Differences in the clinical characteristics and outcomes of COVID-19 patients in the epicenter and peripheral areas of the pandemic from China: a retrospective, large-sample, comparative analysis

Differences in the clinical characteristics and outcomes of COVID-19 patients in the epicenter and peripheral areas of the pandemic from China: a retrospective, large-sample, comparative analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Differences in the clinical characteristics and outcomes of COVID-19 patients in the epicenter and peripheral areas of the pandemic from China: a retrospective, large-sample, comparative analysis Gang Wang, Feng Ming Luo, Dan Liu, Jia Sheng Liu, Ye Wang, Hong Chen, and 22 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-52333/v3 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 24 Feb, 2021 Read the published version in BMC Infectious Diseases → Version 3 posted 2 You are reading this latest preprint version Show more versions Abstract Background : There is limited information on the difference in epidemiology, clinical characteristics and outcomes of the initial outbreak of the coronavirus disease (COVID-19) in Wuhan (the epicenter) and Sichuan (the peripheral area) in the early phase of the COVID-19 pandemic. This study was conducted to investigate the differences in the epidemiological and clinical characteristics of patients with COVID-19 between the epicenter and peripheral areas of pandemic and thereby generate information that would be potentially helpful in formulating clinical practice recommendations to tackle the COVID-19 pandemic. Methods : The Sichuan & Wuhan Collaboration Research Group for COVID-19 established two retrospective cohorts that separately reflect the epicenter and peripheral area during the early pandemic. The epidemiology, clinical characteristics and outcomes of patients in the two groups were compared. Multivariate regression analyses were used to estimate the adjusted odds ratios (aOR) with regard to the outcomes. Results : The Wuhan (epicenter) cohort included 710 randomly selected patients, and the peripheral (Sichuan) cohort included 474 consecutive patients. A higher proportion of patients from the periphery had upper airway symptoms, whereas a lower proportion of patients in the epicenter had lower airway symptoms and comorbidities. Patients in the epicenter had a higher risk of death (aOR=7.64), intensive care unit (ICU) admission (aOR=1.66), delayed time from illness onset to hospital and ICU admission (aOR=6.29 and aOR=8.03, respectively), and prolonged duration of viral shedding (aOR=1.64). Conclusions : The worse outcomes in the epicenter could be explained by the prolonged time from illness onset to hospital and ICU admission. This could potentially have been associated with elevated systemic inflammation secondary to organ dysfunction and prolonged duration of virus shedding independent of age and comorbidities. Thus, early supportive care could achieve better clinical outcomes. Infectious Diseases COVID-19 case fatality epicenter peripheral area pandemic comparative analysis Figures Figure 1 Figure 2 Figure 3 Background In December 2019, an outbreak of pneumonia of unknown cause was identified in Wuhan, the capital of Hubei province in China. A novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which had not been detected previously in humans, was identified subsequently by Chinese scientists as the cause[1]. The disease was named the coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO). The clinical spectrum of COVID-19 appears to be wide, and ranges from self-limited mild upper respiratory tract illness to severe pneumonia causing hospitalization or death. The clinical characteristics of some COVID-19 case series in Wuhan, the epicenter of the pandemic, have been previously reported in detail. The reports indicated that 26% to 33% of patients required intensive care and 4% to 15% died[2-4]. After the outbreak of COVID-19 in Wuhan, the government of the Sichuan province implemented strict measures to combat COVID-19. The Health Commission of Sichuan Province (HCSP) focused on traditional public health outbreak response tactics, including isolation, quarantine, social distancing, and community containment, as recommended by the National Health Commission of China. All medical resources were allocated by the HCSP to ensure efficient use. An expert panel drawn from multidisciplinary teams was established and comprised 125 physicians who were led by Dr. Wei Min Li and Dr. Zong An Liang (the corresponding authors of this study) since January 15, 2020. This expert panel soon released emergency prevention and control guidelines for COVID-19 in the medical institutions of the Sichuan province[5]. Furthermore, we funded two additional important expert panels with psychological counseling[6] and traditional Chinese medicine as complementary and alternative treatment options[7, 8]. Physicians caring for severely or critically ill patients could receive daily internet consultations with members of the expert panel. There were 208 designated hospitals across Sichuan Province that were accessible for SARS-CoV-2-suspected or -confirmed individuals. This arrangement resulted in improved outcomes in Sichuan province, one of the peripheral areas of the pandemic. In other peripheral areas, 2% to 10.1% of patients needing intensive care, and an approximately 1.0% mortality rate were reported in recently published studies[9-11]. The factors underlying the significantly different clinical outcomes between the epicenter and peripheral areas affected by the pandemic remains largely unexplored. Recently, Liang et al .[12] observed the clinical characteristics and outcomes of hospitalized patients with COVID-19who were treated in Hubei (epicenter) or outside Hubei (non-epicenter). However, as theirs is a multicenter study, the possibility of selection bias for the included patients cannot be ruled out. Furthermore, hospitalized patients in Hubei but not in Wuhan, would not be well representative of the first-generation COVID-19 cases. Considering the rapidly increasing number of cases with SARS-CoV-2 infection worldwide, the existing research into the differences between the epicenter and peripheral areas of the pandemic in the clinical characteristics and outcomes of COVID-19 patients was insufficient. This study could provide information that would be potentially helpful in formulating clinical practice recommendations to tackle the COVID-19 pandemic worldwide. Methods Study design and subjects This was a retrospective study based on two cohorts evaluated by the Sichuan and Wuhan Collaboration Research Group for COVID-19, China. The Wuhan cohort, drawn from the epicenter area of the pandemic, was formed using a computer-generated simple random sampling method that was applied to enroll subjects from two designated hospitals, namely the Wuhan Red Cross Hospital and Renmin Hospital of Wuhan University, Wuhan, China. The Sichuan cohort, as the group of patients from the peripheral area of the pandemic, consisted of SARS-CoV-2-confirmed patients who were consecutively recruited from 41 designated hospitals until March 12, 2020. Based on the exposure history, we further divided the Sichuan cohort into two sub-cohorts, with or without Wuhan exposure history. All patients enrolled in this study were diagnosed with COVID-19 according to the interim guidance issued by the National Health Commission of China and the WHO[13]. SARS-CoV-2 infection was confirmed by a positive result on a real-time reverse-transcriptase-polymerase-chain-reaction of nasopharyngeal, pharyngeal, throat-swab or sputum specimens. Some of these patients were included in studies reported by Wei et al .[14], Xiong et al. [15] and Xiong et al .[16]; however, their study purposes are significantly different from those of this study. Data collection The medical records of patients with COVID-19 were reviewed by members of the trained research team. Epidemiological, demographic, clinical, laboratory, radiological, treatment and outcome data were collected by using standardized data collection forms (modified case record form for the clinical characterization of severe acute respiratory infection that was shared by the International Severe Acute Respiratory and Emerging Infection Consortium [ISARIC]) from the electronic medical records. The cutoff date was Mar 12, 2020. We collected details of the exposure history, clinical symptoms and signs, and laboratory findings on admission. Laboratory examinations were performed according to the clinical care needs of the patients. Data on radiological abnormalities were extracted from the selected documentation. Patients were excluded if their medical records were not available. A team of trained researchers abstracted the data and entered the structured spreadsheet. All data were cross-checked. Study outcomes The primary outcomes included death or mechanical ventilation whether or not it involved intensive care unit (ICU) admission. Mechanical ventilation was performed in the ward if ICU admission was not possible due to the overwhelming numbers of COVID-19 patients. The secondary outcomes were the rate of ICU admission, time from illness onset to ICU admission and discharge, length of hospital stay, and duration of viral shedding after COVID-19 onset. Duration of viral shedding was defined to ended when two consecutive negative results with qPCR detection were obtained at time intervals greater than 24 hours. The criteria for discharge were absence of fever for at least 3 days, substantial improvement in both lungs on chest computed tomography (CT), clinical remission of respiratory symptoms and comorbidities, and cessation of SARS-Cov-2. Statistical analysis Continuous variables were compared using the Student's t test or the Mann-Whitney U test; categorical variables were compared by the chi-square test or Fisher’s exact test as appropriate. Logistic or linear regression was performed to identify clinical variables that were associated with outcomes. The detailed statistical analysis is described in the supplementary data. Results Epidemiological and clinical characteristics at hospitalization As of March 12, 2020, a total of 1979 cases from the two hospitals in Wuhan were identified. The Wuhan cohort included 35.9% (n=710) of all patients from Wuhan, selected using a computer-generated simple random sampling method, formed the Wuhan cohort. In the Wuhan cohort, illness onset in the first case was noted on December 24, 2019, and the first hospitalization occurred on January 5, 2020 (Figure 1A). There were 538 patients with COVID-19 who were consecutively admitted to 41 designated hospitals in Sichuan Province. The Sichuan cohort comprised 474 patients (Figure 1B), when 64 patients with inaccessible medical records were excluded. Epidemiological data indicated that the first cases of SARS-CoV-2 infection in the Sichuan cohort occurred in December 31, 2019, and the first case was admitted to the designated hospital on January 16, 2020 (Figure 1C). The daily Wuhan-related exposure cases with onset of COVID-19 in the Sichuan cohort peaked on January 23, 2020, and those without Wuhan-related exposure peaked on February 1, 2020 (Figure 2A and 2B). The median time from illness onset to admission in the Sichuan cohort was significantly shorter than that in the Wuhan cohort (5.0 [2.0, 9.0] vs. 10.0 [7.0, 15.0] days, P <0.001). The Sichuan cohort had a lower proportion of patients with an exposure history than that in the Wuhan cohort (64.3% vs. 99.3%, P <0.001). The demographic and clinical characteristics of these patients are shown in Table 1 and S1. Patients in the Sichuan cohort were younger (44 [32.0, 54.0] vs. 58 [43.0, 67.0] yrs, P <0.001), there were fewer females (46.4% vs. 54.1%, P =0.010), and included a higher number of current smokers (14.5% vs. 5.1%, P <0.001). Two patients (0.4%) in the Sichuan cohort and 13 (1.8%) in the Wuhan cohort were healthcare workers ( P =0.033). The commonest comorbidity in both cohorts was hypertension (23.6%), followed by diabetes (11.9%). The Wuhan cohort had more cases with comorbidities (51.2% vs. 43.8%, P =0.012) as assessed by the Charlson Comorbidity Index[17] (CCI) (2.0 [2.0, 3] vs. 0 [0, 1.0], P <0.001). Fewer patients in the Sichuan cohort had a history of coronary heart disease ( P =0.004), liver disease ( P <0.001), stroke ( P =0.026), hypertension ( P <0.001), and malignancy ( P =0.012) than those in the Wuhan cohort. Fever was the commonest symptom and was present in 61.8% of patients in the Sichuan cohort or 65.1% of patients in the Wuhan cohort, but the difference was not significant ( P =0.246). The Sichuan cohort had a higher incidence of productive cough than the Wuhan cohort ( P =0.012). However, the Wuhan cohort seemed to have a higher symptomatic burden with regard to the lower respiratory tract, including shortness of breath (25.4% vs. 9.0%, P <0.001), chest distress (23.8% vs. 9.0%, P <0.001), wheeze (13.9% vs. 4.8%, P <0.001), and general symptomatic burden, including fatigue (36.2% vs. 22.3%, P <0.001), hemoptysis (3.0% vs. 1.1%, P =0.028), altered consciousness (1.8% vs. 0.2%, P =0.011), and diarrhea (12.1% vs. 6.3%, P =0.001). In contrast, the Sichuan cohort was more likely to have upper respiratory symptoms, including pharyngalgia (13.9% vs. 7.5%, P <0.001), rhinorrhea (5.0% vs. 1.4%, P <0.001), nasal obstruction (3.4% vs. 1.1%, P =0.007), and headache (10.1% vs. 4.6%, P <0.001) (Figure 3A). Different severity distributions were observed between the two cohorts ( P <0.001), as assessed by CURB-65 and MuLBSTA (both P <0.001). More than 75% of patients in both cohorts had mild or general disease, although the Sichuan cohort had a higher proportion of severe cases (17.0% vs. 8.4%) and the Wuhan cohort had more critically ill patients (13.6% vs. 6.3%). Chest CT radiographs in the Wuhan cohort were more likely to show bilateral lung involvement ( P =0.012) and consolidation ( P =0.006). There was no difference in white blood cell count, lymphocyte count, prothrombin time, albumin, alanine aminotransferase, aspartate aminotransferase, procalcitonin and interleukin 6 (IL-6) between the two cohorts. The Sichuan cohort had lower neutrophil count ( P <0.001), platelet count ( P <0.001), D-dimer levels ( P =0.001), and C-reactive protein levels ( P <0.001) and higher levels of hemoglobin ( P =0.015), activated partial thromboplastin time ( P <0.001), creatinine ( P =0.040), and creatine kinase ( P <0.001) (Table 1). T reatments and clinical outcomes A comparison of treatments and clinical outcomes between the two cohorts is shown in Table 2. Almost all patients received antiviral treatment in Sichuan (94.7%) or Wuhan (93.2%). Fewer patients in the Sichuan cohort received antibiotics ( P <0.001), corticosteroids ( P <0.001) and supplemental oxygen therapy ( P <0.001). The case fatality rate in the Sichuan cohort was obviously lower than that in the Wuhan cohort (0.6% vs. 8.3%, P <0.001). However, there was no significant difference in the proportion of patients receiving noninvasive mechanical ventilation or invasive mechanical ventilation between the two cohorts (5.7% vs. 5.9%, P =0.872 and 1.7% vs. 1.4%, P =0.701). With regard to the secondary outcomes, the proportion of patients who were admitted to the ICU in the Sichuan cohort was significantly lower than that in the Wuhan cohort (6.3% vs. 13.6%, P <0.001). The time from illness onset to ICU admission and time from illness onset to discharge in the Sichuan cohort were shorter than that in the Wuhan cohort (7.0 [4.0, 10.5] vs. 11.5 [8.8, 24.3] days, P <0.001 and 23.0 [18.0, 31.0] vs. 28.0 [18.0, 38.0] days, P <0.001). The length of hospital stay in the Sichuan cohort was much longer than that in the Wuhan cohort (17.0 [12.0, 24.0] vs. 14.0 [9.0, 24.0] days, P <0.001). In contrast, the Wuhan cohort had a significantly prolonged duration of SARS-CoV-2 shedding than that in the Sichuan cohort (19.0 [13.0, 28.0] vs. 14.0 [10.0, 19.0] days, P <0.001). Logistic regression analyses Multivariable logistic regression models were used to explore the differences in clinical outcomes between the Sichuan and Wuhan cohorts (Table 3). The results showed that the Wuhan cohort had higher risk of death (aOR=7.64, 95% CI=[2.31, 25.27], P =0.001), ICU admission (aOR=1.66, 95% CI=[1.05, 2.63], P =0.031), delayed time from illness onset to hospital (aOR=6.29, 95% CI=[4.70, 8.40], P <0.001) and ICU admission (aOR=8.03, 95% CI=[1.74, 37.06], P <0.001) admissions, prolonged duration of viral shedding after COVID-19 onset (aOR=1.64, 95% CI=[1.15, 2.33], P =0.006), a decreased hospital stay (aOR=0.41, 95% CI=[0.32, 0.53], P <0.001) after adjusting for age, sex, smoking status and the CCI. There was no difference in time from illness onset to discharge (aOR=0.99, 95% CI=[0.77, 1.28], P =0.968) after adjusting for these confounders. When we additionally adjusted for time from illness onset to hospitalization, the risk of the Wuhan cohort was nearly unchanged; however, the Sichuan cohort had a lower risk for extended time from illness onset to discharge (aOR=0.46, 95% CI=[0.34, 0.63], P <0.001). In the overall study population of COVID-19 patients from the two cohorts, we constructed multivariable logistic regression models to detect the risk factors at admission for death, ICU admission, mechanical ventilation and duration of viral shedding after COVID-19 onset (Table S2). After adjusting for the cohort sites, sex, age, smoking status and the CCI, we found that white blood cells (>10×10 9 /L), neutrophils (>6.3×10 9 /L), lymphocytes (>1.0×10 9 /L), hemoglobin (0.5 mg/L), creatine kinase (>185 IU/L), hyper-sensitive troponin I (>0.04 ng/mL), alanine aminotransferase (>50 IU/L), aspartate aminotransferase (>40 IU/L), procalcitonin (>0.5 ng/mL) and delayed hospitalization were associated with death, ICU admission and mechanical ventilation. In addition, we found that time from illness onset to hospitalization was associated with prolonged duration of virus shedding (adjusted β=0.11, 95% CI= [0.03, 0.24], P =0.009). We analyzed the relationship between the delay in hospitalization and elevated systemic inflammation and features of organ dysfunction. The time from illness onset to hospitalization was positively correlated with systemic inflammatory cells such as white blood cells (r=0.086, P =0.004), neutrophils (r=0.089, P =0.003), eosinophils (r=0.116, P <0.001), platelets (r=0.212, P <0.001), and inflammatory biomarkers, such as D-dimer (r=0.101, P =0.004), procalcitonin (r=−0.093, P =0.019), features of organ dysfunction, such as hemoglobin (r=−0.155, P <0.001), BUN (r=0.10, P =0.002), creatine (r=−0.094, P =0.003), albumin (r=−0.263, P <0.001), and APTT (r=−0.247, P <0.001) (Table 4). After adjusting for age, the correlations of delay in hospitalization with BUN and D-dimer did not achieve statistical significance, which indicated that the delay in hospitalization was independent of age. We further analyzed the relationship between the delay in hospitalization and ICU admission with elevated systemic inflammation after adjusting for age, sex, smoking, and steroid use. In general, the relationship between the delay in hospitalization and elevated systemic inflammation did not change, which implied that these relationships were independent of age, sex, smoking, and steroid use. Subgroup analyses between Sichuan sub-cohorts with vs. without Wuhan-related exposure There was almost no difference in clinical characteristics and outcomes between the two sub-cohorts with and without Wuhan-related exposure in Sichuan. Detailed information is provided in Supplementary Data (Tables S3, S4 and S5). Sichuan sub-cohort with Wuhan-related exposure vs. Wuhan cohort The differences in the clinical characteristics and outcomes between the Sichuan sub-cohort with Wuhan-related exposure and Wuhan cohort were similar to the differences between the Sichuan and Wuhan cohorts. The results are described in detail in the Supplementary Data (Tables S6, S7 and S8). Discussion To the best of our knowledge, there exists a paucity of information obtained from a comparative large-sample study on the differences in epidemiology, clinical characteristics and outcomes of patients with COVID-19 between the epicenter (Wuhan) and the peripheral areas of pandemic. This comparative study provides important insights. First, the outbreak and transmission of COVID-19 within the region of Sichuan as the peripheral epidemic area has been well contained within two months through the use of traditional public health outbreak response tactics. Second, the Sichuan cohort is characterized by a higher incidence of upper airway symptoms, whereas the Wuhan cohort was older, had fewer lower airway symptoms and comorbidities, and had elevated pivotal systemic inflammation indicative of organ dysfunction as well as worse clinical outcomes independent of sex, age, smoking and comorbidities. Third, the subgroup analysis indicated that, within the Sichuan cohort, the patients with Wuhan-related exposure had similar clinical features and outcomes to those with non-Wuhan-related exposure. Fourth, the Wuhan-related exposure patients in the Sichuan cohort had better clinical outcomes than those in the Wuhan cohort, although these two groups of patients had a similar Wuhan-related exposure history. As indicated in recently published studies[12], the COVID-19 patients in Wuhan, at the epicenter area of the epidemic, were older, had more co-existing conditions assessed by the CCI, had extended time from illness onset to hospitalization, and included more severely ill patients. However, the Sichuan cohort, as the peripheral area, had some characteristics features. First, there were fewer healthcare workers in the Sichuan cohort than in the Wuhan cohort, which could be at least partially explained by the insufficient implementation of precautions and the overwhelmed health system during the earlier stage of this outbreak in Wuhan. Second, intriguingly, there was a higher incidence of upper airway symptoms, rather than high incidence of lower airway symptoms in the Wuhan cohort at the epicenter epidemic, which was similar to the findings from exported cases in Singapore[18]. Accordingly, the exported patients from the epicenter were usually diagnosed with a “common cold” at the beginning of the COVID-19 outbreak. The different populations, the airway proliferation location, or the evolution of SARS-CoV-2 possibly could account for these differential symptoms[18-21]. Third, within the consecutively recruited cases in the Sichuan cohort as a well-defined population, the subgroup analyses indicated a higher proportion of males and older patients among the non-Wuhan-related exposure patients, which supported the theory of the propensity for SARS-CoV-2 infection in males and elders[9, 22, 23]. Recent studies from the USA and Italy have reported that a greater proportion of elderly and male COVID-19 patients would experience more critical illness[24, 25]. Until now no antiviral treatment for COVID-19 has proven effective, and supportive care is the mainstay of treatment is. Compared with the Wuhan cohort, the use of antibiotics (i.e. cephalosporin and quinolones) and glucocorticoids in the Sichuan cohort decreased by 26.4% and 16.1%, respectively. These results could possibly be explained as follows. First, as indicated earlier, the expert panel drawn from the multidisciplinary team established by HCSP together developed and adjusted the treatment plan for severely or critically ill patients according to the interim guidance from the National Health Commission of China and the WHO across the 208 designated hospitals in Sichuan by using the 5G network every day. Accordingly, the use of systemic corticosteroids was strictly managed and they were not routinely administered for the treatment of COVID-19 patients. Second, the COVID-19 patients in the Wuhan cohort would actually be more severe or critically ill, which was supported by the increased use of supplemental oxygen in case of acute hypoxia. In addition, prone-position ventilation, physical rehabilitation and a variety of traditional Chinese medicines were used more often in Sichuan under the guidance of the expert panel; however, this aspect needs to be investigated further in randomized controlled trials[7, 8]. In terms of clinical outcomes, several important findings were identified in this study. An epidemic outbreak provided an opportunity to obtain important information, some of which were associated with a limited window of opportunity. This study showed that there was a delay from illness onset to hospitalization in the Wuhan cohort, which might be an important risk factor for the progression of COVID-19. Multivariate regression analysis showed that the time from illness onset to hospitalization was significantly associated with mortality and ICU admission, which suggested some important implications with regard to the pathogenesis of SARS-CoV-2 and may provide insights into a unique window of opportunity for intervention[7]. Liang et al .[12] recently found that Wuhan-related exposure patients have worse clinical outcomes compared with the non-Wuhan-related exposure cases; they attributed the attenuated disease to the onward transmission of SARS-CoV-2. In fact, this is paradoxical to the findings reported from Liang et al .’s study[12] because the relationship between Wuhan-related exposure and prognosis disappeared after adjusting for confounders. Our study firstly found that COVID-19 patients in the Wuhan cohort had worse clinical outcomes including case fatality rate, ICU admission, and duration of virus shedding, independent of sex, age, smoking, comorbidities, and even time from illness onset to hospitalization. The severity of COVID-19 and the shortage of medical resources would partly account for these worse outcomes. For example, during an earlier stage of the outbreak, some patients would not have received sufficient oxygen support because of insufficient oxygen pressure. The duration of infectious virus replication is an important factor in assessing the risk of transmission and for guiding decisions on the isolation of patients; however, the duration of SARS-CoV-2 RNA detection has not been well explored. Our study found that the Wuhan cohort in the epicenter area had the prolonged virus shedding, which may contribute to the disease severity and clinical course[26, 27]. Furthermore, we found for the first time that the duration of virus shedding was independently associated with age and time from illness onset to hospitalization. Our findings are supported by those of other studies. Liu et al .[28] found that the viral load in severe cases was higher than that of mild cases, which had early viral shedding. Wolfel et al .[29] found that virus shedding in the upper airway, which is the location of mild COVID-19, was very high during the first week of symptoms, whereas shedding of viral RNA from sputum derived from the lower airway, which is the region of general to critical illness in COVID-19, outlasts the disappearance of symptoms. Xu et al .[30] found that elderly patients had prolonged virial shedding, but the correlation of age with the duration of viral shedding disappeared after adjusting for confounders, although this might be partly attributed to the small sample size. As the pandemic evolves, mutations and natural selection of SARS-CoV-2 inevitably occur, although this virus a lower mutation rate than that of other RNA viruses[31]. The China National Center for Bioinformation aligned 77,801 genome sequences of SARS-CoV-2 that were detected globally and identified a total of 15,018 mutations[32]. Studies have shown that mutations play an important role in the virulence and infectivity of SARS-CoV-2, although no significant association was found between mutations and outcomes pertaining to hospitalization or death[33-35]. Thus, it is unclear whether the different clinical outcomes of patients with COVID-19 between the epicenter and peripheral areas affected by the pandemic are due to mutations in SARS-CoV-2. This large-sample comparative study provides informative insights into the differences in epidemiology, clinical characteristics and outcomes of patients with COVID-19 between the epicenter (Wuhan) and peripheral (Sichuan) areas of the pandemic. However, there are several limitations that need to be addressed. First, due to the retrospective study design, data generation was clinically driven, and not all laboratory data were available for all patients. Accordingly, the missing data for some patients may have biased the findings. Second, the Sichuan cohort, which represented the peripheral area of the COVID-19 pandemic, was incomplete although consecutive patients accounting for 88.1% of total cases with COVID-19 were recruited from 41 designated hospitals in Sichuan. Third, we did not analyze the genetic diversity of virus strains and the evolutionary history, which might well explain the differences between the epicenter and peripheral areas affected by the pandemic. Conclusions This comparative study found that there were significant differences in the epidemiology, clinical characteristics, and outcomes of patients with COVID-19 between the epicenter and peripheral areas affected by the pandemic. The worse outcomes in the epicenter could be partly explained by the overwhelming of health systems and the delayed time from illness onset to hospitalization. This was associated with elevated systemic inflammation, organ dysfunction and prolonged duration of virus shedding, independent of sex, age, smoking and comorbidities. This has potential implications that are of clinical relevance in interventions for COVID-19. The data suggests that urgent or early supportive care would achieve improved clinical outcomes, leading to a lower death rate although no proven effective therapies currently exist. No differences were found in the epidemiology, clinical characteristics, and outcomes between the first generation and secondary generation of patients in the peripheral area of pandemic. Biological differences accounting for the differences between the Wuhan-related exposure patients in the Sichuan cohort and Wuhan cohort need to be further investigated. List Of Abbreviations aOR: adjusted odds ratio CCI: Charlson comorbidity index CI: confidence interval COVID-19: coronavirus disease 2019 HCSP: The Health Commission of Sichuan Province ISARIC: International Severe Acute Respiratory and Emerging Infection Consortium OR: odds ratio SARS-CoV-2: severe acute respiratory syndrome coronavirus 2 WHO: world health organization Declarations Ethics approval and consent to participate The Biological and Medical Ethics Committee of West China Hospital (approval number: 2020-304 and 2020-126) and the Ethic Committee of Renmin Hospital of Wuhan University (approval number: WDRY2020-K068) granted ethical approval for this study. Administrative permission to access the raw data was granted by administrators of each hospital. Written informed consent from each participant was waived for design of a retrospective study. The data used in this study was anonymised before its use. Consent for publication Not applicable. Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Competing interests The authors declare that they have no competing interests. Funding This study was supported by the Sichuan Provincial Program for Diagnostic and Treatment of COVID-19 (No. 2020YFS002 and 2020YFS005), and the National Key Development Plan for Precision Medicine Research (2017YFC091004), and the National Natural Science Foundation of China (No. 81920108002). Funding sources played no role in the study design, data analysis, decision to publish, or preparation of the manuscript. Author's contributions GW, FML, DL, JSL, NX, JFL, ZAL, WML had roles in the study design, data analysis, data interpretation, and writing of the manuscript. YW, HC, PWT, TF, LT, HY, LW, MF, ZN, BW, ZFS, XLW, HJW, XT, MX, XYL, BL, CJ, JX, JS had roles in the collection, processing, cleaning, and interpretation of data. All authors read and approved the final manuscript. Acknowledgments We would like to thank all the patients who donate their data for this analysis and all medical staffs working in the front line for taking care of the patients. We show thanks to Dr. Xuan Zhang, PhD, Dr. Xin Zhang, MD, Dr. Ting Wang, MD, and Dr. Ji Wang, MD, for their statistical analyses and editing work. We are indebted to the coordination of Ms. Jun Hua Li from the Health Commission of Sichuan Province, and Mr. Nian Li and Ms. Bei Bai from West China Hospital, Sichuan University, who greatly facilitate the collection of patients’ data. We appreciate the expert panel from multiple disciplines team as follows: (1) Respiratory and Critical Care Medicine: Zong An Liang, Feng Min Luo, Chun Tao Liu, Hong Fan, Dan Liu, He Yu at West China Hospital, Sichuan University, Yang Yang from Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital ,Song Ping Wang, Wen Jun Wang from Affiliated Hospital of Southwest Medical University, Xiao Ju Chen, Li Jiang at Affiliated Hospital of North Sichuan Medical College, Zhen Liang Xiao at General Hospital of Western War Zone, Qing Song Huang, Yan Dong at Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, De Hai Yu from the Second Traditional Chinese Medicine Hospital of Sichuan, Xiao Hui Zhang from Sichuan Integrative Medicine Hospital, Su Hua Ao from Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Yong Sheng Wang from The first People's Hospital of Chengdu, Guo Ping Li from The Third People's Hospital of Chengdu, Ya Lin Liu, Gui Hui Wu at Public Health Clinical Center of Chengdu, Wei Guo Xu from Mianyang Central Hospital, Zheng Guang He from Suining Central Hospital; (2) Nosocomial infection: Zhi Yong Zong, Wei Jia Yin at West China Hospital, Sichuan University, Jian Jun Deng at The Second West China Hospital, Sichuan University, Jia Yu Wu at Sichuan Provincial Peoples Hospital, Rong Li Wang, Jiao Xia at The affiliated hospital of Southwest Medical University, Zong Ying Jing at The TSC hospital of Southwest Medical University, Yong Fang Liu, Bi Feng Xu at The affiliated hospital of North Sichuan Medical College, Zhang Chen at The General Hospital of Western theater Command, Wen Sheng Zhang at Affiliated Hospital of Chengdu University of TCM, Hua Guo at Chengdu Third People`s Hospital, Ping Chen, Xiao Fei Duan at Public Health and Clinical Center of Chengdu, Chun Hua Ma at Mianyang 404 Hospital; (3) Radiology: Bin Song, Hong Li Bai, Jian Qun Yu at West China Hospital, Sichuan University, Jin Jiang at Sichuan Provincial Peoples Hospital, Jian Shu, Fu Gang Hang at The affiliated hospital of Southwest Medical University, Tian Wu Chen, Qiong Hui Zhao at The affiliated hospital of North Sichuan Medical College, Rui Jiang at The General Hospital of Western theater Command, Ming Guo Xie at Affiliated Hospital of Chengdu University of TCM, Bin Yang at The TSC hospital of Southwest Medical University, Na Zhang, Xin Wei Wang at Public Health and Clinical Center of Chengdu, Qi Yu Liu at Mianyang Central Hospital; (4) Department of Laboratory Medicine: Kang Mei, Xie Yi at West China Hospital, Sichuan University, Jiang Li, Yu Hua from Sichuan Provincial People’s Hospital ,Liu Jin Bo, Li Bao Lin from Affiliated Hospital of Southwest Medical University, Zhang Guo Yuan, Huang Yi Shan from Affiliated Hospital of North Sichuan Medical College, Hu Zong Hai, Dan Gang from the General Hospital of Western Theater Command, Xiong Da Qian from Chengdu University of Traditional Chinese Medicine, Guo Yong Can from Southwest Medical University of Traditional Chinese Medicine, Li Qing Feng, Cao Ling from the Public Health Clinical Center of Chengdu; (5) Diagnosis and Treatment of Infectious Diseases: Tang Hong, Feng Ping, Lv Xiao Ju, Bai Lang at West China Hospital, Sichuan University, Yang Xing Xiang from Sichuan Provincial People’s Hospital, Huang Yong Mao, Huang Fu Li from Affiliated Hospital of Southwest Medical University, Xiong Liang Shi, Liu Feng Jun from Affiliated Hospital of North Sichuan Medical College, Zhang Ling ,Zeng Yi Lan from the General Hospital of Western Theater Command, He Sheng Hua from the Public Health Clinical Center of Chengdu;(6) Critical Care Medicine: Yan Kang, Xiao Dong Jin, Zhong Wei Zhang at West China Hospital, Sichuan University, Xiao Bo Huang from Provincial People’s Hospital, Xian Ying Lei, Chang Xue Wu at the Affiliated Hospital of Southwest Medical University, Ying Ge, Da Qing Wang at the Affiliated Hospital of North Sichuan Medical College, Fu Xiang Li, Zhang Wang at the General Hospital of Western Theater Command, Pei Yang Gao from Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Xiao Bin Li from Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University, Yun Feng Chen from Chengdu Integrated Traditional Chinese Medicine & Western Medicine Hospital, Chuan Zhang from Chengdu Third People’s Hospital, Hong Chen, Hong De Chen, Ling Zhang at Chengdu Public Health Clinical Medical Center; (7) Emergency treatment: Jun Zeng, Ping Zhou, Xiao Mei Wang at Provincial People’s Hospital, Yu Cao from West China Hospital, Sichuan University, Wu Zhong, Ying Liu at the Affiliated Hospital of Southwest Medical University, Shi Ping Liu, Zhi Jiang at the Affiliated Hospital of North Sichuan Medical College, Gui Sen Xu from the General Hospital of Western Theater Command, Yun Lu, Xiao Yun Zhang at Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Zhi Hong Zhang from Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University, Yu Fei Hou from Chengdu Emergency Command Center, Wen Jun Li, Bo Leng at Chengdu Public Health Clinical Medical Center; (8) Traditional Chinese Medicine: Shao Hong Chen, Cheng Shi He,Xiao Yu Hu, Kun Yang at Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Gang Suo from Sichuan Provincial Orthopedics Hospital. We also show thanks to Li Yan A, Ling Chen, Jing Yu Cui, Ke Deng, Su Jun Deng, Xue Mei Fang, Min Feng, Xiao Min Fu, Yu Yu Han, Jia Xin Hou, Yue Hong Hu, Dan Huang, Qiao Yun Huang, Min Li, Ren Jiao Li, Xiao Qian Li, Yu Qi Li, Jun Zhe Liao, Ping Lin, Zhi Lin, Dan Liu, Jia Liu, Lei Liu, Sha Liu, Shi Yao Liu, Zhi Hao Liu, Ya Lan Luo, Zhi Wen Ma, Min Qi, Xing Yu Qiu, Fang Yu Shi, Tao Lin Qin, Xiao Ju Tang, Rui Tian, Xin Tian, Dan Wang, Ji Wang, Qin Wang, Ting Wang, Yi Wei Wang, Yu Wang, Jia Hao Wu, Wen Wen Wu, Lin Rui Xu, Zhuan Hua Yang, Dong Fan Ye, Yuan Ye, Ze Lin Yin, Yu Lai Yuan, Jing Xuan Zhang, Liang Liang Zhang, Xin Zhang, Ya Li Zhang, Yu Yang Zhang, Yu Chen Zhang, Li Chun Zhong, Qiao Zhou, Yu Yan Zhou, Wen Juan Zhu, Wen Jun Zhu, Ying Ying Zhu, En Qiang Chen, Ming Jin Dai, Hui Gao, Hong Bo Jia, Yang Li, Min Tao Lin, Qi Liu, Lu Lu, Ruo Ting Men, Zhi Ming Ni, Da Nan Pan, Yuan Ya Qin, Tian Rui Ren, Si Si Shen, Yan Jun Si, Jia Jia Song, Xing Bo Song, Li Yi Wang, Wen Xiu Wang, Yong Wang, Xi Zhan Weng, Qin Wu, Yu Jie Wu, Xian Xing, Rong Fang Yan, Zhi Qing Yan, Lan Yang, Le Tian Yang, Ying Ying Yang, Jia Yu Ye, Ling Zhang, Qi Zhang, Sheng Zhang, Ying Teng Zhang, Ying Ying Zhang, Yu Wei Zhang, Han Jiang Zeng for their dedication to data entry and verification. We also show thanks to hospitals who recruited the included cases as following: West China Hospital of Sichuan University, The Public Health Clinical Center of Chengdu, People’s hospital of Jianyang, Pidu District People’s Hospital of Chengdu, Zigong First People’s Hospital, Jintang County First People’s Hospital, People’s Hospital of Deyang City, Sichuan Mianyang 404 Hospital, The Third People’s Hospital of Guangyuan, The Fourth People’s Hospital of Panzhihua, Luzhou Infectious Diseases Hospital, Suining Central Hospital, The First People’s Hospital of Neijiang, Neijiang Second Municipal People’s Hospital, People’s Hospital of Leshan, Affiliated Hospital of North Sichuan Medical College, The Second People’s Hospital of Yibin, Linshui County Peoples’s Hospital of Guangan, Yuechi County Peoples’s Hospital, Guang’an People’s Hospital (West China-Guang’an Hospital, Sichuan University), People’s Hospital of Huaying, Dazhou Central Hospital, Bazhong Central Hospital, Third Branch of Yaan People’s Hospital (Hospital of Infectious Diseases), Meishan City People’s Hospital, The First People’s Hospital of Ziyang, The First People’s Hospital of Liangshan Yi Autonomous Prefecture, Ganluo County People’s Hospital of Liangshan Yi Autonomous Prefecture, People’s Hospital of Aba Tibetan and Qiang Autonomous Prefecture, Ganzi Tibetan Autonomous Prefecture People’s Hospital, Nanchong Central Hospital, Pengan County People’s Hospital, People’s Hospital of Langzhong, Nanbu County People’s Hospital, The Fifth People’s Hospital of Nanchong, Yilong County People’s Hospital, Yingshan County People’s Hospital, Pinchang County People’s Hospital, Tongjiang County People’s Hospital, Medical Center Hospital of Qionglai, Jiangyou Infectious Diseases Hospital. References Wenjie T, Xiang Z, Xuejun M, Wenling W, Peihua N, Wenbo X, George FG, Guizhen W: A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases — Wuhan, China 2019−2020. China CDC Weekly 2020, 2(4):61-62. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020, 395(10223):497-506. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y et al: Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA 2020. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y et al: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020, 395(10223):507-513. Zeng Y, Li DJ, Zong ZY, Jiang Y, on behalf of Sichuan Medical Treatment Expert Group for Covid-19: The emergency prevention and control guidelines for Covid-19 in medical institutions of Sichuan province. In.: Sichuan Science and Technology Press; 2020. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, Rubin GJ: The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020, 395(10227):912-920. Fauci AS, Lane HC, Redfield RR: Covid-19 - Navigating the Uncharted. N Engl J Med 2020, 382(13):1268-1269. Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB: Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. JAMA 2020. Cai Q, Huang D, Ou P, Yu H, Zhu Z, Xia Z, Su Y, Ma Z, Zhang Y, Li Z et al: COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy 2020. Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, Li SB, Wang HY, Zhang S, Gao HN et al: Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ 2020, 368:m606. Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, Chen H, Wang D, Liu N, Liu D et al: Characteristics of COVID-19 infection in Beijing. J Infect 2020, 80(4):401-406. Liang WH, Guan WJ, Li CC, Li YM, Liang HR, Zhao Y, Liu XQ, Sang L, Chen RC, Tang CL et al: Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): A Nationwide Analysis of China. Eur Respir J 2020. WHO. Novel Coronavirus–China. 2020. https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/2020. Accessed May 8 2020. Wei JF, Huang FY, Xiong TY, Liu Q, Chen H, Wang H, Huang H, Luo YC, Zhou X, Liu ZY et al: Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis. Heart 2020, 106(15):1154-1159. Xiong W, Mu J, Guo J, Lu L, Liu D, Luo J, Li N, Liu J, Yang D, Gao H et al: New onset neurologic events in people with COVID-19 infection in three regions in China. Neurology 2020. Xiong TY, Huang FY, Liu Q, Peng Y, Xu YN, Wei JF, Li N, Bai B, Li JH, Prendergast B et al: Hypertension is a risk factor for adverse outcomes in patients with coronavirus disease 2019: a cohort study. Ann Med 2020:1-20. Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987, 40(5):373-383. Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM et al: Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA 2020. Li X, Wang W, Zhao X, Zai J, Zhao Q, Li Y, Chaillon A: Transmission dynamics and evolutionary history of 2019-nCoV. J Med Virol 2020, 92(5):501-511. Zhang J, Litvinova M, Wang W, Wang Y, Deng X, Chen X, Li M, Zheng W, Yi L, Chen X et al: Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study. Lancet Infect Dis 2020. Rubens JH, Karakousis PC, Jain SK: Stability and Viability of SARS-CoV-2. N Engl J Med 2020, 382. Liu Y, Mao B, Liang S, Yang JW, Lu HW, Chai YH, Wang L, Zhang L, Li QH, Zhao L et al: Association between ages and clinical characteristics and outcomes of coronavirus disease 2019. Eur Respir J 2020. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X et al: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020, 395(10229):1054-1062. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, and the Northwell C-RC, Barnaby DP, Becker LB, Chelico JD et al: Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA 2020. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R et al: Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA 2020. Liu Y, Yan LM, Wan L, Xiang TX, Le A, Liu JM, Peiris M, Poon LLM, Zhang W: Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis 2020. Zhou B, She J, Wang Y, Ma X: The duration of viral shedding of discharged patients with severe COVID-19. Clin Infect Dis 2020. Liu Y, Eggo RM, Kucharski AJ: Secondary attack rate and superspreading events for SARS-CoV-2. Lancet 2020, 395(10227):e47. Wolfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Muller MA, Niemeyer D, Jones TC, Vollmar P, Rothe C et al: Virological assessment of hospitalized patients with COVID-2019. Nature 2020. Xu K, Chen Y, Yuan J, Yi P, Ding C, Wu W, Li Y, Ni Q, Zou R, Li X et al: Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clin Infect Dis 2020. Zhao Z, Sokhansanj BA, Malhotra C, Zheng K, Rosen GL: Genetic grouping of SARS-CoV-2 coronavirus sequences using informative subtype markers for pandemic spread visualization. PLoS Comput Biol 2020, 16(9):e1008269. Hu B, Guo H, Zhou P, Shi ZL: Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol 2020. Chen J, Wang R, Wang M, Wei GW: Mutations Strengthened SARS-CoV-2 Infectivity. J Mol Biol 2020, 432(19):5212-5226. Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B et al: Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell 2020, 182(4):812-827 e819. Nakamichi K, Shen JZ, Lee CS, Lee AY, Roberts EA, Simonson PD, Roychoudhury P, Andriesen JG, Randhawa AK, Mathias PC et al: Outcomes associated with SARS-CoV-2 viral clades in COVID-19. medRxiv 2020. Tables Table 1. Demographics and clinical characteristics of patients in the Sichuan and Wuhan cohorts Variable Total Sichuan cohort Wuhan cohort χ 2 /Z P value n 1184 474 710 Female, n (%) 604 (51.0) 220 (46.4) 384 (54.1) 6.693 0.010 Age, years (Median [IQR]) 50.50(37.00,64.00) 44.00(32.00,54.00) 58.00(43.00,67.00) 12.054 <0.001 Travel in Wuhan/residence in Wuhan/no exposure history, n 141/869/174 128/177/169 13/692/5 527.493 <0.001 Health care workers, n (%) 15 (1.3) 2 (0.4) 13 (1.8) 4.532 0.033 Current/ ever/ never smoking, n 96/42/892 67/18/376 29/24/516 26.843 <0.001 Any comorbidity 574 (48.2) 208 (43.8) 366 (51.2) 6.258 0.012 Charlson Comorbidity Index 1.0 (0-2.0) 0 (0-1.0) 2 (2.0-3.0) -9.190 <0.001 Disease severity status, n 97.524 <0.001 Mild/general/severe/critical 194/725/141/127 28/337/81/30 166/388/60/97 CURB-65 score, n (%) 0-1/2/3-5 837/68/20 369/12/2 468/56/18 26.430 <0.001 MuLBSTA score (Median [IQR]) 7.00(5.00,9.00) 5.00(5.00,9.00) 7.00(5.00,9.00) 3.96 <0.001 Laboratory findings, Median (IQR) White blood cell count, ×10⁹ /L 5.45(4.22,7.07) 5.37(4.18,5.37) 5.58(4.22,7.28) 1.570 0.088 Neutrophil count, ×10⁹ /L 3.45(2.50,4.99) 3.45(2.53,4.73) 3.45(2.47,5.26) 2.723 <0.001 Lymphocyte count, ×10⁹ /L 1.18(0.83,1.63) 1.18(0.81,1.60) 1.18(0.84,1.64) 1.074 0.157 Eosinophil count, ×10⁹ /L 0.30(0.00,1.30) 0.20(0.01,0.80) 0.50(0.0,1.7) 5.751 <0.001 Hemoglobin, g/L 131.00(119.00,144.00) 137.00(126.00,151.00) 127.00(117.00,137.00) 8.049 0.015 Platelet count, ×10⁹ /L 197.00(148.00,262.50) 175.00(137.00,230.50) 215.00(165.00,281.00) 7.909 <0.001 Activated partial thromboplastin time, s 28.50(25.90,32.20) 30.90(27.70,34.90) 27.40(25.20,29.90) 10.129 <0.001 Prothrombin time, s 12.20(11.50,13.00) 12.60(11.70,13.30) 12.00(11.33,12.70) 2.052 0.115 D-dimer, mg/L 0.56(0.29,1.59) 0.50(0.22,1.17) 0.63(0.33,1.79) 3.194 0.001 Albumin, g/L 39.70(35.50,43.30) 43.00(39.60,45.70) 37.70(34.00,40.80) 11.556 0.128 Creatinine, μmol/L 63.00(51.00,76.15) 65.20(53.00,77.33) 62.00(50.70,75.00) 2.051 0.040 Creatine kinase, U/L 62.70(41.00,106.25) 71.00(50.00,122.00) 56.00(34.40,99.00) 5.181 <0.001 Alanine aminotransferase, U/L 23.55(16.00,39.05) 24.00(16.00,39.90) 23.00(15.48,39.00) 0.433 0.665 Aspartate aminotransferase, U/L 25.00(19.67,35.73) 25.60(20.00,35.00) 25.00(19.00,36.00) 0.459 0.647 C-reactive protein, mg/L 19.95(6.80,53.92) 10.16(2.67,24.72) 28.45(8.70,65.20) 6.066 <0.001 Procalcitonin, ng/mL 0.05(0.04,0.12) 0.06(0.04,0.17) 0.05(0.03,0.11) 2.06 0.039 Hypersensitive troponin I, pg/ml 0.01(0.01,0.01) 0.01(0.01,0.01) 0.02(0.01,0.05) 3.615 <0.001 Chest CT, n (%) Bilateral lungs involvement 741 (93.1) 328 (90.6) 413 (95.2) 6.363 0.012 Consolidation 180 (19.6) 73 (16.0) 107 (23.2) 7.533 0.006 Ground-glass opacity 666 (71.3) 328 (71.6) 338 (71.0) 0.042 0.837 Linear opacity 257 (27.8) 112 (24.5) 145 (31.2) 5.200 0.023 Pleural effusion 49 (5.4) 19 (4.2) 30 (6.6) 2.559 0.110 CT, computed tomography Table 2. Treatments and outcomes of the patients in the Sichuan and Wuhan cohorts Variable Total Sichuan cohort Wuhan cohort χ 2 /Z P value n 1184 474 710 Treatments, n (%) Antiviral treatment 1110 (93.8) 448 (94.7) 662 (93.2) 1.067 0.302 Antibiotics 698 (59.0) 204 (43.0) 494 (69.6) 82.734 <0.001 Antifungal treatment 35 (3.0) 15 (3.2) 20 (2.8) 0.120 0.729 Corticosteroids 272 (23.0) 63 (13.3) 209 (29.4) 41.872 <0.001 Intravenous immunoglobin 9 (0.8) 3 (0.6) 6 (0.8) 0.170 0.680 Oxygen therapy 791(66.9) 273 (57.7) 518 (731) 30.175 <0.001 Prone-position ventilation 30 (2.5) 22 (4.6) 8 (1.1) 14.217 <0.001 Tracheotomy 8 (0.7) 4 (0.8) 4 (0.6) 0.720* ECMO 3 (0.3) 1 (0.2) 2 (0.3) 1.000* Renal replacement 9 (0.8) 5 (1.1) 4 (0.6) 0.497* Blood transfusion 165 (14.0) 30 (6.3) 135 (19.1) 38.587 <0.001 Nutrition support 131 (11.1) 52 (11.0) 79 (11.2) 0.014 0.906 TCM treatments 912 (77.0) 418 (88.2) 494 (69.6) 55.620 <0.001 Physiotherapy 29 (2.4) 24 (5.1) 5 (0.7) 22.605 <0.001 Outcomes Death, n (%) 62 (5.2) 3 (0.6) 59 (8.3) 33.758 <0.001 ICU admission, n (%) 127 (10.7) 30 (6.3) 97 (13.7) 15.961 <0.001 Noninvasive mechanical ventilation, n (%) 69 (5.8) 27 (5.7) 42 (5.9) 0.025 0.875 Invasive mechanical ventilation, n (%) 18 (1.5) 8 (1.7) 10 (1.4) 0.148 0.700 Time from illness onset to hospitalization, days 8.00(4.00,13.00) 5.00(2.00,9.00) 10.00(7.00,15.00) 13.626 <0.001 Hospital stay, days 16.00 (9.00,24.00) 17.00 (12.00,24.00) 14.00(9.00, 24.00) -2.726 <0.001 Time from illness onset to ICU admission, days 9.00(6.00,17.00) 7.00(4.00,10.50) 11.50(8.75,24.25) 3.192 a <0.001 Time from hospitalization to ICU admission, days 3.00(0.00,9.00) 4.00(0.00,9.00) 3.00(0.00,10.50) 0.415 0.678 Time from illness onset to discharge, days 26.00(18.00,35.00) 23.00(18.00,31.00) 28.00(18.00,38.00) 5.693 <0.001 Time from illness onset to death, days 16.50(13.00,21.75) 13.00 (11, -) 17.00 (13.00,23.50) 1.240 a 0.235 Time from hospital admission to death, days 5.00(3.00,7.00) 10.00(6.00,-) 4.00(3.00,7.00) 1.427 0.153 Duration of viral shedding, days 14.00(9.00，22.00) 13.00(8.00,18.00) 17.00(11.00,27.00) 6.665 <0.001 * Fisher's exact test. ECMO, extracorporeal membrane oxygenation; TCM, traditional Chinese medicine. Table 3. Risk of adverse outcomes in Wuhan cohort in reference to the Sichuan cohort Outcomes Unadjusted Adjusted a OR 95%CI P OR 95%CI P Death 14.286 4.444- 45.455 <0.001 7.643 2.311-25.274 0.001 ICU admission 2.347 1.531-3.597 <0.001 1.659 1.047-2.627 0.031 Non-invasive mechanical ventilation 1.044 0.635-1.718 0.865 0.651 0.376-1.127 0.125 Invasive mechanical ventilation 0.835 0.327-2.132 0.705 0.381 0.138-1.054 0.063 Tracheotomy 0.668 0.166-2.681- 0.569 0.225 0.050-1.015 0.052 Time from illness onset hosp italization (>5 days) 6.849 5.208-9.009 <0.001 6.289 4.695-8.403 17 days) 0.481 0.380-0.609 <0.001 0.411 0.316-0.533 7 days) 6.364 1.836-22.061 0.027 8.030 1.740-37.057 23 days) 1.180 0.935-1.489 0.163 0.995 0.772-1.281 0.968 Time from illness onset to death (>10 days) 4.706 0.399-55.447 0.218 4.731 0.314-71.265 0.261 Time from hospitali zation to ICU admission (>4 days) 0.857 0.243-3.024 0.811 0.665 0.122-3.620 0.637 Time from hospital admission to death (>10 days) 0.426 0.035-5.161 0.502 0.155 0.007-3.694 0.249 Duration of viral shedding (> 13 days) 1.881 1.363-2.597 <0.001 1.640 1.153-2.333 0.006 a Adjusted for s ex , age, smoking and Charlson Comorbidity Index. ICU, intensive care unit; CI, confidence interval; OR, odds ratio Table 4. Correlation of time from illness onset to hospitalization with systemic inflammation and features of organ dysfunction Variables Model 1 Model 2 Model 3 Model 4 r P value r P value r P value r P value White blood cell count, ×10⁹/L 0.086 0.004 0.081 0.007 0.082 0.007 0.080 0.008 Neutrophil count, ×10⁹/L 0.089 0.003 0.061 0.044 0.064 0.035 0.061 0.046 Lymphocyte count, ×10⁹/L −0.026 0.391 0.027 0.380 0.025 0.414 0.032 0.293 Eosinophil count, ×10⁹/L 0.116 <0.001 0.119 <0.001 0.118 <0.001 0.127 <0.001 Hemoglobin, g/L −0.155 <0.001 −0.100 0.001 −0.104 0.001 −0.103 0.001 Platelet count, ×10⁹ /L 0.212 <0.001 0.225 <0.001 0.223 <0.001 0.225 <0.001 BUN, mmol/L 0.100 0.002 0.038 0.247 0.040 0.215 0.039 0.226 Creatinine, μmol/L −0.094 0.003 −0.117 <0.001 −0.141 <0.001 −0.141 <0.001 Creatine kinase, U/L −0.155 <0.001 −0.145 <0.001 −0.165 <0.001 −0.166 <0.001 Albumin, g/L −0.263 <0.001 −0.200 <0.001 −0.194 <0.001 −0.192 <0.001 APTT, s −0.247 <0.001 −0.216 <0.001 −0.212 <0.001 −0.212 <0.001 PT, s −0.018 0.600 −0.019 0.567 −0.021 0.537 −0.021 0.535 D-dimer, mg/L 0.101 0.004 0.043 0.210 0.047 0.175 0.046 0.182 C-reactive protein, mg/L 0.051 0.210 0.021 0.619 0.017 0.674 0.014 0.731 Procalcitonin, ng/mL −0.093 0.019 −0.123 0.002 −0.130 0.001 −0.135 0.001 IL-6, pg/mL −0.094 0.407 −0.155 0.171 −0.144 0.211 −0.144 0.215 Model 1: Unadjusted; Model 2: Adjusted for age; Model 3: Adjusted for age, sex, smoking; Model 4: Adjusted for age, sex, smoking, and use steroid use APTT, activated partial thromboplastin time; PT, prothrombin time; BUN, blood urea nitrogen Supplementary Files INFDD2002747R2SupplementaryDatarevised20201213wj1.pdf Cite Share Download PDF Status: Published Journal Publication published 24 Feb, 2021 Read the published version in BMC Infectious Diseases → Version 3 posted Submission checks completed at journal 19 Dec, 2020 Editorial decision: Accept 17 Dec, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-52333","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":6782813,"identity":"7ecb9e19-6553-46f7-ad47-a40784b0fe61","order_by":0,"name":"Gang Wang","email":"","orcid":"","institution":"West China Hospital","correspondingAuthor":false,"prefix":"","firstName":"Gang","middleName":"","lastName":"Wang","suffix":""},{"id":6782814,"identity":"20ae26fb-0334-4413-981b-f0eda9df5ef7","order_by":1,"name":"Feng Ming Luo","email":"","orcid":"","institution":"West China 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11:56:10","currentVersionCode":3,"declarations":"","doi":"10.21203/rs.3.rs-52333/v3","doiUrl":"https://doi.org/10.21203/rs.3.rs-52333/v3","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12879-020-05728-7","type":"published","date":"2021-02-24T15:00:28+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":4697369,"identity":"d371ec85-02fe-49b6-8de7-81b0991cee04","added_by":"auto","created_at":"2021-01-04 