Clinical observation of intraovarian injection of autologous platelet-rich plasma in the treatment of ovarian reserve dysfunction

Objective: To investigate the effectiveness of platelet-rich plasma intraovarian injection in the treatment of patients with ovarian hypofunction.to provide a new diagnosis and treatment idea for the treatment of ovarian reserve hypofunction. Design: Intervention research. Setting: A tertiary-care hospital in Guangxi, China. Population:The patients with decreased ovarian in the Reproductive Medicine Center of Qinzhou Maternal and Child Health Hospital from January 2021 to December 2023. Methods: A total of 22 patients with decreased ovarian reserve who received autologous platelet-rich plasma intraovarian injections were collected. Among them, 11 patients received assisted reproductive technology for pregnancy. Main outcome measures:The levels of anti-Mullerian hormone, sinus follicle number, basal follicle-stimulating hormone, basal luteinizing hormone, basal estradiol, and pregnancy outcome. Results: AMH, AFC, basal FSH, basal LH, and basal E2 levels were improved in 22 patients after treatment. Ten patients obtained embryos, of which five obtained high-quality embryos. However, none of the 22 patients had a successful pregnancy. Conclusion: Intraovarian injection of autologous platelet-rich plasma can effectively improve ovarian reserve function in patients with reduced ovarian reserve function.