Coincidence of uterine malformations and endometriosis: a clinically relevant problem?

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This retrospective study found a high prevalence of endometriosis in women with uterine malformations, suggesting it should be specifically screened for in these patients.

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This retrospective study evaluated 279 patients admitted to a single hospital between 01.12.2014 and 30.11.2019 to determine whether women with uterine malformations had a higher prevalence of histologically confirmed endometriosis (peritoneal, ovarian, or deep infiltrating). Among the cohort, 94.2% had non-obstructive uterine malformations and 4.3% had obstructive malformations; overall, 74.9% had endometriosis, including additional deep infiltrating lesions in 27 cases. The authors conclude that endometriosis is highly prevalent in this setting and state as a limitation that, being retrospective and hospital-based, the data rely on this admitted population rather than a population-based sample. This paper is centrally about endometriosis — it investigates the coincidence of uterine malformations with endometriosis and reports a high endometriosis prevalence in women with these anomalies.

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Abstract

INTRODUCTION: It is suspected that uterine malformations and endometriosis have a high coincidence. Furthermore, it is expected that obstructive uterine malformations are significantly higher affected than non-obstructive malformations. The correlation between endometriosis and uterine malformations may be due to increased retrograde menstruation, which would explain a higher coincidence of obstructive malformations and endometriosis [14]. METHODS: This retrospective study investigates whether patients with uterine malformations have a higher prevalence of endometriosis. The study includes patients with uterine malformations who were admitted to our hospital in the period from 01.12.2014 to 30.11.2019. RESULTS: 279 cases were analysed. 263 (94.2%) patients had a non-obstructive uterine malformation, 12 (4.3%) patients had an obstructive uterine malformation and 4 (1.4%) patients had uterine agenesia/hypoplasia. 209 (74.9%) patients had histologically confirmed endometriosis (peritoneal, ovarian or deep infiltrating) and 70 (25.1%) had no endometriosis. In 27 cases, deep infiltrating endometriosis (ENZIAN ABC) was detected additionally to peritoneal and ovarian endometriosis. CONCLUSION: The study shows a high prevalence of endometriosis in women with uterine malformations. For this reason, endometriosis should always be specifically sought in uterine malformations.
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Abstract

Introduction It is suspected that uterine malformations and endometriosis have a high coincidence. Furthermore, it is expected that obstructive uterine malformations are significantly higher affected than non-obstructive malformations. The correlation between endometriosis and uterine malformations may be due to increased retrograde menstruation, which would explain a higher coincidence of obstructive malformations and endometriosis [14].

Methods

This retrospective study investigates whether patients with uterine malformations have a higher prevalence of endometriosis. The study includes patients with uterine malformations who were admitted to our hospital in the period from 01.12.2014 to 30.11.2019.

Results

279 cases were analysed. 263 (94.2%) patients had a non-obstructive uterine malformation, 12 (4.3%) patients had an obstructive uterine malformation and 4 (1.4%) patients had uterine agenesia/hypoplasia. 209 (74.9%) patients had histologically confirmed endometriosis (peritoneal, ovarian or deep infiltrating) and 70 (25.1%) had no endometriosis. In 27 cases, deep infiltrating endometriosis (ENZIAN ABC) was detected additionally to peritoneal and ovarian endometriosis.

Conclusion

The study shows a high prevalence of endometriosis in women with uterine malformations. For this reason, endometriosis should always be specifically sought in uterine malformations. Similar content being viewed by others

References

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Outcome instruments

Enzian

Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Infertility, Female Urogenital Abnormalities Uterus Adult Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Prevalence Retrospective Studies Urogenital Abnormalities Urogenital Abnormalities Uterus

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