21:25:47","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":282021,"visible":true,"origin":"","legend":"A. Time of illness onset and hospital admission of patients in Wuhan cohort. B. Distribution of patients with COVID-19 in Sichuan cohort. C. Time of illness onset and hospital admission of patients in Sichuan cohort.","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-52333/v3/923c21164dabef9fc58def7a.jpg"},{"id":4697447,"identity":"4f54efd5-3cf2-4a0b-8492-6f632978b92e","added_by":"auto","created_at":"2021-01-04 21:28:47","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":251534,"visible":true,"origin":"","legend":"A. Time of illness onset of patients with or without Wuhan-related exposure in Sichuan cohort. B. Time of hospital admission of patient with or without Wuhan-related exposure in Sichuan cohort. C. The ratio of the number of patients without Wuhan-related exposure to cases with Wuhan exposure in Sichuan cohort.","description":"","filename":"2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-52333/v3/ac0d9b8a36ba0c4a3029fed1.jpg"},{"id":4697368,"identity":"f85bc232-e8a3-4167-b54d-933cc94dcc76","added_by":"auto","created_at":"2021-01-04 21:25:47","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":282587,"visible":true,"origin":"","legend":"A. Symptomatic burden of patients with COVID-19 in Sichuan and Wuhan. B. Kaplan-Meier survival curve for time from illness onset to hospital admission of patients with Covid-19 between Sichuan and Wuhan cohorts. C. Kaplan-Meier survival curve for time from illness onset to ICU admission of patients with Covid-19 in Sichuan and Wuhan cohorts. D. Kaplan-Meier survival curve for time from illness onset to discharge of patients with Covid-19 in Sichuan and Wuhan cohorts. ","description":"","filename":"3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-52333/v3/d73be3140621b75bae22df8f.jpg"},{"id":13643060,"identity":"ff803234-a539-4717-8a36-d50950f34788","added_by":"auto","created_at":"2021-09-17 09:10:00","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":626673,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-52333/v3/d8d70966-adc4-48d0-bdd7-307a71206ada.pdf"},{"id":4697367,"identity":"5ad54622-0624-4e25-a028-3b5d84dc47d5","added_by":"auto","created_at":"2021-01-04 21:25:47","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":390548,"visible":true,"origin":"","legend":"","description":"","filename":"INFDD2002747R2SupplementaryDatarevised20201213wj1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-52333/v3/82a72d15dac5b485b42a6d17.pdf"}],"financialInterests":"","formattedTitle":"Differences in the clinical characteristics and outcomes of COVID-19 patients in the epicenter and peripheral areas of the pandemic from China: a retrospective, large-sample, comparative analysis","fulltext":[{"header":"Background","content":"\u003cp\u003eIn December 2019, an outbreak of pneumonia of unknown cause was identified in Wuhan, the capital of Hubei province in China. A novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which had not been detected previously in humans, was identified subsequently by Chinese scientists as the cause[1]. The disease was named the coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO). The clinical spectrum of COVID-19 appears to be wide, and ranges from self-limited mild upper respiratory tract illness to severe pneumonia causing hospitalization or death. The clinical characteristics of some COVID-19 case series in Wuhan, the epicenter of the pandemic, have been previously reported in detail. The reports indicated that 26% to 33% of patients required intensive care and 4% to 15% died[2-4].\u003c/p\u003e\n\u003cp\u003eAfter the outbreak of COVID-19 in Wuhan, the government of the Sichuan province implemented strict measures to combat COVID-19. The Health Commission of Sichuan Province (HCSP) focused on traditional public health outbreak response tactics, including isolation, quarantine, social distancing, and community containment, as recommended by the National Health Commission of China. All medical resources were allocated by the HCSP to ensure efficient use. An expert panel drawn from multidisciplinary teams was established and comprised 125 physicians who were led by Dr. Wei Min Li and Dr. Zong An Liang (the corresponding authors of this study) since January 15, 2020. This expert panel soon released emergency prevention and control guidelines for COVID-19 in the medical institutions of the Sichuan province[5]. Furthermore, we funded two additional important expert panels with psychological counseling[6] and traditional Chinese medicine as complementary and alternative treatment options[7, 8]. Physicians caring for severely or critically ill patients could receive daily internet consultations with members of the expert panel. There were 208 designated hospitals across Sichuan Province that were accessible for SARS-CoV-2-suspected or -confirmed individuals. This arrangement resulted in improved outcomes in Sichuan province, one of the peripheral areas of the pandemic. In other peripheral areas, 2% to 10.1% of patients needing intensive care, and an approximately 1.0% mortality rate were reported in recently published studies[9-11].\u003c/p\u003e\n\u003cp\u003eThe factors underlying the significantly different clinical outcomes between the epicenter and peripheral areas affected by the pandemic remains largely unexplored. Recently, Liang \u003cem\u003eet al\u003c/em\u003e.[12] observed the clinical characteristics and outcomes of hospitalized patients with COVID-19who were treated in Hubei (epicenter) or outside Hubei (non-epicenter). However, as theirs is a multicenter study, the possibility of selection bias for the included patients cannot be ruled out. Furthermore, hospitalized patients in Hubei but not in Wuhan, would not be well representative of the first-generation COVID-19 cases. Considering the rapidly increasing number of cases with SARS-CoV-2 infection worldwide, the existing research into the differences between the epicenter and peripheral areas of the pandemic in the clinical characteristics and outcomes of COVID-19 patients was insufficient.\u003c/p\u003e\n\u003cp\u003eThis study could provide information that would be potentially helpful in formulating clinical practice recommendations to tackle the COVID-19 pandemic worldwide.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eStudy design and subjects\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis was a retrospective study based on two cohorts evaluated by the Sichuan and Wuhan Collaboration Research Group for COVID-19, China. The Wuhan cohort, drawn from the epicenter area of the pandemic, was formed using a computer-generated simple random sampling method that was applied to enroll subjects from two designated hospitals, namely the Wuhan Red Cross Hospital and Renmin Hospital of Wuhan University, Wuhan, China. The Sichuan cohort, as the group of patients from the peripheral area of the pandemic, consisted of SARS-CoV-2-confirmed patients who were consecutively recruited from 41 designated hospitals until March 12, 2020. Based on the exposure history, we further divided the Sichuan cohort into two sub-cohorts, with or without Wuhan exposure history. All patients enrolled in this study were diagnosed with COVID-19 according to the interim guidance issued by the National Health Commission of China and the WHO[13]. SARS-CoV-2 infection was confirmed by a positive result on a real-time reverse-transcriptase-polymerase-chain-reaction of nasopharyngeal, pharyngeal, throat-swab or sputum specimens. Some of these patients were included in studies reported by Wei \u003cem\u003eet al\u003c/em\u003e.[14], Xiong \u003cem\u003eet al.\u003c/em\u003e[15] and Xiong \u003cem\u003eet al\u003c/em\u003e.[16]; however, their study purposes are significantly different from those of this study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData collection\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe medical records of patients with COVID-19 were reviewed by members of the trained research team. Epidemiological, demographic, clinical, laboratory, radiological, treatment and outcome data were collected by using standardized data collection forms (modified case record form for the clinical characterization of severe acute respiratory infection that was shared by the International Severe Acute Respiratory and Emerging Infection Consortium [ISARIC]) from the electronic medical records. The cutoff date was Mar 12, 2020. We collected details of the exposure history, clinical symptoms and signs, and laboratory findings on admission. Laboratory examinations were performed according to the clinical care needs of the patients. Data on radiological abnormalities were extracted from the selected documentation. Patients were excluded if their medical records were not available. A team of trained researchers abstracted the data and entered the structured spreadsheet. All data were cross-checked.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudy outcomes\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe primary outcomes included death or mechanical ventilation whether or not it involved intensive care unit (ICU) admission. Mechanical ventilation was performed in the ward if ICU admission was not possible due to the overwhelming numbers of COVID-19 patients. The secondary outcomes were the rate of ICU admission, time from illness onset to ICU admission and discharge, length of hospital stay, and duration of viral shedding after COVID-19 onset. Duration of viral shedding was defined to ended when two consecutive negative results with qPCR detection were obtained at time intervals greater than 24 hours. The criteria for discharge were absence of fever for at least 3 days, substantial improvement in both lungs on chest computed tomography (CT), clinical remission of respiratory symptoms and comorbidities, and cessation of SARS-Cov-2.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eContinuous variables were compared using the Student's \u003cem\u003et\u003c/em\u003e test or the Mann-Whitney \u003cem\u003eU\u003c/em\u003e test; categorical variables were compared by the chi-square test or Fisher\u0026rsquo;s exact test as appropriate. Logistic or linear regression was performed to identify clinical variables that were associated with outcomes. The detailed statistical analysis is described in the supplementary data.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eEpidemiological and clinical characteristics at hospitalization\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAs of March 12, 2020, a total of 1979 cases from the two hospitals in Wuhan were identified. The Wuhan cohort included 35.9% (n=710) of all patients from Wuhan, selected using a computer-generated simple random sampling method, formed the Wuhan cohort. In the Wuhan cohort, illness onset in the first case was noted on December 24, 2019, and the first hospitalization occurred on January 5, 2020 (Figure 1A).\u003c/p\u003e\n\u003cp\u003eThere were 538 patients with COVID-19 who were consecutively admitted to 41 designated hospitals in Sichuan Province. The Sichuan cohort comprised 474 patients (Figure 1B), when 64 patients with inaccessible medical records were excluded. Epidemiological data indicated that the first cases of SARS-CoV-2 infection in the Sichuan cohort occurred in December 31, 2019, and the first case was admitted to the designated hospital on January 16, 2020 (Figure 1C). The daily Wuhan-related exposure cases with onset of COVID-19 in the Sichuan cohort peaked on January 23, 2020, and those without Wuhan-related exposure peaked on February 1, 2020 (Figure 2A and 2B). The median time from illness onset to admission in the Sichuan cohort was significantly shorter than that in the Wuhan cohort (5.0 [2.0, 9.0] vs. 10.0 [7.0, 15.0] days, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001). The Sichuan cohort had a lower proportion of patients with an exposure history than that in the Wuhan cohort (64.3% vs. 99.3%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001).\u003c/p\u003e\n\u003cp\u003eThe demographic and clinical characteristics of these patients are shown in Table 1 and S1. Patients in the Sichuan cohort were younger (44 [32.0, 54.0] vs. 58 [43.0, 67.0] yrs, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), there were fewer females (46.4% vs. 54.1%, \u003cem\u003eP\u003c/em\u003e=0.010), and included a higher number of current smokers (14.5% vs. 5.1%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001). Two patients (0.4%) in the Sichuan cohort and 13 (1.8%) in the Wuhan cohort were healthcare workers (\u003cem\u003eP\u003c/em\u003e=0.033). The commonest comorbidity in both cohorts was hypertension (23.6%), followed by diabetes (11.9%). The Wuhan cohort had more cases with comorbidities (51.2% vs. 43.8%, \u003cem\u003eP\u003c/em\u003e=0.012) as assessed by the Charlson Comorbidity Index[17] (CCI) (2.0 [2.0, 3] vs. 0 [0, 1.0], \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001). Fewer patients in the Sichuan cohort had a history of coronary heart disease (\u003cem\u003eP\u003c/em\u003e =0.004), liver disease (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), stroke (\u003cem\u003eP\u003c/em\u003e=0.026), hypertension (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), and malignancy (\u003cem\u003eP\u003c/em\u003e=0.012) than those in the Wuhan cohort.\u003c/p\u003e\n\u003cp\u003eFever was the commonest symptom and was present in 61.8% of patients in the Sichuan cohort or 65.1% of patients in the Wuhan cohort, but the difference was not significant (\u003cem\u003eP\u003c/em\u003e=0.246). The Sichuan cohort had a higher incidence of productive cough than the Wuhan cohort (\u003cem\u003eP\u003c/em\u003e=0.012). However, the Wuhan cohort seemed to have a higher symptomatic burden with regard to the lower respiratory tract, including shortness of breath (25.4% vs. 9.0%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), chest distress (23.8% vs. 9.0%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), wheeze (13.9% vs. 4.8%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), and general symptomatic burden, including fatigue (36.2% vs. 22.3%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), hemoptysis (3.0% vs. 1.1%, \u003cem\u003eP\u003c/em\u003e=0.028), altered consciousness (1.8% vs. 0.2%, \u003cem\u003eP\u003c/em\u003e=0.011), and diarrhea (12.1% vs. 6.3%, \u003cem\u003eP\u003c/em\u003e=0.001). In contrast, the Sichuan cohort was more likely to have upper respiratory symptoms, including pharyngalgia (13.9% vs. 7.5%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), rhinorrhea (5.0% vs. 1.4%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), nasal obstruction (3.4% vs. 1.1%, \u003cem\u003eP\u003c/em\u003e=0.007), and headache (10.1% vs. 4.6%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) (Figure 3A). Different severity distributions were observed between the two cohorts (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), as assessed by CURB-65 and MuLBSTA (both \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001). More than 75% of patients in both cohorts had mild or general disease, although the Sichuan cohort had a higher proportion of severe cases (17.0% vs. 8.4%) and the Wuhan cohort had more critically ill patients (13.6% vs. 6.3%). Chest CT radiographs in the Wuhan cohort were more likely to show bilateral lung involvement (\u003cem\u003eP\u003c/em\u003e=0.012) and consolidation (\u003cem\u003eP\u003c/em\u003e=0.006).\u003c/p\u003e\n\u003cp\u003eThere was no difference in white blood cell count, lymphocyte count, prothrombin time, albumin, alanine aminotransferase, aspartate aminotransferase, procalcitonin and interleukin 6 (IL-6) between the two cohorts. The Sichuan cohort had lower neutrophil count (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), platelet count (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), D-dimer levels (\u003cem\u003eP\u003c/em\u003e=0.001), and C-reactive protein levels (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) and higher levels of hemoglobin (\u003cem\u003eP\u003c/em\u003e=0.015), activated partial thromboplastin time (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), creatinine (\u003cem\u003eP\u003c/em\u003e=0.040), and creatine kinase (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) (Table 1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eT\u003c/strong\u003e\u003cstrong\u003ereatments\u003c/strong\u003e\u003cstrong\u003e and clinical outcomes\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA comparison of treatments and clinical outcomes between the two cohorts is shown in Table 2. Almost all patients received antiviral treatment in Sichuan (94.7%) or Wuhan (93.2%). Fewer patients in the Sichuan cohort received antibiotics (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), corticosteroids (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) and supplemental oxygen therapy (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001).\u003c/p\u003e\n\u003cp\u003eThe case fatality rate in the Sichuan cohort was obviously lower than that in the Wuhan cohort (0.6% vs. 8.3%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001). However, there was no significant difference in the proportion of patients receiving noninvasive mechanical ventilation or invasive mechanical ventilation between the two cohorts (5.7% vs. 5.9%, \u003cem\u003eP\u003c/em\u003e=0.872 and 1.7% vs. 1.4%, \u003cem\u003eP\u003c/em\u003e=0.701). With regard to the secondary outcomes, the proportion of patients who were admitted to the ICU in the Sichuan cohort was significantly lower than that in the Wuhan cohort (6.3% vs. 13.6%, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001). The time from illness onset to ICU admission and time from illness onset to discharge in the Sichuan cohort were shorter than that in the Wuhan cohort (7.0 [4.0, 10.5] vs. 11.5 [8.8, 24.3] days, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001 and 23.0 [18.0, 31.0] vs. 28.0 [18.0, 38.0] days, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001). The length of hospital stay in the Sichuan cohort was much longer than that in the Wuhan cohort (17.0 [12.0, 24.0] vs. 14.0 [9.0, 24.0] days, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001). In contrast, the Wuhan cohort had a significantly prolonged duration of SARS-CoV-2 shedding than that in the Sichuan cohort (19.0 [13.0, 28.0] vs. 14.0 [10.0, 19.0] days, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLogistic regression analyses\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMultivariable logistic regression models were used to explore the differences in clinical outcomes between the Sichuan and Wuhan cohorts (Table 3). The results showed that the Wuhan cohort had higher risk of death (aOR=7.64, 95% CI=[2.31, 25.27], \u003cem\u003eP\u003c/em\u003e=0.001), ICU admission (aOR=1.66, 95% CI=[1.05, 2.63], \u003cem\u003eP\u003c/em\u003e=0.031), delayed time from illness onset to hospital \u0026nbsp;(aOR=6.29, 95% CI=[4.70, 8.40], \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) and ICU admission (aOR=8.03, 95% CI=[1.74, 37.06], \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) admissions, prolonged duration of viral shedding after COVID-19 onset (aOR=1.64, 95% CI=[1.15, 2.33], \u003cem\u003eP\u003c/em\u003e=0.006), a decreased hospital stay (aOR=0.41, 95% CI=[0.32, 0.53], \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) after adjusting for age, sex, smoking status and the CCI. There was no difference in time from illness onset to discharge (aOR=0.99, 95% CI=[0.77, 1.28], \u003cem\u003eP\u003c/em\u003e=0.968) after adjusting for these confounders. When we additionally adjusted for time from illness onset to hospitalization, the risk of the Wuhan cohort was nearly unchanged; however, the Sichuan cohort had a lower risk for extended time from illness onset to discharge (aOR=0.46, 95% CI=[0.34, 0.63], \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001).\u003c/p\u003e\n\u003cp\u003eIn the overall study population of COVID-19 patients from the two cohorts, we constructed multivariable logistic regression models to detect the risk factors at admission for death, ICU admission, mechanical ventilation and duration of viral shedding after COVID-19 onset (Table S2). After adjusting for the cohort sites, sex, age, smoking status and the CCI, we found that white blood cells (\u0026gt;10\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L), neutrophils (\u0026gt;6.3\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L), lymphocytes (\u0026gt;1.0\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L), hemoglobin (\u0026lt;90 g/L), D-dimer (\u0026gt;0.5 mg/L), creatine kinase (\u0026gt;185 IU/L), hyper-sensitive troponin I (\u0026gt;0.04 ng/mL), alanine aminotransferase (\u0026gt;50 IU/L), aspartate aminotransferase (\u0026gt;40 IU/L), procalcitonin (\u0026gt;0.5 ng/mL) and delayed hospitalization were associated with death, ICU admission and mechanical ventilation. In addition, we found that time from illness onset to hospitalization was associated with prolonged duration of virus shedding (adjusted \u0026beta;=0.11, 95% CI= [0.03, 0.24], \u003cem\u003eP\u003c/em\u003e=0.009).\u003c/p\u003e\n\u003cp\u003eWe analyzed the relationship between the delay in hospitalization and elevated systemic inflammation and features of organ dysfunction. The time from illness onset to hospitalization was positively correlated with systemic inflammatory cells such as white blood cells (r=0.086, \u003cem\u003eP\u003c/em\u003e=0.004), neutrophils (r=0.089, \u003cem\u003eP\u003c/em\u003e=0.003), eosinophils (r=0.116, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), platelets (r=0.212, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), and inflammatory biomarkers, such as D-dimer (r=0.101, \u003cem\u003eP\u003c/em\u003e=0.004), procalcitonin (r=\u0026minus;0.093, \u003cem\u003eP\u003c/em\u003e=0.019), features of organ dysfunction, such as hemoglobin (r=\u0026minus;0.155, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), BUN (r=0.10, \u003cem\u003eP\u003c/em\u003e=0.002), creatine (r=\u0026minus;0.094, \u003cem\u003eP\u003c/em\u003e=0.003), albumin (r=\u0026minus;0.263, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001), and APTT (r=\u0026minus;0.247, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.001) (Table 4). After adjusting for age, the correlations of delay in hospitalization with BUN and D-dimer did not achieve statistical significance, which indicated that the delay in hospitalization was independent of age. We further analyzed the relationship between the delay in hospitalization and ICU admission with elevated systemic inflammation after adjusting for age, sex, smoking, and steroid use. In general, the relationship between the delay in hospitalization and elevated systemic inflammation did not change, which implied that these relationships were independent of age, sex, smoking, and steroid use.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubgroup analyses between Sichuan sub-cohorts with vs. without Wuhan-related exposure \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere was almost no difference in clinical characteristics and outcomes between the two sub-cohorts with and without Wuhan-related exposure in Sichuan. Detailed information is provided in Supplementary Data (Tables S3, S4 and S5).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSichuan sub-cohort with Wuhan-related exposure vs. Wuhan cohort\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe differences in the clinical characteristics and outcomes between the Sichuan sub-cohort with Wuhan-related exposure and Wuhan cohort were similar to the differences between the Sichuan and Wuhan cohorts. The results are described in detail in the Supplementary Data (Tables S6, S7 and S8).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eTo the best of our knowledge, there exists a paucity of information obtained from a comparative large-sample study on the differences in epidemiology, clinical characteristics and outcomes of patients with COVID-19 between the epicenter (Wuhan) and the peripheral areas of pandemic. This comparative study provides important insights. First, the outbreak and transmission of COVID-19 within the region of Sichuan as the peripheral epidemic area has been well contained within two months through the use of traditional public health outbreak response tactics. Second, the Sichuan cohort is characterized by a higher incidence of upper airway symptoms, whereas the Wuhan cohort was older, had fewer lower airway symptoms and comorbidities, and had elevated pivotal systemic inflammation indicative of organ dysfunction as well as worse clinical outcomes independent of sex, age, smoking and comorbidities. Third, the subgroup analysis indicated that, within the Sichuan cohort, the patients with Wuhan-related exposure had similar clinical features and outcomes to those with non-Wuhan-related exposure. Fourth, the Wuhan-related exposure patients in the Sichuan cohort had better clinical outcomes than those in the Wuhan cohort, although these two groups of patients had a similar Wuhan-related exposure history.\u003c/p\u003e\n\u003cp\u003eAs indicated in recently published studies[12], the COVID-19 patients in Wuhan, at the epicenter area of the epidemic, were older, had more co-existing conditions assessed by the CCI, had extended time from illness onset to hospitalization, and included more severely ill patients. However, the Sichuan cohort, as the peripheral area, had some characteristics features. First, there were fewer healthcare workers in the Sichuan cohort than in the Wuhan cohort, which could be at least partially explained by the insufficient implementation of precautions and the overwhelmed health system during the earlier stage of this outbreak in Wuhan. Second, intriguingly, there was a higher incidence of upper airway symptoms, rather than high incidence of lower airway symptoms in the Wuhan cohort at the epicenter epidemic, which was similar to the findings from exported cases in Singapore[18]. Accordingly, the exported patients from the epicenter were usually diagnosed with a \u0026ldquo;common cold\u0026rdquo; at the beginning of the COVID-19 outbreak. The different populations, the airway proliferation location, or the evolution of SARS-CoV-2 possibly could account for these differential symptoms[18-21]. Third, within the consecutively recruited cases in the Sichuan cohort as a well-defined population, the subgroup analyses indicated a higher proportion of males and older patients among the non-Wuhan-related exposure patients, which supported the theory of the propensity for SARS-CoV-2 infection in males and elders[9, 22, 23]. Recent studies from the USA and Italy have reported that a greater proportion of elderly and male COVID-19 patients would experience more critical illness[24, 25].\u003c/p\u003e\n\u003cp\u003eUntil now no antiviral treatment for COVID-19 has proven effective, and supportive care is the mainstay of treatment is. Compared with the Wuhan cohort, the use of antibiotics (i.e. cephalosporin and quinolones) and glucocorticoids in the Sichuan cohort decreased by 26.4% and 16.1%, respectively. These results could possibly be explained as follows. First, as indicated earlier, the expert panel drawn from the multidisciplinary team established by HCSP together developed and adjusted the treatment plan for severely or critically ill patients according to the interim guidance from the National Health Commission of China and the WHO across the 208 designated hospitals in Sichuan by using the 5G network every day. Accordingly, the use of systemic corticosteroids was strictly managed and they were not routinely administered for the treatment of COVID-19 patients. Second, the COVID-19 patients in the Wuhan cohort would actually be more severe or critically ill, which was supported by the increased use of supplemental oxygen in case of acute hypoxia. In addition, prone-position ventilation, physical rehabilitation and a variety of traditional Chinese medicines were used more often in Sichuan under the guidance of the expert panel; however, this aspect needs to be investigated further in randomized controlled trials[7, 8].\u003c/p\u003e\n\u003cp\u003eIn terms of clinical outcomes, several important findings were identified in this study. An epidemic outbreak provided an opportunity to obtain important information, some of which were associated with a limited window of opportunity. This study showed that there was a delay from illness onset to hospitalization in the Wuhan cohort, which might be an important risk factor for the progression of COVID-19. Multivariate regression analysis showed that the time from illness onset to hospitalization was significantly associated with mortality and ICU admission, which suggested some important implications with regard to the pathogenesis of SARS-CoV-2 and may provide insights into a unique window of opportunity for intervention[7]. Liang \u003cem\u003eet al\u003c/em\u003e.[12] recently found that Wuhan-related exposure patients have worse clinical outcomes compared with the non-Wuhan-related exposure cases; they attributed the attenuated disease to the onward transmission of SARS-CoV-2. In fact, this is paradoxical to the findings reported from Liang \u003cem\u003eet al\u003c/em\u003e.\u0026rsquo;s study[12] because the relationship between Wuhan-related exposure and prognosis disappeared after adjusting for confounders. Our study firstly found that COVID-19 patients in the Wuhan cohort had worse clinical outcomes including case fatality rate, ICU admission, and duration of virus shedding, independent of sex, age, smoking, comorbidities, and even time from illness onset to hospitalization. The severity of COVID-19 and the shortage of medical resources would partly account for these worse outcomes. For example, during an earlier stage of the outbreak, some patients would not have received sufficient oxygen support because of insufficient oxygen pressure.\u003c/p\u003e\n\u003cp\u003eThe duration of infectious virus replication is an important factor in assessing the risk of transmission and for guiding decisions on the isolation of patients; however, the duration of SARS-CoV-2 RNA detection has not been well explored. Our study found that the Wuhan cohort in the epicenter area had the prolonged virus shedding, which may contribute to the disease severity and clinical course[26, 27]. Furthermore, we found for the first time that the duration of virus shedding was independently associated with age and time from illness onset to hospitalization. Our findings are supported by those of other studies. Liu \u003cem\u003eet al\u003c/em\u003e.[28] found that the viral load in severe cases was higher than that of mild cases, which had early viral shedding. Wolfel \u003cem\u003eet al\u003c/em\u003e.[29] found that virus shedding in the upper airway, which is the location of mild COVID-19, was very high during the first week of symptoms, whereas shedding of viral RNA from sputum derived from the lower airway, which is the region of general to critical illness in COVID-19, outlasts the disappearance of symptoms. Xu \u003cem\u003eet al\u003c/em\u003e.[30] found that elderly patients had prolonged virial shedding, but the correlation of age with the duration of viral shedding disappeared after adjusting for confounders, although this might be partly attributed to the small sample size.\u003c/p\u003e\n\u003cp\u003eAs the pandemic evolves, mutations and natural selection of SARS-CoV-2 inevitably occur, although this virus a lower mutation rate than that of other RNA viruses[31]. The China National Center for Bioinformation aligned 77,801 genome sequences of SARS-CoV-2 that were detected globally and identified a total of 15,018 mutations[32]. Studies have shown that mutations play an important role in the virulence and infectivity of SARS-CoV-2, although no significant association was found between mutations and outcomes pertaining to hospitalization or death[33-35]. Thus, it is unclear whether the different clinical outcomes of patients with COVID-19 between the epicenter and peripheral areas affected by the pandemic are due to mutations in SARS-CoV-2.\u003c/p\u003e\n\u003cp\u003eThis large-sample comparative study provides informative insights into the differences in epidemiology, clinical characteristics and outcomes of patients with COVID-19 between the epicenter (Wuhan) and peripheral (Sichuan) areas of the pandemic. However, there are several limitations that need to be addressed. First, due to the retrospective study design, data generation was clinically driven, and not all laboratory data were available for all patients. Accordingly, the missing data for some patients may have biased the findings. Second, the Sichuan cohort, which\u0026nbsp; represented the peripheral area of the COVID-19 pandemic, was incomplete although consecutive patients accounting for 88.1% of total cases with COVID-19 were recruited from 41 designated hospitals in Sichuan. Third, we did not analyze the genetic diversity of virus strains and the evolutionary history, which might well explain the differences between the epicenter and peripheral areas affected by the pandemic.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eThis comparative study found that there were significant differences in the epidemiology, clinical characteristics, and outcomes of patients with COVID-19 between the epicenter and peripheral areas affected by the pandemic. The worse outcomes in the epicenter could be partly explained by the overwhelming of health systems and the delayed time from illness onset to hospitalization. This was associated with elevated systemic inflammation, organ dysfunction and prolonged duration of virus shedding, independent of sex, age, smoking and comorbidities. This has potential implications that are of clinical relevance in interventions for COVID-19. The data suggests that urgent or early supportive care would achieve improved clinical outcomes, leading to a lower death rate although no proven effective therapies currently exist. No differences were found in the epidemiology, clinical characteristics, and outcomes between the first generation and secondary generation of patients in the peripheral area of pandemic. Biological differences accounting for the differences between the Wuhan-related exposure patients in the Sichuan cohort and Wuhan cohort need to be further investigated.\u003c/p\u003e"},{"header":"List Of Abbreviations","content":"\u003cp\u003eaOR: adjusted odds ratio\u003c/p\u003e\n\u003cp\u003eCCI: Charlson comorbidity index\u003c/p\u003e\n\u003cp\u003eCI: confidence interval\u003c/p\u003e\n\u003cp\u003eCOVID-19: coronavirus disease 2019\u003c/p\u003e\n\u003cp\u003eHCSP: The Health Commission of Sichuan Province\u003c/p\u003e\n\u003cp\u003eISARIC: International Severe Acute Respiratory and Emerging Infection Consortium\u003c/p\u003e\n\u003cp\u003eOR: odds ratio\u003c/p\u003e\n\u003cp\u003eSARS-CoV-2: severe acute respiratory syndrome coronavirus 2\u003c/p\u003e\n\u003cp\u003eWHO: world health organization\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe Biological and Medical Ethics Committee of West China Hospital (approval number: 2020-304 and 2020-126) and the Ethic Committee of Renmin Hospital of Wuhan University (approval number: WDRY2020-K068) granted ethical approval for this study. Administrative permission to access the raw data was granted by administrators of each hospital. Written informed consent from each participant was waived for design of a retrospective study. The data used in this study was anonymised before its use.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was supported by the Sichuan Provincial Program for Diagnostic and Treatment of COVID-19 (No. 2020YFS002 and 2020YFS005), and the National Key Development Plan for Precision Medicine Research (2017YFC091004), and the National Natural Science Foundation of China (No. 81920108002). Funding sources played no role in the study design, data analysis, decision to publish, or preparation of the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor's contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGW, FML, DL, JSL, NX, JFL, ZAL, WML had roles in the study design, data analysis, data interpretation, and writing of the manuscript. YW, HC, PWT, TF, LT, HY, LW, MF, ZN, BW, ZFS, XLW, HJW, XT, MX, XYL, BL, CJ, JX, JS had roles in the collection, processing, cleaning, and interpretation of data. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe would like to thank all the patients who donate their data for this analysis and all medical staffs working in the front line for taking care of the patients. We show thanks to Dr. Xuan Zhang, PhD, Dr. Xin Zhang, MD, Dr. Ting Wang, MD, and Dr. Ji Wang, MD, for their statistical analyses and editing work. We are indebted to the coordination of Ms. Jun Hua Li from the Health Commission of Sichuan Province, and Mr. Nian Li and Ms. Bei Bai from West China Hospital, Sichuan University, who greatly facilitate the collection of patients\u0026rsquo; data.\u003c/p\u003e\n\u003cp\u003eWe appreciate the expert panel from multiple disciplines team as follows: (1) Respiratory and Critical Care Medicine: Zong An Liang, Feng Min Luo, Chun Tao Liu, Hong Fan, Dan Liu, He Yu at West China Hospital, Sichuan University, Yang Yang from Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital ,Song Ping Wang, Wen Jun Wang from Affiliated Hospital of Southwest Medical University, Xiao Ju Chen, Li Jiang at Affiliated Hospital of North Sichuan Medical College, Zhen Liang Xiao at General Hospital of Western War Zone, Qing Song Huang, Yan Dong at Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, De Hai Yu from the Second Traditional Chinese Medicine Hospital of Sichuan, Xiao Hui Zhang from Sichuan Integrative Medicine Hospital, Su Hua Ao from Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Yong Sheng Wang from The first People's Hospital of Chengdu, Guo Ping Li from The Third People's Hospital of Chengdu, Ya Lin Liu, Gui Hui Wu at Public Health Clinical Center of Chengdu, Wei Guo Xu from Mianyang Central Hospital, Zheng Guang He from Suining Central Hospital; (2) Nosocomial infection: Zhi Yong Zong, Wei Jia Yin at West China Hospital, Sichuan University, Jian Jun Deng at The Second West China Hospital, Sichuan University, Jia Yu Wu at Sichuan Provincial Peoples Hospital, Rong Li Wang, Jiao Xia at The affiliated hospital of Southwest Medical University, Zong Ying Jing at The TSC hospital of Southwest Medical University, Yong Fang Liu, Bi Feng Xu at The affiliated hospital of North Sichuan Medical College, Zhang Chen at The General Hospital of Western theater Command, Wen Sheng Zhang at Affiliated Hospital of Chengdu University of TCM, Hua Guo at Chengdu Third People`s Hospital, Ping Chen, Xiao Fei Duan at Public Health and Clinical Center of Chengdu, Chun Hua Ma at Mianyang 404 Hospital; (3) Radiology: Bin Song, Hong Li Bai, Jian Qun Yu at West China Hospital, Sichuan University, Jin Jiang at Sichuan Provincial Peoples Hospital, Jian Shu, Fu Gang Hang at The affiliated hospital of Southwest Medical University, Tian Wu Chen, Qiong Hui Zhao at The affiliated hospital of North Sichuan Medical College, Rui Jiang at The General Hospital of Western theater Command, Ming Guo Xie at Affiliated Hospital of Chengdu University of TCM, Bin Yang at The TSC hospital of Southwest Medical University, Na Zhang, Xin Wei Wang at Public Health and Clinical Center of Chengdu, Qi Yu Liu at Mianyang Central Hospital; (4) Department of Laboratory Medicine: Kang Mei, Xie Yi at West China Hospital, Sichuan University, Jiang Li, Yu Hua from Sichuan Provincial People\u0026rsquo;s Hospital ,Liu Jin Bo, Li Bao Lin from Affiliated Hospital of Southwest Medical University, Zhang Guo Yuan, Huang Yi Shan from Affiliated Hospital of North Sichuan Medical College, Hu Zong Hai, Dan Gang from the General Hospital of Western Theater Command, Xiong Da Qian from Chengdu University of Traditional Chinese Medicine, Guo Yong Can from Southwest Medical University of Traditional Chinese Medicine, Li Qing Feng, Cao Ling from the Public Health Clinical Center of Chengdu; (5) Diagnosis and Treatment of Infectious Diseases: Tang Hong, Feng Ping, Lv Xiao Ju, Bai Lang at West China Hospital, Sichuan University, Yang Xing Xiang from Sichuan Provincial People\u0026rsquo;s Hospital, Huang Yong Mao, Huang Fu Li from Affiliated Hospital of Southwest Medical University, Xiong Liang Shi, Liu Feng Jun from Affiliated Hospital of North Sichuan Medical College, Zhang Ling ,Zeng Yi Lan from the General Hospital of Western Theater Command, He Sheng Hua from the Public Health Clinical Center of Chengdu;(6) Critical Care Medicine: Yan Kang, Xiao Dong Jin, Zhong Wei Zhang at West China Hospital, Sichuan University, Xiao Bo Huang from Provincial People\u0026rsquo;s Hospital, Xian Ying Lei, Chang Xue Wu at the Affiliated Hospital of Southwest Medical University, Ying Ge, Da Qing Wang at the Affiliated Hospital of North Sichuan Medical College, Fu Xiang Li, Zhang Wang at the General Hospital of Western Theater Command, Pei Yang Gao from Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Xiao Bin Li from Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University, Yun Feng Chen from Chengdu Integrated Traditional Chinese Medicine \u0026amp; Western Medicine Hospital, Chuan Zhang from Chengdu Third People\u0026rsquo;s Hospital, Hong Chen, Hong De Chen, Ling Zhang at Chengdu Public Health Clinical Medical Center; (7) Emergency treatment: Jun Zeng, Ping Zhou, Xiao Mei Wang at Provincial People\u0026rsquo;s Hospital, Yu Cao from West China Hospital, Sichuan University, Wu Zhong, Ying Liu at the Affiliated Hospital of Southwest Medical University, Shi Ping Liu, Zhi Jiang at the Affiliated Hospital of North Sichuan Medical College, Gui Sen Xu from the General Hospital of Western Theater Command, Yun Lu, Xiao Yun Zhang at Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Zhi Hong Zhang from Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University, Yu Fei Hou from Chengdu Emergency Command Center, Wen Jun Li, Bo Leng at Chengdu Public Health Clinical Medical Center; (8) Traditional Chinese Medicine: Shao Hong Chen, Cheng Shi He,Xiao Yu Hu, Kun Yang at Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Gang Suo from Sichuan Provincial Orthopedics Hospital.\u003c/p\u003e\n\u003cp\u003eWe also show thanks to Li Yan A, Ling Chen, Jing Yu Cui, Ke Deng, Su Jun Deng, Xue Mei Fang, Min Feng, Xiao Min Fu, Yu Yu Han, Jia Xin Hou, Yue Hong Hu, Dan Huang, Qiao Yun Huang, Min Li, Ren Jiao Li, Xiao Qian Li, Yu Qi Li, Jun Zhe Liao, Ping Lin, Zhi Lin, Dan Liu, Jia Liu, Lei Liu, Sha Liu, Shi Yao Liu, Zhi Hao Liu, Ya Lan Luo, Zhi Wen Ma, Min Qi, Xing Yu Qiu, Fang Yu Shi, Tao Lin Qin, Xiao Ju Tang, Rui Tian, Xin Tian, Dan Wang, Ji Wang, Qin Wang, Ting Wang, Yi Wei Wang, Yu Wang, Jia Hao Wu, Wen Wen Wu, Lin Rui Xu, Zhuan Hua Yang, Dong Fan Ye, Yuan Ye, Ze Lin Yin, Yu Lai Yuan, Jing Xuan Zhang, Liang Liang Zhang, Xin Zhang, Ya Li Zhang, Yu Yang Zhang, Yu Chen Zhang, Li Chun Zhong, Qiao Zhou, Yu Yan Zhou, Wen Juan Zhu, Wen Jun Zhu, Ying Ying Zhu, En Qiang Chen, Ming Jin Dai, Hui Gao, Hong Bo Jia, Yang Li, Min Tao Lin, Qi Liu, Lu Lu, Ruo Ting Men, Zhi Ming Ni, Da Nan Pan, Yuan Ya Qin, Tian Rui Ren, Si Si Shen, Yan Jun Si, Jia Jia Song, Xing Bo Song, Li Yi Wang, Wen Xiu Wang, Yong Wang, Xi Zhan Weng, Qin Wu, Yu Jie Wu, Xian Xing, Rong Fang Yan, Zhi Qing Yan, Lan Yang, Le Tian Yang, Ying Ying Yang, Jia Yu Ye, Ling Zhang, Qi Zhang, Sheng Zhang, Ying Teng Zhang, Ying Ying Zhang, Yu Wei Zhang, Han Jiang Zeng for their dedication to data entry and verification.\u003c/p\u003e\n\u003cp\u003eWe also show thanks to hospitals who recruited the included cases as following: West China Hospital of Sichuan University, The Public Health Clinical Center of Chengdu, People\u0026rsquo;s hospital of Jianyang, Pidu District People\u0026rsquo;s Hospital of Chengdu, Zigong First People\u0026rsquo;s Hospital, Jintang County First People\u0026rsquo;s Hospital, People\u0026rsquo;s Hospital of Deyang City, Sichuan Mianyang 404 Hospital, The Third People\u0026rsquo;s Hospital of Guangyuan, The Fourth People\u0026rsquo;s Hospital of Panzhihua, Luzhou Infectious Diseases Hospital, Suining Central Hospital, The First People\u0026rsquo;s Hospital of Neijiang, Neijiang Second Municipal People\u0026rsquo;s Hospital, People\u0026rsquo;s Hospital of Leshan, Affiliated Hospital of North Sichuan Medical College, The Second People\u0026rsquo;s Hospital of Yibin, Linshui County Peoples\u0026rsquo;s Hospital of Guangan, Yuechi County Peoples\u0026rsquo;s Hospital, Guang\u0026rsquo;an People\u0026rsquo;s Hospital (West China-Guang\u0026rsquo;an Hospital, Sichuan University), People\u0026rsquo;s Hospital of Huaying, Dazhou Central Hospital, Bazhong Central Hospital, Third Branch of Yaan People\u0026rsquo;s Hospital (Hospital of Infectious Diseases), Meishan City People\u0026rsquo;s Hospital, The First People\u0026rsquo;s Hospital of Ziyang, The First People\u0026rsquo;s Hospital of Liangshan Yi Autonomous Prefecture, Ganluo County People\u0026rsquo;s Hospital of Liangshan Yi Autonomous Prefecture, People\u0026rsquo;s Hospital of Aba Tibetan and Qiang Autonomous Prefecture, Ganzi Tibetan Autonomous Prefecture People\u0026rsquo;s Hospital, Nanchong Central Hospital, Pengan County People\u0026rsquo;s Hospital, People\u0026rsquo;s Hospital of Langzhong, Nanbu County People\u0026rsquo;s Hospital, The Fifth People\u0026rsquo;s Hospital of Nanchong, Yilong County People\u0026rsquo;s Hospital, Yingshan County People\u0026rsquo;s Hospital, Pinchang County People\u0026rsquo;s Hospital, Tongjiang County People\u0026rsquo;s Hospital, Medical Center Hospital of Qionglai, Jiangyou Infectious Diseases Hospital.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eWenjie T, Xiang Z, Xuejun M, Wenling W, Peihua N, Wenbo X, George FG, Guizhen W: A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases \u0026mdash; Wuhan, China 2019\u0026minus;2020. China CDC Weekly 2020, 2(4):61-62.\u003c/li\u003e\n\u003cli\u003eHuang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020, 395(10223):497-506.\u003c/li\u003e\n\u003cli\u003eWang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y et al: Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA 2020.\u003c/li\u003e\n\u003cli\u003eChen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y et al: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020, 395(10223):507-513.\u003c/li\u003e\n\u003cli\u003eZeng Y, Li DJ, Zong ZY, Jiang Y, on behalf of Sichuan Medical Treatment Expert Group for Covid-19: The emergency prevention and control guidelines for Covid-19 in medical institutions of Sichuan province. In.: Sichuan Science and Technology Press; 2020.\u003c/li\u003e\n\u003cli\u003eBrooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, Rubin GJ: The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020, 395(10227):912-920.\u003c/li\u003e\n\u003cli\u003eFauci AS, Lane HC, Redfield RR: Covid-19 - Navigating the Uncharted. N Engl J Med 2020, 382(13):1268-1269.\u003c/li\u003e\n\u003cli\u003eSanders JM, Monogue ML, Jodlowski TZ, Cutrell JB: Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. JAMA 2020.\u003c/li\u003e\n\u003cli\u003eCai Q, Huang D, Ou P, Yu H, Zhu Z, Xia Z, Su Y, Ma Z, Zhang Y, Li Z et al: COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy 2020.\u003c/li\u003e\n\u003cli\u003eXu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, Li SB, Wang HY, Zhang S, Gao HN et al: Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ 2020, 368:m606.\u003c/li\u003e\n\u003cli\u003eTian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, Chen H, Wang D, Liu N, Liu D et al: Characteristics of COVID-19 infection in Beijing. J Infect 2020, 80(4):401-406.\u003c/li\u003e\n\u003cli\u003eLiang WH, Guan WJ, Li CC, Li YM, Liang HR, Zhao Y, Liu XQ, Sang L, Chen RC, Tang CL et al: Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): A Nationwide Analysis of China. Eur Respir J 2020.\u003c/li\u003e\n\u003cli\u003eWHO. Novel Coronavirus\u0026ndash;China. 2020. https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/2020. Accessed May 8 2020.\u003c/li\u003e\n\u003cli\u003eWei JF, Huang FY, Xiong TY, Liu Q, Chen H, Wang H, Huang H, Luo YC, Zhou X, Liu ZY et al: Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis. Heart 2020, 106(15):1154-1159.\u003c/li\u003e\n\u003cli\u003eXiong W, Mu J, Guo J, Lu L, Liu D, Luo J, Li N, Liu J, Yang D, Gao H et al: New onset neurologic events in people with COVID-19 infection in three regions in China. Neurology 2020.\u003c/li\u003e\n\u003cli\u003eXiong TY, Huang FY, Liu Q, Peng Y, Xu YN, Wei JF, Li N, Bai B, Li JH, Prendergast B et al: Hypertension is a risk factor for adverse outcomes in patients with coronavirus disease 2019: a cohort study. Ann Med 2020:1-20.\u003c/li\u003e\n\u003cli\u003eCharlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987, 40(5):373-383.\u003c/li\u003e\n\u003cli\u003eYoung BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM et al: Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA 2020.\u003c/li\u003e\n\u003cli\u003eLi X, Wang W, Zhao X, Zai J, Zhao Q, Li Y, Chaillon A: Transmission dynamics and evolutionary history of 2019-nCoV. J Med Virol 2020, 92(5):501-511.\u003c/li\u003e\n\u003cli\u003eZhang J, Litvinova M, Wang W, Wang Y, Deng X, Chen X, Li M, Zheng W, Yi L, Chen X et al: Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study. Lancet Infect Dis 2020.\u003c/li\u003e\n\u003cli\u003eRubens JH, Karakousis PC, Jain SK: Stability and Viability of SARS-CoV-2. N Engl J Med 2020, 382.\u003c/li\u003e\n\u003cli\u003eLiu Y, Mao B, Liang S, Yang JW, Lu HW, Chai YH, Wang L, Zhang L, Li QH, Zhao L et al: Association between ages and clinical characteristics and outcomes of coronavirus disease 2019. Eur Respir J 2020.\u003c/li\u003e\n\u003cli\u003eZhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X et al: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020, 395(10229):1054-1062.\u003c/li\u003e\n\u003cli\u003eRichardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, and the Northwell C-RC, Barnaby DP, Becker LB, Chelico JD et al: Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA 2020.\u003c/li\u003e\n\u003cli\u003eGrasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R et al: Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA 2020.\u003c/li\u003e\n\u003cli\u003eLiu Y, Yan LM, Wan L, Xiang TX, Le A, Liu JM, Peiris M, Poon LLM, Zhang W: Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis 2020.\u003c/li\u003e\n\u003cli\u003eZhou B, She J, Wang Y, Ma X: The duration of viral shedding of discharged patients with severe COVID-19. Clin Infect Dis 2020.\u003c/li\u003e\n\u003cli\u003eLiu Y, Eggo RM, Kucharski AJ: Secondary attack rate and superspreading events for SARS-CoV-2. Lancet 2020, 395(10227):e47.\u003c/li\u003e\n\u003cli\u003eWolfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Muller MA, Niemeyer D, Jones TC, Vollmar P, Rothe C et al: Virological assessment of hospitalized patients with COVID-2019. Nature 2020.\u003c/li\u003e\n\u003cli\u003eXu K, Chen Y, Yuan J, Yi P, Ding C, Wu W, Li Y, Ni Q, Zou R, Li X et al: Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clin Infect Dis 2020.\u003c/li\u003e\n\u003cli\u003eZhao Z, Sokhansanj BA, Malhotra C, Zheng K, Rosen GL: Genetic grouping of SARS-CoV-2 coronavirus sequences using informative subtype markers for pandemic spread visualization. PLoS Comput Biol 2020, 16(9):e1008269.\u003c/li\u003e\n\u003cli\u003eHu B, Guo H, Zhou P, Shi ZL: Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol 2020.\u003c/li\u003e\n\u003cli\u003eChen J, Wang R, Wang M, Wei GW: Mutations Strengthened SARS-CoV-2 Infectivity. J Mol Biol 2020, 432(19):5212-5226.\u003c/li\u003e\n\u003cli\u003eKorber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B et al: Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell 2020, 182(4):812-827 e819.\u003c/li\u003e\n\u003cli\u003eNakamichi K, Shen JZ, Lee CS, Lee AY, Roberts EA, Simonson PD, Roychoudhury P, Andriesen JG, Randhawa AK, Mathias PC et al: Outcomes associated with SARS-CoV-2 viral clades in COVID-19. medRxiv 2020.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px; line-height: 200%; font-family: Calibri, sans-serif;\"\u003eTable 1.\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDemographics and clinical characteristics of patients in the Sichuan and Wuhan cohorts\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 5.0e+2pt;border: none;margin-left:-35.95pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eVariable\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eSichuan cohort\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eWuhan cohort\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026chi;\u003csup\u003e2\u003c/sup\u003e/Z\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003eP\u0026nbsp;\u003c/em\u003evalue\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003en\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1184\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e474\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e710\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eFemale, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e604 (51.0)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e220 (46.4)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e384 (54.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6.693\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.010\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 14.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAge, years (Median [IQR])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 14.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e50.50(37.00,64.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 14.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e44.00(32.00,54.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 14.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e58.00(43.00,67.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 14.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e12.054\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 14.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 3.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTravel in Wuhan/residence in Wuhan/no exposure history, n\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e141/869/174\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e128/177/169\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e13/692/5\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e527.493\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 15.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eHealth care workers, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e15 (1.