Clinical observation of Triptorelin and Leuprorelin on treatment of endometriosis postoperative adverse symptoms

Objective To compare the side effects and decrease of hormone level in the treatment of endometriosis(EMs) using Triptorelin and Leuprorelin.Methods Ovarian endometriosis patients(80 cases) after cystectomy were randomly divided into two groups to do prospective clinical observation.Patients in groups Leuprorelin and Tritorelin were iv injected with Leuprorelin 3.75 mg and Tritorelin 3.75 mg,respectively for 3—6 months and 28—30 d once.The side effects in the two groups were observed,and the follicle-stimulating hormone(FSH),luteotropic hormone(LH),and estradiol(E2) levels on days 0,7,and 21 were determined.Results Patients in Triptorelin(33 cases) and Leuprorelin(27 cases) completed the therapy.Side effects such as hot flashes,night sweats,acne,muscle pain,joint pain,headache,abnormal vaginal bleeding happened in patients in the treatment groups.Acne,headache incidence showed the significant difference between the two groups(P0.01,P0.05).Sex hormone levels in patients of the two groups showed no significant difference(P0.05);FSH,LH,and E2 levels on the day 7 after administration all had the significance(P0.01,P0.05).FSH and E2 levels in the two treatment groups both had the significance(P0.01).Conclusion The side effects and hormone level in Triptorelin and Leuprorelin are different in the treatment of EMs.Leuprorelin treatment could slowly decrease the hormone level and the side effect is low.Individualized treatment should be carried out according to the characteristics of the different preparations in clinic.