Do Entrapment, Injuries, Outcomes and Potential for Self-extrication Vary with Age? A Pre-specified Analysis of the UK Trauma Registry (TARN)

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Abstract Background:Motor vehicle collisions (MVCs), particularly those associated with entrapment, are a common cause of major trauma. Current extrication methods are focused on spinal movement minimisation and mitigation, but for many patients’ self-extrication may be an appropriate alternative. Older drivers and passengers are increasingly injured in MVCs and may be at an increased risk of entrapment and its deleterious effects. The aim of this study is to describe the injuries, trapped status, outcomes, and potential for self-extrication for patients following an MVC across a range of age groups. Methods:This is a retrospective study using the Trauma Audit and Research Network (TARN) database. Patients were included if they were admitted to an English hospital following an MVC from 2012 to 2019. Patients were excluded when their outcomes were not known or if they were secondary transfers. Simple descriptive analysis was used across the age groups: 16-59, 60-69, 70-79 and 80+ years. Logistic regression was performed to develop a model with known confounders, considering the odds of death by age group, and examining any interaction between age and trapped status with mortality. Results:70,027 patients met the inclusion criteria. Older patients were more likely to be trapped and to die following an MVC (p<0.0001). Head, abdominal and limb injuries were more common in the young with thoracic and spinal injuries being more common in older patients (all p<0.0001). No statistical difference was found between the age groups in relation to ability to self-extricate. After adjustment for confounders, the 80+ age group were more likely to die if they were trapped; adjusted OR trapped 30.2 (19.8 - 46), not trapped 24.2 (20.1 - 29.2). Conclusions:Patients over the age of 80 are more likely to die when trapped following an MVC. Self-extrication should be considered the primary route of egress for patients of all ages unless it is clearly impracticable or unachievable. For those patients who cannot self-extricate, a minimally invasive extrication approach should be employed to minimise entrapment time.
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Do Entrapment, Injuries, Outcomes and Potential for Self-extrication Vary with Age? 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A Pre-specified Analysis of the UK Trauma Registry (TARN) Tim Nutbeam, Anthony Kehoe, Rob Fenwick, Jason Smith, Omar Bouamra, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1076806/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 05 Mar, 2022 Read the published version in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine → Version 1 posted 8 You are reading this latest preprint version Abstract Background: Motor vehicle collisions (MVCs), particularly those associated with entrapment, are a common cause of major trauma. Current extrication methods are focused on spinal movement minimisation and mitigation, but for many patients’ self-extrication may be an appropriate alternative. Older drivers and passengers are increasingly injured in MVCs and may be at an increased risk of entrapment and its deleterious effects. The aim of this study is to describe the injuries, trapped status, outcomes, and potential for self-extrication for patients following an MVC across a range of age groups. Methods: This is a retrospective study using the Trauma Audit and Research Network (TARN) database. Patients were included if they were admitted to an English hospital following an MVC from 2012 to 2019. Patients were excluded when their outcomes were not known or if they were secondary transfers. Simple descriptive analysis was used across the age groups: 16-59, 60-69, 70-79 and 80+ years. Logistic regression was performed to develop a model with known confounders, considering the odds of death by age group, and examining any interaction between age and trapped status with mortality. Results: 70,027 patients met the inclusion criteria. Older patients were more likely to be trapped and to die following an MVC (p<0.0001). Head, abdominal and limb injuries were more common in the young with thoracic and spinal injuries being more common in older patients (all p<0.0001). No statistical difference was found between the age groups in relation to ability to self-extricate. After adjustment for confounders, the 80+ age group were more likely to die if they were trapped; adjusted OR trapped 30.2 (19.8 - 46), not trapped 24.2 (20.1 - 29.2). Conclusions: Patients over the age of 80 are more likely to die when trapped following an MVC. Self-extrication should be considered the primary route of egress for patients of all ages unless it is clearly impracticable or unachievable. For those patients who cannot self-extricate, a minimally invasive extrication approach should be employed to minimise entrapment time. Critical Care & Emergency Medicine Older patients Extrication Accidents traffic Spinal injury Emergency Medical Services Figures Figure 1 Figure 2 Background: Motor vehicle collisions (MVCs) are a frequent cause of trauma and death for patients of all ages. Following an MVC some patients will be trapped. Only around 10% of such patients are physically trapped by deformation of the vehicle, requiring dismantling of the vehicle and space creation by rescue services[ 1 ]. The overwhelming majority are trapped due to painful injuries inhibiting movement or physiological impairment rendering voluntary movement difficult. However, often it is rescuer or casualty concerns about exacerbating secondary spinal injury which prevent self or minimally assisted extrication. Being trapped through any of these mechanisms is associated with excess mortality[ 2 ]. It is not yet clear whether this can be mitigated by reducing extrication time[ 3 ]. Extrication strategies have historically focused on movement mitigation such as roof removal techniques, which inherently take longer to deliver than self-extrication. However, recent work has demonstrated the biomechanical and time advantages of self-extrication over tool-based techniques (ref to follow). Minimising entrapment time reduces avoidable delays to diagnosis and clinical interventions, whilst also reducing the detrimental effects of environmental exposure. A combination of these factors and others may lead to the excess mortality seen in trapped casualties. Average life expectancy is increasing throughout most of the world, with the most rapidly growing segment of the population being people aged over 60 years[ 4 ]. With this changing demographic, healthcare systems have witnessed a disproportionate rise in older patients suffering from major trauma, with this group now representing over 50% of the major trauma cases reported in the UK[ 4 , 5 ]. There are more older drivers (and passengers) on the roads than ever before, with older road users representing 12% of car driving license holders and 9% of road miles travelled [ 6 , 7 ]. Older patients have a higher mortality rate, with those over 70 representing a disproportionate 20% of all car driver deaths [ 8 ]. Older casualties may be at increased risk of entrapment through decreased baseline mobility, a propensity to frailty and vulnerability to certain types of injury[ 4 ]. It is unknown if older patients are more at risk from the dangerous effects of prolonged entrapment. Extrication may be delayed due to rescuer perceptions about the incidence of spinal injury in this group and their ability to self-extricate [ 9 ]. The aims of this study were to describe the rate of entrapment, the type and frequency of injuries, and outcomes in different age groups, and whether there is disproportionate mortality from entrapment in older patients. We also compared the incidence of factors likely to impede self-extrication between the groups. Methods: This is a retrospective review of the UK Trauma Audit and Research Network (TARN) database. TARN is the UK national trauma registry into which all Major Trauma Centres submit data on severely injured patients. TARN moved from voluntary to mandatory submission of data from MVCs in 2012. Eligibility criteria include trauma patients who are admitted to hospital for ≥72 hours, are admitted to a critical care unit, die in hospital, or are transferred to another hospital for specialist trauma care. Isolated closed fractures of the limbs and hip fractures in patients over 65 are excluded. TARN includes patient demographics, initial physiology, treatment interventions, detail of injuries and in some circumstances (including MVCs) their trapped status. This study describes