Role of Progestins in Reproduction

Godspower Onyeso, Japheth David, J. H. M. David, Michael Egwu, Menizibeya Welcome
In: Sex Steroid Hormones - Impact on Reproductive Physiology · 2024 · doi:10.5772/intechopen.1007931 · W4405332125
book-chapter OA: hybrid CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper details the development, classification, and multifaceted roles of progestins in regulating menstruation, pregnancy, ovulation, birth control, endometriosis, HRT, and ART, highlighting their effectiveness in reproductive health applications.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Progestins are artificial derivatives of the naturally occurring steroid progesterone and include most if not all, aspects of reproductive physiology and medicine. The functions of progestins are established in regulating menstruation, sustaining pregnancy, and treating infertility. This chapter provides detailed insights into the development, mechanism of action, classification of progestins, and their diverse roles in reproduction, with a particular focus on their roles in menstruation, ovulation, pregnancy, birth control, endometriosis, hormonal replacement therapy (HRT), and assisted reproductive technology (ART). The main discoveries indicate that progestins effectively control menstrual cycles, prevent premature ovulation, and facilitate the early maintenance of pregnancy. In contraceptive applications, they successfully inhibit ovulation and alter endometrial receptivity to prevent pregnancy. In treating endometriosis, progestins induce atrophy of endometrial lesions, providing significant symptom relief. In hormone replacement therapy (HRT), the effects of estrogen are regulated to alleviate symptoms of menopause and reduce the risk of endometrial hyperplasia. For ART, progestins enhance the conditions for successful embryo transfer and improve fertility outcomes. The overall recommendation is to continue progestin research to optimize their use in reproductive health, improve treatment protocols, and enhance patient outcomes, as that will help enhance the field of reproductive medicine.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (72)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK