Chronic Intermittent Hypobaric Hypoxia Prevents contrast-Induced Acute Kidney Injury by Modulating the HIF-1α Signaling Pathway

The aim of this study was to explore the role of CIHH in preventing contrast-induced acute kidney injury (CI-AKI) in rats and its mechanism. Rats mean arterial pressure ,heart rate, blood creatinine and urea nitrogen levels were measured. The kidney tissue pathological changes, superoxide dismutase (SOD) activity, malondialdehyde (MDA)levels, HIF-1α、Bcl-2 19-kDa interacting protein3 (BNIP3)、caspase3and poly(ADP-ribose) polymerase (PARP) expression levels were testing. The results showed that CIHH pretreatment CI-AKI group mean arterial pressure、heart rate、blood creatinine and urea nitrogen levels were reduced, kidney tissue SOD activity was increased, MDA levels was reduced, HIF-1α、 BNIP3、caspase3 and PARP levels were increased than the CI-AKI group. This study indicates that CIHH pretreatment may have a protective effect on contrast-induced early kidney injury by activating the HIF-1α/BNIP3 signaling pathway to regulate mitochondrial autophagy and enhance cellular anti-apoptotic and renal antioxidant capacity, for the first time.