the rate of entrapment by age group, considering the effect of being trapped on outcomes and whether this effect modifies with age. Reporting the rate and type of spinal injuries, other severe potentially time critical injuries and traumatic and physiological challenges to self-extrication by age group will inform choice of extrication strategy [ 10 , 11 ]. Patients were included if they were admitted between January 2012 and December 2019, were involved in an MVC, were admitted directly to an English hospital, and had a known outcome. Patients were excluded when their trapped status was not known. For patients who met the inclusion criteria, data fields including age, trapped status, injury severity score (ISS), abbreviated injury score (AIS) for each body region were reported. In addition we report details of spinal injury and other severe injuries that we have previously defined 2 . Adults were categorised into age groups: 16-59, 60-69, 70-79 and 80+ years. These age groups were selected as they have previously been defined by TARN [ 4 ]. The 80+ age group were considered as a whole to prevent the statistical artifact associated with small sample sizes. Simple descriptive analysis was used to define the characteristics of the groups by age category and trapped status. A two-tailed t-test was used to compare means and Mann-Whitney U test for comparing medians. The Chi square test for uniform distribution was used for categorical variables. P values of less than 0.01 were considered significant due to multiple analyses being performed. Logistic regression was used to develop a model with the following known confounders: gender, ISS, GCS, Charlson comorbidity index and entrapment status as exposure variables, considering the odds of death by age group, and examining any interaction between age and trapped status with mortality. Missing values for GCS were imputed under the assumption of a mechanism of missing at random (MAR). SPSS (IBM Corp v.23 Armonk, NY), Stata (StataCorp. 2015. Stata Statistical Software: Release 14. College Station, TX) and R (Integrated Development for R. RStudio, PBC, Boston, MA, v.1.4) software were used for the analyses. Factors were identified which the research group from their clinical and operational experience which were likely to affect the ability of a patient to successfully self-extricate. Factors identified were any one of: GCS 12 or less; Spine, Limb or Pelvis Abbreviated Injury Scale (AIS) score of 3+; or a systolic blood pressure of <90 mmHg. TARN data analyses are conducted using anonymised data which is governed by a code of practice approved by the Confidentiality Advisory Group who are appointed by the Health Research Authority. Additional individual ethical approval was not required for this analysis. Results: Between 2012 and 2019 there were 450,437 major trauma cases identified on the TARN database of whom 70,027 met the inclusion criteria (Figure 1 ). The characteristics of each group are summarized in Table 1 . The systolic blood pressure increased with age, whilst the pulse, respiratory rate, oxygen saturations and GCS demonstrating statistical though not clinical differences between the groups with no age-dependent trend. The median ISS was similar across the age groups. Thirty-day mortality increased with increasing age from 4.1% (16-59) to 16.4% (80+). Table 1 Demographics and Mortality by Age Age groups Total 16 - 59 60 - 69 70 - 79 80+ Significance (p) Total number of cases 70027 51868 7605 5733 4821 < 0.0001 Male, n (%) 51852 (74%) 40957 (79%) 5232 (68.8%) 3197 (55.8%) 2466 (51.2%) < 0.0001 ISS, median (IQR) 13 (9 - 22) 13 (9 - 24) 13 (9 - 22) 13 (9 - 24) 13 (9 - 22) < 0.0001 Systolic BP, mean (SD) 133 (28) 129 (25) 140 (30) 145 (33) 149 (34) < 0.0001 Pulse rate, mean (SD) 87 (22) 88 (22) 83 (21) 83 (22) 83 (21) < 0.0001 Respiratory rate, mean (SD) 20 (7) 20 (7) 20 (7) 20 (7) 20 (7) n/a Oxygen saturation, mean (SD) 96 (8) 96 (8) 96 (8) 95 (9) 95 (7) < 0.0001 GCS, median (IQR) 15 (15 - 15) 15 (15 - 15) 15 (15 - 15) 15 (15 - 15) 15 (15 - 15) n/a Trapped, n (%) 7754 (11.1%) 5642(10.9%) 807 (10.6%) 756 (13.2%) 549 (11.4%) < 0.0001 Mortality, n (%) 3868 (5.5%) 2125 (4.1%) 391 (5.1%) 564 (9.8%) 788 (16.4%) < 0.0001 IQR interquartile range, SD standard deviation. As shown in Table 2 , unadjusted and adjusted odds of death increased with age. Trapped patients over 80 had an increased mortality rate compared to those that were not trapped (Figure 2 ). This model performed well, with a discrimination area under the receiver operator curve (ROC, C-statistic) of 0.952 (95% CI 0.948 - 0.955). Table 2 Trapped status and mortality by age Trapped at scene Not trapped at scene Age groups 16 - 59 60 - 69 70 - 79 80 + 16 - 59 60 - 69 70 - 79 80 + Unadjusted Odds Ratio of death (95% CI) 1 1.1 (0.9 - 1.5) 1.7 (1.4 - 2.2) 4.4 (3.6 - 5.5) 1 1.3 (1.2 - 1.5) 2.7 (2.5 - 3.0) 4.6 (4.2 - 5.1) Adjusted Odds Ratio of death (95% CI) 1 3.7 (2.3 - 5.9) 8.5 (5.5 - 13.3) 30.2 (19.8 - 46) 1 2.8 (2.3 - 3.4) 8.7 (7.2 - 10.6) 24.2 (20.1 - 29.2) Adjusted for gender, ISS, GCS, Comorbidity In patients who were trapped, severe injuries occurred with similar frequency across all age categories (Table 3 ). Injuries (AIS 3+) to the head, face, abdomen and limbs were more common in the young (16-59, Table 4 ). Thoracic injuries were more frequent in those aged 60 or above. The frequency of multiple spinal fractures, dens fractures, unstable fractures and cord injuries were highest in the 70-79 age group. Table 3 Severe and spinal injuries by age for trapped casualties Age group Injury Total 16 - 59 60 - 69 70 - 79 80+ Significance (p) Pelvic Ring Blood loss>20% 71 (0.9%) 53 (0.9%) 9 (1.1%) 5 (0.7%) 4 (0.7%) 0.7578 Blood Loss>20% 275 (3.5%) 210 (3.7%) 28 (3.5%) 20 (2.6%) 17 (3.1%) 0.4503 Tension pneumothorax 118 (1.5%) 91 (1.6%) 12 (1.5%) 8 (1.1%) 7 (1.3%) 0.6535 Spine multiple fractures 1078 (13.9%) 734 (13%) 114 (14.1%) 150 (19.8%) 80 (14.6%) < 0.0001 Spine dens fracture 164 (2.1%) 87 (1.5%) 19 (2.4%) 37 (4.9%) 21 (3.8%) < 0.0001 Spine compression grade 2 and 3 141 (1.8%) 98 (1.7%) 13 (1.6%) 17 (2.2%) 13 (2.4%) 0.5485 Spine unstable fracture 717 (9.2%) 502 (8.9%) 79 (9.8%) 94 (12.4%) 42 (7.7%) 0.0077 Spinal cord injury 526 (6.8%) 376 (6.7%) 51 (6.3%) 63 (8.3%) 36 (6.6%) 0.3452 Table 4 Injury site (AIS 3+) by age for trapped casualties Age group Anatomical Site Total 16 - 59 60 - 69 70 - 79 80+ Significance (p) Head 1896 (24.5%) 1528 (27.1%) 135 (16.7%) 139 (18.4%) 94 (17.1%) < 0.0001 Face 52 (0.7%) 43 (0.8%) 3 (0.4%) 5 (0.7%) 1 (0.2%) < 0.0001 Thorax 4159 (53.6%) 2945 (52.2%) 438 (54.3%) 430 (56.9%) 346 (63%) < 0.0001 Abdomen 950 (12.3%) 770 (13.6%) 74 (9.2%) 65 (8.6%) 41 (7.5%) < 0.0001 Spine 844 (10.9%) 577 (10.2%) 96 (11.9%) 109 (14.4%) 62 (11.3%) < 0.0001 Pelvic 895 (11.5%) 686 (12.2%) 82 (10.2%) 60 (7.9%) 67 (12.2%) < 0.0001 Limb 2522 (32.5%) 2028 (35.9%) 232 (28.7%) 164 (21.7%) 98 (17.9%) < 0.0001 Statistically significant but not clinically significant differences were demonstrated across the physiological and injury-based considerations for self-extrication. The proportion of patients with injuries likely to preclude self-extrication was similar across the age groups (Table 5 ). Table 5 Physiological and injury considerations for potential for self-extrication by age Age group Parameter Total 16 - 59 60 - 69 70 - 79 80+ Significance (p) Systolic BP <90 418 (5.4%) 301 (5.3%) 48 (6.0%) 39 (5.2%) 30 (5.5%) 0.908 GCS 12 or less 1183 (15.3%) 1006 (17.8%) 68 (8.4%) 57 (7.5%) 52 (9.5%) < 0.0001 Spine AIS3+ 844 (10.9%) 577 (10.2%) 96 (11.9%) 109 (14.4%) 62 (11.3%) < 0.0001 Pelvic AIS 3+ 895 (11.5%) 686 (12.2%) 82 (10.2%) 60 (7.9%) 67 (12.2%) < 0.0001 Limb AIS 3+ 2522 (32.5%) 2028 (35.9%) 232 (28.7%) 164 (21.7%) 98 (17.9%) < 0.0001 None of the above 3208 (41.4%) 2264 (40.1%) 343 (42.5%) 357 (47.2%) 244 (44.4%) 0.079 Discussion: Patients over 80 years old are particularly vulnerable to the negative effects of entrapment following an MVC. Older patients are more likely to have chest and spinal injuries than younger patients - however, the overall rate of spinal injuries remains very low. Across the age groups, approximately 40% of patients who were trapped did not have injuries or physiological impairment likely to hinder self-extrication. Meaning of the study : This study offers fresh insights that are useful for those providing clinical care on scene, planning extrication strategies and supporting clinicians in enabling patients to self-extricate. Injuries of the head, thorax, face and limb are unlikely to benefit from a longer extrication strategy based on movement mitigation when other quicker routes such as self-extrication could be considered; these injuries may be time dependent and the extended time these patients remain