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (0.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e13 (1.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4.532\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.033\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 13.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCurrent/ ever/ never smoking, n\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e96/42/892\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e67/18/376\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e29/24/516\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e26.843\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAny comorbidity\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e574 (48.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e208 (43.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e366 (51.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6.258\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.012\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCharlson Comorbidity Index\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.0 (0-2.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0-1.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (2.0-3.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e-9.190\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eDisease severity status, n \u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e97.524\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 22.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMild/general/severe/critical\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e194/725/141/127\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e28/337/81/30\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e166/388/60/97\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCURB-65 score, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 12.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0-1/2/3-5\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e837/68/20\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e369/12/2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e468/56/18\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e26.430\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 13.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMuLBSTA score (Median [IQR])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7.00(5.00,9.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.00(5.00,9.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7.00(5.00,9.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.96 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eLaboratory findings, Median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 12.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eWhite blood cell count, \u0026times;10⁹\u0026nbsp;/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.45(4.22,7.07)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.37(4.18,5.37)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.58(4.22,7.28)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.570\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.088\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eNeutrophil count, \u0026times;10⁹\u0026nbsp;/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.45(2.50,4.99)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.45(2.53,4.73)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.45(2.47,5.26)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2.723\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eLymphocyte count, \u0026times;10⁹\u0026nbsp;/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.18(0.83,1.63)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.18(0.81,1.60)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.18(0.84,1.64)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.074\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.157\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eEosinophil count, \u0026times;10⁹\u0026nbsp;/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.30(0.00,1.30)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.20(0.01,0.80)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.50(0.0,1.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.751\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 15.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eHemoglobin, g/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e131.00(119.00,144.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e137.00(126.00,151.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e127.00(117.00,137.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e8.049\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.015\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 22.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePlatelet count, \u0026times;10⁹\u0026nbsp;/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e197.00(148.00,262.50)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e175.00(137.00,230.50)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e215.00(165.00,281.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7.909\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 22.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eActivated partial thromboplastin time, s\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e28.50(25.90,32.20)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e30.90(27.70,34.90)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e27.40(25.20,29.90)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e10.129\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 12.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eProthrombin time, s\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e12.20(11.50,13.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e12.60(11.70,13.30)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e12.00(11.33,12.70)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2.052\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 12.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.115\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eD-dimer, mg/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.56(0.29,1.59)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.50(0.22,1.17)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.63(0.33,1.79)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.194\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 4.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAlbumin, g/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 4.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e39.70(35.50,43.30)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 4.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e43.00(39.60,45.70)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 4.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e37.70(34.00,40.80)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 4.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e11.556\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 4.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.128\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCreatinine, \u0026mu;mol/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e63.00(51.00,76.15)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e65.20(53.00,77.33)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e62.00(50.70,75.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2.051\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.040\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCreatine kinase, U/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e62.70(41.00,106.25)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e71.00(50.00,122.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e56.00(34.40,99.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.181\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAlanine aminotransferase, U/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e23.55(16.00,39.05)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e24.00(16.00,39.90)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e23.00(15.48,39.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.433\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 16.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.665\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAspartate aminotransferase, U/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e25.00(19.67,35.73)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e25.60(20.00,35.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e25.00(19.00,36.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.459\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.647\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 9.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eC-reactive protein, mg/L\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e19.95(6.80,53.92)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e10.16(2.67,24.72)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e28.45(8.70,65.20)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6.066\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 9.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 13.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eProcalcitonin, ng/mL\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.05(0.04,0.12)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.06(0.04,0.17)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.05(0.03,0.11)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2.06\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.039\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eHypersensitive troponin I, pg/ml\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.01(0.01,0.01)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.01(0.01,0.01)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.02(0.01,0.05)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.615\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 7.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eChest CT, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 7.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 7.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 7.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 7.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 7.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eBilateral lungs involvement\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e741 (93.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e328 (90.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e413 (95.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6.363\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 23pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.012\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eConsolidation\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e180 (19.6)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e73 (16.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e107 (23.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7.533\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.006\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eGround-glass opacity\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e666 (71.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e328 (71.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e338 (71.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.042\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.837\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 10.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eLinear opacity\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e257 (27.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e112 (24.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e145 (31.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.200\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 10.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.023\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 127.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 13.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-indent:10.0pt;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePleural effusion\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e49 (5.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.2pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e19 (4.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e30 (6.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.7pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2.559\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 13.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.110\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:200%;color:black;text-align:justify;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eCT, computed tomography\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:200%;color:black;text-align:justify;'\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:200%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTable 2. Treatments and outcomes of the patients in the Sichuan and Wuhan cohorts\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.7e+2pt;border: none;margin-left:-14.7pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eVariable\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eSichuan cohort\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eWuhan cohort\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026chi;\u003csup\u003e2\u003c/sup\u003e/Z\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003eP\u003c/em\u003e value\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003en\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1184\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e474\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e710\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eTreatments, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eAntiviral treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1110 (93.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e448 (94.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e662 (93.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.067\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.302\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eAntibiotics\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e698 (59.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e204 (43.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e494 (69.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e82.734\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eAntifungal\u0026nbsp;treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e35 (3.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e15 (3.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e20 (2.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.120\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.729\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 3.45pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eCorticosteroids\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e272 (23.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e63 (13.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e209 (29.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:3.45pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41.872\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 3.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eIntravenous immunoglobin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e9 (0.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (0.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-align:justify;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6 (0.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;text-align:justify;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.170\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.680\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: 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style=\"font-family: Calibri, sans-serif;\"\u003e273 (57.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e518 (731)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e30.175\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eProne-position ventilation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e30 (2.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid 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style=\"font-family: Calibri, sans-serif;\"\u003e3 (0.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (0.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (0.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.000*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eRenal replacement\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e9 (0.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (1.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4 (0.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.497*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eBlood transfusion\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e165 (14.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e30 (6.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e135 (19.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e38.587\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eNutrition support\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e131 (11.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e52 (11.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e79 (11.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.014\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.906\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eTCM\u0026nbsp;treatments\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e912 (77.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e418 (88.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e494 (69.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e55.620\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ePhysiotherapy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e29 (2.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e24 (5.