Analysis of Fundus Photography and Fluorescein Angiography in Chinese patients with different stages of non-arteritic anterior inschemic optic neuropathy

ABSTRACT Purpose: The aim of this study was to characterize the different stages of non-arteritic anterior inschemic optic neuropathy (NAION) features by Fundus Photography (FP) and Fluorescein Aniography (FA) in a Chinese Population. Methods: The retrospective observation study included 30 patients (36 eyes) with acute phase, 20 patients (27 eyes) with subacute phase and 30 patients (52 eyes) with chronic phase. Macular, optic nerve and disc were investigated by FP and FA. Categorical variables were evaluated by Fisher’s exact test. Results: Macular edema, papilloedema, disc hemorrhage and exudation from FP were more common in the acute and subacute stage groups than chronic stage group with optic atrophy in contrast (all p<0.01). Compared to chronic stage, acute and subacute stages were more likely to appear macular fluorescence accumulation and peripapillary choroid filling delay (all p<0.01). However, chronic stage tended to have retinal artery filling delay and disc filling defects in the early phase from FA (all p<0.01). Conclusion: The data showed that NAION had different fundus performances at different clinical stages. They may help to record the disease progression for accurate diagnosis and treatment.