in the vehicle will add to excess mortality related to bleeding and hypoxia [ 6 , 12 ]. Gentle patient handling and movement mitigation may help with prevention of clot disruption in abdominal or pelvic injury [ 13 ], but these significant injuries often require blood product resuscitation and early access to hospital-based services for identification of injury (CT scan) and treatment (interventional radiology or damage control surgery)[ 14 ]. The small increased rate of spinal injuries in older patients may be because of the decreased bone density, muscle and ligament strength and degenerative changes causing narrowing of the spinal canal experienced by the older patient [ 9 ]. Recent work has identified that self-extrication results in less movement of the cervical and lumbar spine than other extrication types in healthy volunteers (ref to follow). If these findings can be extrapolated to the injured population, self-extrication may present the best route of egress even for those with suspected spinal injuries. Patients, and particularly older patients may have occult injuries [ 15 ]. As such, predicting a patient’s ability to self-extricate is complex. We suggest that self-extrication has significant advantages over more formal alternative extrication techniques and as such should be considered as a route of egress for all patients unless it is clearly impracticable or unachievable. The advantages of self-extrication for the patient include minimal entrapment time (self-extrication is quickest) and minimal movement (ref to follow). For those patients who cannot self-extricate a minimally invasive extrication approach should be used – providing the patient with the necessary support to extricate from the vehicle with minimal cutting / space creation using the principles of gentle patient handling. Strengths and weaknesses : This is the largest analysis to date of trapped patients injured in motor vehicle collisions, which allows comparison of injury severity, injury type and outcomes for patients stratified by age. TARN data may be incomplete, with patients aged over 60 having a lower level of data completeness than younger patients [ 4 ]. This study is based upon chronological age – the effects of which are subject to considerable variation between individuals [ 16 ]. This study does not specifically report frailty – which is likely to be an important factor both in a patient’s resilience to injury and their potential to recover successfully from injury and therefore affect both injury severity and mortality [ 17 ]. We have selected pragmatic physiological and injury-based criteria which are likely to affect the ability of a patient to participate in self-extrication. These criteria have not been validated in this setting but provide useful context. This study is limited in that it does not report non-patient factors relating to the scene of a collision which will affect clinical decision making. We do not report type of vehicle, closing speed, vehicle damage or the use and/or deployment of restraint systems. Importantly we cannot distinguish between patients that are physically trapped and those that are medically trapped following their MVC. Unanswered questions and future research : Future work should focus on clearly defining patient groups that are not suitable for self-extrication. This may be through prospective data collection of extrication type and patient outcomes, expert consensus, and patient consultation. It is important to distinguish between patients who are physically trapped and those that are medically trapped, and this should be routinely collected on operational and medical data sets considering trapped patients post MVC. Conclusions: Patients over the age of 80 are more likely to die when trapped following an MVC. Older patients are more likely to have chest and spinal injuries than younger patients - however, the overall rate of spinal injuries remains low across all age groups. Older patients are no more likely to have injuries that would hinder self-extrication than younger patients. Self-extrication should be considered the primary route of egress for patients of all ages apart from where it is clearly impracticable or unachievable. For those patients who cannot self-extricate a minimally invasive extrication approach should be employed to minimise entrapment time. Declarations Ethics approval and consent to participate TARN data analyses are conducted using anonymised data which is governed by a code of practice approved by the Confidentiality Advisory Group who are appointed by the Health Research Authority. Additional individual ethical approval was not required for this analysis. Consent for publication Not applicable. Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Competing interests The authors declare that they have no competing interests Funding Publication costs were funded by a charitable grant from the Road Safety Trust. The Road Safety Trust had no role in the design, data collection, analysis or writing of this manuscript. Authors' contributions TN, TK, RF, JS, LW and WS contributed to the conception and study design, analysis and interpretation of data, drafting and revising the manuscript. OB contributed to the analysis and interpretation of the data and critically revised the manuscript. All authors read and approved the final manuscript. Acknowledgements We would like to thank TARN and the TARN research committee for their support. Authors' information (optional) Not applicable. References Fenwick R, Nutbeam T. 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Cite Share Download PDF Status: Published Journal Publication published 05 Mar, 2022 Read the published version in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine → Version 1 posted Editorial decision: Major Revision 14 Dec, 2021 Reviews received at journal 18 Nov, 2021 Reviewers invited by journal 18 Nov, 2021 Reviewer # 1 agreed at journal 17 Nov, 2021 Editor assigned by journal 15 Nov, 2021 Submission checks completed at journal 14 Nov, 2021 Editor invited by journal 14 Nov, 2021 First submitted to journal 13 Nov, 2021 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1076806","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":64381416,"identity":"f515f03b-c679-4e4a-9810-6fae41a66989","order_by":0,"name":"Tim 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(TARN)","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Omar","middleName":"","lastName":"Bouamra","suffix":""},{"id":64381421,"identity":"b9d220ec-b115-435f-97c2-5a238662ed46","order_by":5,"name":"Lee Wallis","email":"","orcid":"","institution":"UCT Faculty of Health Sciences: University of Cape Town Faculty of Health Sciences","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lee","middleName":"","lastName":"Wallis","suffix":""},{"id":64381422,"identity":"ebdb5ba0-3bfc-45f6-bac9-2711e33d3ff5","order_by":6,"name":"Willem Stassen","email":"","orcid":"","institution":"UCT Faculty of Health Sciences: University of Cape Town Faculty of Health Sciences","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Willem","middleName":"","lastName":"Stassen","suffix":""}],"badges":[],"createdAt":"2021-11-13 10:35:07","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1076806/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1076806/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s13049-021-00989-w","type":"published","date":"2022-03-05T19:48:09+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":15774153,"identity":"edf8691f-979b-4aaa-942c-a6fe6a281a97","added_by":"auto","created_at":"2021-11-22 13:57:47","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":56228,"visible":true,"origin":"","legend":"STROBE Diagram ","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-1076806/v1/abd873629824828b33c8ec7b.jpg"},{"id":15774154,"identity":"685d30e9-b25a-4e7b-9fd2-731baf42ec5b","added_by":"auto","created_at":"2021-11-22 13:57:47","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":7726,"visible":true,"origin":"","legend":"Age and adjusted odds of death","description":"","filename":"OnlineFig2.png","url":"https://assets-eu.researchsquare.com/files/rs-1076806/v1/7fb1fc9c557ef9d207db3ec8.png"},{"id":18887578,"identity":"ed9ceb9d-b65c-4d44-8bc8-a5cb8818cc14","added_by":"auto","created_at":"2022-03-05 19:48:16","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":378141,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1076806/v1/fb68ced6-832b-4cab-b493-11b51939eaf4.