"2021-08-09T09:29:05+00:00","versionOfRecord":[],"versionCreatedAt":"2021-04-23 14:21:35","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-442014","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-442014","identity":"rs-442014","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}