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eDo Entrapment, Injuries, Outcomes and Potential for Self-extrication Vary with Age? A Pre-specified Analysis of the UK Trauma Registry (TARN)\u003c/p\u003e","fulltext":[{"header":"Background:","content":"\u003cp\u003eMotor vehicle collisions (MVCs) are a frequent cause of trauma and death for patients of all ages. Following an MVC some patients will be trapped. Only around 10% of such patients are physically trapped by deformation of the vehicle, requiring dismantling of the vehicle and space creation by rescue services[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. The overwhelming majority are trapped due to painful injuries inhibiting movement or physiological impairment rendering voluntary movement difficult. However, often it is rescuer or casualty concerns about exacerbating secondary spinal injury which prevent self or minimally assisted extrication.\u003c/p\u003e \u003cp\u003eBeing trapped through any of these mechanisms is associated with excess mortality[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. It is not yet clear whether this can be mitigated by reducing extrication time[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. Extrication strategies have historically focused on movement mitigation such as roof removal techniques, which inherently take longer to deliver than self-extrication. However, recent work has demonstrated the biomechanical and time advantages of self-extrication over tool-based techniques (ref to follow). Minimising entrapment time reduces avoidable delays to diagnosis and clinical interventions, whilst also reducing the detrimental effects of environmental exposure. A combination of these factors and others may lead to the excess mortality seen in trapped casualties.\u003c/p\u003e \u003cp\u003eAverage life expectancy is increasing throughout most of the world, with the most rapidly growing segment of the population being people aged over 60 years[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. With this changing demographic, healthcare systems have witnessed a disproportionate rise in older patients suffering from major trauma, with this group now representing over 50% of the major trauma cases reported in the UK[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. There are more older drivers (and passengers) on the roads than ever before, with older road users representing 12% of car driving license holders and 9% of road miles travelled [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Older patients have a higher mortality rate, with those over 70 representing a disproportionate 20% of all car driver deaths [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eOlder casualties may be at increased risk of entrapment through decreased baseline mobility, a propensity to frailty and vulnerability to certain types of injury[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. It is unknown if older patients are more at risk from the dangerous effects of prolonged entrapment. Extrication may be delayed due to rescuer perceptions about the incidence of spinal injury in this group and their ability to self-extricate [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe aims of this study were to describe the rate of entrapment, the type and frequency of injuries, and outcomes in different age groups, and whether there is disproportionate mortality from entrapment in older patients. We also compared the incidence of factors likely to impede self-extrication between the groups.\u003c/p\u003e"},{"header":"Methods:","content":"\u003cp\u003eThis is a retrospective review of the UK Trauma Audit and Research Network (TARN) database. TARN is the UK national trauma registry into which all Major Trauma Centres submit data on severely injured patients. TARN moved from voluntary to mandatory submission of data from MVCs in 2012. Eligibility criteria include trauma patients who are admitted to hospital for \u0026ge;72 hours, are admitted to a critical care unit, die in hospital, or are transferred to another hospital for specialist trauma care. Isolated closed fractures of the limbs and hip fractures in patients over 65 are excluded. TARN includes patient demographics, initial physiology, treatment interventions, detail of injuries and in some circumstances (including MVCs) their trapped status.\u003c/p\u003e \u003cp\u003eThis study describes the rate of entrapment by age group, considering the effect of being trapped on outcomes and whether this effect modifies with age. Reporting the rate and type of spinal injuries, other severe potentially time critical injuries and traumatic and physiological challenges to self-extrication by age group will inform choice of extrication strategy [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e].\u003c/p\u003e \u003cp\u003ePatients were included if they were admitted between January 2012 and December 2019, were involved in an MVC, were admitted directly to an English hospital, and had a known outcome. Patients were excluded when their trapped status was not known. For patients who met the inclusion criteria, data fields including age, trapped status, injury severity score (ISS), abbreviated injury score (AIS) for each body region were reported. In addition we report details of spinal injury and other severe injuries that we have previously defined \u003csup\u003e2\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eAdults were categorised into age groups: 16-59, 60-69, 70-79 and 80+ years. These age groups were selected as they have previously been defined by TARN [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. The 80+ age group were considered as a whole to prevent the statistical artifact associated with small sample sizes. Simple descriptive analysis was used to define the characteristics of the groups by age category and trapped status. A two-tailed t-test was used to compare means and Mann-Whitney U test for comparing medians. The Chi square test for uniform distribution was used for categorical variables. \u003cem\u003eP\u003c/em\u003e values of less than 0.01 were considered significant due to multiple analyses being performed. Logistic regression was used to develop a model with the following known confounders: gender, ISS, GCS, Charlson comorbidity index and entrapment status as exposure variables, considering the odds of death by age group, and examining any interaction between age and trapped status with mortality. Missing values for GCS were imputed under the assumption of a mechanism of missing at random (MAR). SPSS (IBM Corp v.23 Armonk, NY), Stata (StataCorp. 2015. Stata Statistical Software: Release 14. College Station, TX) and R (Integrated Development for R. RStudio, PBC, Boston, MA, v.1.4) software were used for the analyses.\u003c/p\u003e \u003cp\u003eFactors were identified which the research group from their clinical and operational experience which were likely to affect the ability of a patient to successfully self-extricate. Factors identified were any one of: GCS 12 or less; Spine, Limb or Pelvis Abbreviated Injury Scale (AIS) score of 3+; or a systolic blood pressure of \u0026lt;90 mmHg.\u003c/p\u003e \u003cp\u003eTARN data analyses are conducted using anonymised data which is governed by a code of practice approved by the Confidentiality Advisory Group who are appointed by the Health Research Authority. Additional individual ethical approval was not required for this analysis.\u003c/p\u003e"},{"header":"Results:","content":"\u003cp\u003eBetween 2012 and 2019 there were 450,437 major trauma cases identified on the TARN database of whom 70,027 met the inclusion criteria (Figure \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003eThe characteristics of each group are summarized in Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e. The systolic blood pressure increased with age, whilst the pulse, respiratory rate, oxygen saturations and GCS demonstrating statistical though not clinical differences between the groups with no age-dependent trend. The median ISS was similar across the age groups. Thirty-day mortality increased with increasing age from 4.1% (16-59) to 16.4% (80+).\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\u0026nbsp;\u003ctable border=\"1\" id=\"Tab1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eDemographics and Mortality by Age\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003ccolgroup cols=\"7\"\u003e\u003c/colgroup\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eAge groups\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eTotal\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e16 - 59\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e60 - 69\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e70 - 79\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e80+\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eSignificance (p)\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eTotal number of cases\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e70027\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e51868\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7605\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5733\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4821\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMale, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e51852 (74%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e40957 (79%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5232 (68.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3197 (55.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2466 (51.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eISS, median (IQR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (9 - 22)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (9 - 24)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (9 - 22)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (9 - 24)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (9 - 22)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSystolic BP, mean (SD)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e133 (28)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e129 (25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e140 (30)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e145 (33)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e149 (34)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePulse rate, mean (SD)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e87 (22)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e88 (22)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e83 (21)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e83 (22)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e83 (21)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eRespiratory rate, mean (SD)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20 (7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20 (7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20 (7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20 (7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20 (7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en/a\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOxygen saturation, mean (SD)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e96 (8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e96 (8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e96 (8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e95 (9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e95 (7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eGCS, median (IQR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15 (15 - 15)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15 (15 - 15)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15 (15 - 15)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15 (15 - 15)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15 (15 - 15)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en/a\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eTrapped, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7754 (11.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5642(10.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e807 (10.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e756 (13.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e549 (11.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMortality, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3868 (5.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2125 (4.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e391 (5.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e564 (9.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e788 (16.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\"\u003eIQR interquartile range, SD standard deviation.\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eAs shown in Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e, unadjusted and adjusted odds of death increased with age. Trapped patients over 80 had an increased mortality rate compared to those that were not trapped (Figure \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e). This model performed well, with a discrimination area under the receiver operator curve (ROC, C-statistic) of 0.952 (95% CI 0.948 - 0.955).\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\u0026nbsp;\u003ctable border=\"1\" id=\"Tab2\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eTrapped status and mortality by age\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003ccolgroup cols=\"9\"\u003e\u003c/colgroup\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eTrapped at scene\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eNot trapped at scene\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eAge groups\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16 - 59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e60 - 69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e70 - 79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e80 +\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16 - 59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e60 - 69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e70 - 79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e80 +\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eUnadjusted Odds Ratio of death (95% CI)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.1 (0.9 - 1.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.7 (1.4 - 2.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4.4 (3.6 - 5.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.3 (1.2 - 1.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e2.7 (2.5 - 3.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4.6 (4.2 - 5.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eAdjusted Odds Ratio of death (95% CI)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e3.7 (2.3 - 5.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e8.5 (5.5 - 13.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.2 (19.8 - 46)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e2.8 (2.3 - 3.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e8.7 (7.2 - 10.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24.2 (20.1 - 29.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cdiv class=\"Section2\" id=\"Sec7\"\u003e\n \u003ch2\u003eAdjusted for gender, ISS, GCS, Comorbidity\u003c/h2\u003e\n \u003cp\u003eIn patients who were trapped, severe injuries occurred with similar frequency across all age categories (Table \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e). Injuries (AIS 3+) to the head, face, abdomen and limbs were more common in the young (16-59, Table \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e). Thoracic injuries were more frequent in those aged 60 or above.\u003c/p\u003e\n \u003cp\u003eThe frequency of multiple spinal fractures, dens fractures, unstable fractures and cord injuries were highest in the 70-79 age group.\u0026nbsp;\u003c/p\u003e\u0026nbsp;\u003ctable border=\"1\" id=\"Tab3\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eSevere and spinal injuries by age for trapped casualties\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eAge group\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eInjury\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eTotal\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e16 - 59\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e60 - 69\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e70 - 79\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e80+\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eSignificance (p)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePelvic Ring Blood loss\u0026gt;20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e71 (0.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e53 (0.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9 (1.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.7578\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eBlood Loss\u0026gt;20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e275 (3.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e210 (3.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e28 (3.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20 (2.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17 (3.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.4503\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eTension pneumothorax\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e118 (1.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e91 (1.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12 (1.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8 (1.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7 (1.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.6535\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSpine multiple fractures\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1078 (13.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e734 (13%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e114 (14.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e150 (19.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e80 (14.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSpine dens fracture\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e164 (2.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e87 (1.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19 (2.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e37 (4.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21 (3.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSpine compression grade 2 and 3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e141 (1.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e98 (1.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (1.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17 (2.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (2.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.5485\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSpine unstable fracture\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e717 (9.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e502 (8.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e79 (9.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e94 (12.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e42 (7.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.0077\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSpinal cord injury\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e526 (6.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e376 (6.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e51 (6.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e63 (8.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e36 (6.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.3452\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003cp\u003e\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\u0026nbsp;\u003ctable border=\"1\" id=\"Tab4\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eInjury site (AIS 3+) by age for trapped casualties\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eAge group\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eAnatomical Site\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eTotal\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e16 - 59\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e60 - 69\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e70 - 79\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e80+\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eSignificance (p)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHead\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1896 (24.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1528 (27.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e135 (16.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e139 (18.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e94 (17.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eFace\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e52 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e43 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eThorax\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4159 (53.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2945 (52.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e438 (54.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e430 (56.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e346 (63%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eAbdomen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e950 (12.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e770 (13.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e74 (9.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e65 (8.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e41 (7.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSpine\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e844 (10.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e577 (10.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e96 (11.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e109 (14.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e62 (11.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePelvic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e895 (11.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e686 (12.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e82 (10.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e60 (7.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e67 (12.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eLimb\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2522 (32.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2028 (35.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e232 (28.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e164 (21.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e98 (17.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003cp\u003e\u003c/p\u003e\n \u003cp\u003eStatistically significant but not clinically significant differences were demonstrated across the physiological and injury-based considerations for self-extrication. The proportion of patients with injuries likely to preclude self-extrication was similar across the age groups (Table \u003cspan class=\"InternalRef\"\u003e5\u003c/span\u003e).\u003c/p\u003e\u0026nbsp;\u003ctable border=\"1\" id=\"Tab5\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 5\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003ePhysiological and injury considerations for potential for self-extrication by age\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eAge group\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eParameter\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eTotal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16 - 59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e60 - 69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e70 - 79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e80+\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSignificance (p)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSystolic BP \u0026lt;90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e418 (5.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e301 (5.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e48 (6.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e39 (5.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30 (5.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.908\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eGCS 12 or less\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1183 (15.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1006 (17.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e68 (8.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e57 (7.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e52 (9.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSpine AIS3+\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e844 (10.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e577 (10.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e96 (11.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e109 (14.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e62 (11.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePelvic AIS 3+\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e895 (11.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e686 (12.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e82 (10.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e60 (7.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e67 (12.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eLimb AIS 3+\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2522 (32.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2028 (35.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e232 (28.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e164 (21.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e98 (17.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt; 0.0001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNone of the above\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3208 (41.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2264 (40.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e343 (42.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e357 (47.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e244\u003c/p\u003e\n \u003cp\u003e(44.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.079\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003cp\u003e\u003c/p\u003e\n \u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003c/div\u003e"},{"header":"Discussion:","content":"\u003cp\u003ePatients over 80 years old are particularly vulnerable to the negative effects of entrapment following an MVC. Older patients are more likely to have chest and spinal injuries than younger patients - however, the overall rate of spinal injuries remains very low. Across the age groups, approximately 40% of patients who were trapped did not have injuries or physiological impairment likely to hinder self-extrication.\u003c/p\u003e \u003cp\u003e \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003eMeaning of the study\u003c/span\u003e: This study offers fresh insights that are useful for those providing clinical care on scene, planning extrication strategies and supporting clinicians in enabling patients to self-extricate. Injuries of the head, thorax, face and limb are unlikely to benefit from a longer extrication strategy based on movement mitigation when other quicker routes such as self-extrication could be considered; these injuries may be time dependent and the extended time these patients remain in the vehicle will add to excess mortality related to bleeding and hypoxia [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. Gentle patient handling and movement mitigation may help with prevention of clot disruption in abdominal or pelvic injury [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e], but these significant injuries often require blood product resuscitation and early access to hospital-based services for identification of injury (CT scan) and treatment (interventional radiology or damage control surgery)[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe small increased rate of spinal injuries in older patients may be because of the decreased bone density, muscle and ligament strength and degenerative changes causing narrowing of the spinal canal experienced by the older patient [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. Recent work has identified that self-extrication results in less movement of the cervical and lumbar spine than other extrication types in healthy volunteers (ref to follow). If these findings can be extrapolated to the injured population, self-extrication may present the best route of egress even for those with suspected spinal injuries.\u003c/p\u003e \u003cp\u003ePatients, and particularly older patients may have occult injuries [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. As such, predicting a patient\u0026rsquo;s ability to self-extricate is complex. We suggest that self-extrication has significant advantages over more formal alternative extrication techniques and as such should be considered as a route of egress for all patients unless it is clearly impracticable or unachievable. The advantages of self-extrication for the patient include minimal entrapment time (self-extrication is quickest) and minimal movement (ref to follow). For those patients who cannot self-extricate a minimally invasive extrication approach should be used \u0026ndash; providing the patient with the necessary support to extricate from the vehicle with minimal cutting / space creation using the principles of gentle patient handling.\u003c/p\u003e \u003cp\u003e \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003eStrengths and weaknesses\u003c/span\u003e: This is the largest analysis to date of trapped patients injured in motor vehicle collisions, which allows comparison of injury severity, injury type and outcomes for patients stratified by age.\u003c/p\u003e \u003cp\u003eTARN data may be incomplete, with patients aged over 60 having a lower level of data completeness than younger patients [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. This study is based upon chronological age \u0026ndash; the effects of which are subject to considerable variation between individuals [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. This study does not specifically report frailty \u0026ndash; which is likely to be an important factor both in a patient\u0026rsquo;s resilience to injury and their potential to recover successfully from injury and therefore affect both injury severity and mortality [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eWe have selected pragmatic physiological and injury-based criteria which are likely to affect the ability of a patient to participate in self-extrication. These criteria have not been validated in this setting but provide useful context.\u003c/p\u003e \u003cp\u003eThis study is limited in that it does not report non-patient factors relating to the scene of a collision which will affect clinical decision making. We do not report type of vehicle, closing speed, vehicle damage or the use and/or deployment of restraint systems. Importantly we cannot distinguish between patients that are physically trapped and those that are medically trapped following their MVC.\u003c/p\u003e \u003cp\u003e \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003eUnanswered questions and future research\u003c/span\u003e: Future work should focus on clearly defining patient groups that are not suitable for self-extrication. This may be through prospective data collection of extrication type and patient outcomes, expert consensus, and patient consultation. It is important to distinguish between patients who are physically trapped and those that are medically trapped, and this should be routinely collected on operational and medical data sets considering trapped patients post MVC.\u003c/p\u003e"},{"header":"Conclusions:","content":"\u003cp\u003ePatients over the age of 80 are more likely to die when trapped following an MVC. Older patients are more likely to have chest and spinal injuries than younger patients - however, the overall rate of spinal injuries remains low across all age groups. Older patients are no more likely to have injuries that would hinder self-extrication than younger patients.\u003c/p\u003e \u003cp\u003eSelf-extrication should be considered the primary route of egress for patients of all ages apart from where it is clearly impracticable or unachievable. For those patients who cannot self-extricate a minimally invasive extrication approach should be employed to minimise entrapment time.\u003c/p\u003e"},{"header":"Declarations","content":"\u003ch2\u003eEthics approval and consent to participate\u003c/h2\u003e\n\u003cp\u003eTARN data analyses are conducted using anonymised data which is governed by a code of practice approved by the Confidentiality Advisory Group who are appointed by the Health Research Authority. Additional individual ethical approval was not required for this analysis.\u003c/p\u003e\n\u003ch2\u003eConsent for publication\u003c/h2\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003ch2\u003eAvailability of data and materials\u003c/h2\u003e\n\u003cp\u003eThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003ch2\u003eCompeting interests\u003c/h2\u003e\n\u003cp\u003eThe authors declare that they have no competing interests\u003c/p\u003e\n\u003ch2\u003eFunding\u003c/h2\u003e\n\u003cp\u003ePublication costs were funded by a charitable grant from the Road Safety Trust. The Road Safety Trust had no role in the design, data collection, analysis or writing of this manuscript.\u003c/p\u003e\n\u003ch2\u003eAuthors\u0026apos; contributions\u003c/h2\u003e\n\u003cp\u003eTN, TK, RF, JS, LW and WS contributed to the conception and study design, analysis and interpretation of data, drafting and revising the manuscript. OB contributed to the analysis and interpretation of the data and critically revised the manuscript. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003ch2\u003eAcknowledgements\u003c/h2\u003e\n\u003cp\u003eWe would like to thank TARN and the TARN research committee for their support.\u0026nbsp;\u003c/p\u003e\n\u003ch2\u003eAuthors\u0026apos; information (optional)\u003c/h2\u003e\n\u003cp\u003eNot applicable. \u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eFenwick R, Nutbeam T. Medical vs. true physical traffic collision entrapment. J Paramedic Pract. 2018;10:158\u0026ndash;62.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNutbeam T, Fenwick R, Smith J, Bouamra O, Wallis L, Stassen W. A comparison of the demographics, injury patterns and outcome data for patients injured in motor vehicle collisions who are trapped compared to those patients who are not trapped. Scand J Trauma Resusc Emerg Medicine. 2021;29:17.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNutbeam T, Fenwick R, Hobson C, Holland V, Palmer M. Extrication time prediction tool. Emerg Med J. 2015;32:401.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTARN. Major Trauma in Older People. 2017; Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.tarn.ac.uk/content/downloads/3793/Major%20Trauma%20in%20Older%20People%202017.pdf\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKehoe A, Smith JE, Edwards A, Yates D, Lecky F. The changing face of major trauma in the UK. Emerg Medicine J Emj. 2015;32:911\u0026ndash;5.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eDeynse HV, Belleghem GV, Hubloue I, Lauwaert D, Moens M, Pien K, et al. The Incremental Hospitalization Cost of Significant Transport-Related Traumatic Brain Injury. J Head Trauma Rehab. 2020;35:E144\u0026ndash;55.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAbou-Raya S, ElMeguid LA. Road traffic accidents and the elderly. Geriatr Gerontol Int. 2009;9:290\u0026ndash;7.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eA P. Supporting safe driving into old age: A national older driver strategy. 2016;\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eIkpeze TC, Mesfin A. Spinal Cord Injury in the Geriatric Population: Risk Factors, Treatment Options, and Long-Term Management. Geriatric Orthop Surg Rehabilitation. 2017;8:115\u0026ndash;8.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eDunbar I. Vehicle Extrication \u0026ndash; The Next Generation. LUKAS; 2021.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNFCC. National Operational Guidance [Internet]. National Operational Guidance. 2021 [cited 2021 Oct 21]. Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.ukfrs.com/guidance/\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAzami-Aghdash S, Aghaei MH, Sadeghi-Bazarghani H. Epidemiology of Road Traffic Injuries among Elderly People; A Systematic Review and Meta-Analysis. Bulletin Emerg Trauma. 2018;6:279\u0026ndash;91.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eScott I, Porter K, Laird C, Greaves I, Bloch M. The prehospital management of pelvic fractures: initial consensus statement. Emerg Med J. 2013;30:1070.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMidwinter MJ, Woolley T. Resuscitation and coagulation in the severely injured trauma patient. Philosophical Transactions Royal Soc B Biological Sci. 2011;366:192\u0026ndash;203.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHatton GE, McNutt MK, Cotton BA, Hudson JA, Wade CE, Kao LS. Age-Dependent Association of Occult Hypoperfusion and Outcomes in Trauma. J Am Coll Surgeons. 2020;230:417\u0026ndash;25.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBrayne C, Dufouil C, Ahmed A, Dening TR, Chi L-Y, McGee M, et al. Very old drivers: findings from a population cohort of people aged 84 and over. Int J Epidemiol. 2000;29:704\u0026ndash;7.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBond EG, Durbin LL, Cisewski JA, Qian M, Guralnik JM, Kasper JD, et al. Association between baseline frailty and driving status over time: a secondary analysis of The National Health and Aging Trends Study. Inj Epidemiology. 2017;4:9.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scandinavian-journal-of-trauma-resuscitation-and-emergency-medicine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"stre","sideBox":"Learn more about [Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine](http://sjtrem.biomedcentral.com)","snPcode":"13049","submissionUrl":"https://submission.nature.com/new-submission/13049/3","title":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","twitterHandle":"@SJTREM","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Older patients, Extrication, Accidents, traffic, Spinal injury, Emergency Medical Services","lastPublishedDoi":"10.21203/rs.3.rs-1076806/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1076806/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eMotor vehicle collisions (MVCs), particularly those associated with entrapment, are a common cause of major trauma.\u0026nbsp;Current extrication methods are focused on spinal movement minimisation and mitigation, but for many patients’ self-extrication may be an appropriate alternative. Older drivers and passengers are increasingly injured in MVCs and may be at an increased risk of entrapment and its deleterious effects. The aim of this study is to describe the injuries, trapped status, outcomes, and potential for self-extrication for patients following an MVC across a range of age groups.\u0026nbsp;\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eThis is a retrospective study using the Trauma Audit and Research Network (TARN) database. Patients were included if they were admitted to an English hospital following an MVC from 2012 to 2019. Patients were excluded when their outcomes were not known or if they were secondary transfers. Simple descriptive analysis was used across the age groups: 16-59, 60-69, 70-79 and 80+ years. Logistic regression was performed to develop a model with known confounders, considering the odds of death by age group, and examining any interaction between age and trapped status with mortality. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e\u003c/p\u003e\u003cp\u003e70,027 patients met the inclusion criteria. Older patients were more likely to be trapped and to die following an MVC (p\u0026lt;0.0001). Head, abdominal and limb injuries were more common in the young with thoracic and spinal injuries being more common in older patients (all p\u0026lt;0.0001). No statistical difference was found between the age groups in relation to ability to self-extricate. After adjustment for confounders, the 80+ age group were more likely to die if they were trapped; adjusted OR trapped 30.2 (19.8 - 46), not trapped 24.2 (20.1 - 29.2).\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions:\u003c/strong\u003e\u003c/p\u003e\u003cp\u003ePatients over the age of 80 are more likely to die when trapped following an MVC. Self-extrication should be considered the primary route of egress for patients of all ages unless it is clearly impracticable or unachievable. For those patients who cannot self-extricate, a minimally invasive extrication approach should be employed to minimise entrapment time.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Do Entrapment, Injuries, Outcomes and Potential for Self-extrication Vary with Age? A Pre-specified Analysis of the UK Trauma Registry (TARN)","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-11-22 13:57:45","doi":"10.21203/rs.3.rs-1076806/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major Revision","date":"2021-12-14T13:41:33+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-11-18T14:54:29+00:00","index":0,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2021-11-18T14:39:27+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2021-11-18T00:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2021-11-16T04:19:55+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2021-11-14T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2021-11-14T23:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","date":"2021-11-13T05:34:51+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scandinavian-journal-of-trauma-resuscitation-and-emergency-medicine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"stre","sideBox":"Learn more about [Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine](http://sjtrem.biomedcentral.com)","snPcode":"13049","submissionUrl":"https://submission.nature.com/new-submission/13049/3","title":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","twitterHandle":"@SJTREM","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"42f08b8d-4ff4-4a3f-86ab-fe651e5897d8","owner":[],"postedDate":"November 22nd, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":8656194,"name":"Critical Care \u0026 Emergency Medicine"}],"tags":[],"updatedAt":"2022-03-05T19:48:09+00:00","versionOfRecord":{"articleIdentity":"rs-1076806","link":"https://doi.org/10.1186/s13049-021-00989-w","journal":{"identity":"scandinavian-journal-of-trauma-resuscitation-and-emergency-medicine","isVorOnly":false,"title":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine"},"publishedOn":"2022-03-05 19:48:09","publishedOnDateReadable":"March 5th, 2022"},"versionCreatedAt":"2021-11-22 13:57:45","video":"","vorDoi":"10.1186/s13049-021-00989-w","vorDoiUrl":"https://doi.org/10.1186/s13049-021-00989-w","workflowStages":[]},"version":"v1","identity":"rs-1076806","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1076806","identity":"rs-1076806","version":["v1"]},"buildId":"-HB7Z8yhvgn0wM9Nzuekk","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}

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