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (0.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e22.605\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eOutcomes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eDeath, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e62 (5.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (0.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e59 (8.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e33.758\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eICU admission, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e127 (10.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e30 (6.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e97 (13.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e15.961\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eNoninvasive mechanical ventilation, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e69 (5.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e27 (5.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e42 (5.9)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.025\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.875\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eInvasive mechanical ventilation, n (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e18 (1.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e8 (1.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e10 (1.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:none;border-left:none;border-bottom: solid black 1.0pt;border-right:solid black 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:11.05pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.148\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.700\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eTime from illness onset to hospitalization, days\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e8.00(4.00,13.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.00(2.00,9.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e10.00(7.00,15.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e13.626\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eHospital stay, days\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e16.00 (9.00,24.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e17.00 (12.00,24.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e14.00(9.00, 24.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e-2.726\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 24.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eTime from illness onset to ICU admission, days\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 24.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e9.00(6.00,17.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 24.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7.00(4.00,10.50)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 24.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e11.50(8.75,24.25)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 24.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.192\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 24.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 31.9pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eTime from hospitalization to ICU admission, days\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 31.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.00(0.00,9.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 31.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4.00(0.00,9.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 31.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.00(0.00,10.50)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 31.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.415\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 31.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.678\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 26.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eTime from illness onset to discharge, days\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 26.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e26.00(18.00,35.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 26.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e23.00(18.00,31.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 26.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e28.00(18.00,38.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 26.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.693\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 26.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 20.2pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eTime from illness onset to death, days\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 20.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e16.50(13.00,21.75)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 20.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e13.00 (11, -)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 20.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e17.00 (13.00,23.50)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 20.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.240\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 20.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.235\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 27.95pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eTime from hospital admission to death, days\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 27.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5.00(3.00,7.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 27.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e10.00(6.00,-)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 27.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4.00(3.00,7.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 27.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1.427\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 27.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0.153\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134.75pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin-right:0in;margin-left:0in;font-size:16px;font-family:Helvetica;margin:0in;text-indent:10.0pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eDuration of viral shedding, days\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e14.00(9.00，22.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e13.00(8.00,18.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e17.00(11.00,27.00)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6.665\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"width: 6.5in;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e* Fisher\u0026apos;s exact test.\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eECMO, extracorporeal membrane oxygenation; TCM, traditional Chinese medicine.\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:200%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:200%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTable 3. Risk of adverse outcomes in Wuhan cohort in reference to the Sichuan cohort\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;line-height:115%;font-size:15px;font-family:\"Calibri\",sans-serif;color:black;'\u003e\n \u003ctable style=\"width:593.6pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 270.1pt;border: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:200%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eOutcomes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 158.55pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eUnadjusted\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 164.95pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAdjusted \u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eOR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e95%CI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 200%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eOR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e95%CI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 200%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDeath\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e14.286\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4.444- 45.455\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 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style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eNon-invasive mechanical ventilation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.044\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.063\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTracheotomy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.668\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.166-2.681-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.569\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.225\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.050-1.015\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.052\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTime from illness onset hosp\u003c/span\u003eitalization\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;(\u0026gt;5 days)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e6.849\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e5.208-9.009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e6.289\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4.695-8.403\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eHospital stay (\u0026gt;17 days)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.481\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.380-0.609\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.411\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.316-0.533\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTime from illness onset to ICU admission (\u0026gt;7 days)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e6.364\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.836-22.061\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.027\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e8.030\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.740-37.057\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTime from illness onset to discharge (\u0026gt;23 days)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.180\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.935-1.489\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.163\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.995\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.772-1.281\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.968\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTime from illness onset to death (\u0026gt;10 days)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4.706\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.399-55.447\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.218\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4.731\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.314-71.265\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.261\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTime from hospitali\u003c/span\u003ezation\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;to ICU admission (\u0026gt;4 days)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.857\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.243-3.024\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.811\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.665\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.122-3.620\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.637\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTime from hospital admission to death (\u0026gt;10 days)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.426\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.035-5.161\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.502\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.155\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.007-3.694\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.249\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 270.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDuration of viral shedding (\u0026gt; 13 days)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.881\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.363-2.597\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.7in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.640\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.153-2.333\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.006\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 593.45pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003csup\u003e\u003cspan style=\"line-height: 200%;\"\u003ea\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"line-height: 200%;\"\u003eAdjusted for s\u003c/span\u003eex\u003cspan style=\"line-height: 200%;\"\u003e, age, smoking and Charlson Comorbidity Index.\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Times New Roman\",serif;margin:0in;color:black;line-height:200%;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eICU, intensive care unit; CI, confidence interval; OR, odds ratio\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:200%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:200%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003eTable 4.\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e\u0026nbsp;Correlation of time from illness onset to hospitalization with systemic inflammation and features of organ dysfunction\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 5.9e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:161.75pt;border:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eVariables\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:117.0pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:center;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eModel 1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:103.5pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:center;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eModel 2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 99pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:center;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eModel 3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 103.5pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:center;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eModel 4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003er\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003er\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003er\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003er\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.75pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eWhite blood cell count, \u0026times;10⁹/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.086\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.004\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.081\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.007\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.082\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.007\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.080\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.008\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.75pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eNeutrophil count, \u0026times;10⁹/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.089\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.061\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.044\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.064\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.035\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.061\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.046\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.75pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eLymphocyte count, \u0026times;10⁹/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.026\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.391\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.027\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.380\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.025\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.414\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.032\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.293\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.75pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eEosinophil count, \u0026times;10⁹/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.116\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.119\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.118\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.127\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.75pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eHemoglobin, g/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.155\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.100\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.104\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.103\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.75pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ePlatelet count, \u0026times;10⁹ /L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.212\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.225\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.223\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.225\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.75pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eBUN, mmol/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd 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style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.210\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.047\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 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150%;\"\u003e0.046\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.182\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.75pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eC-reactive protein, mg/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.051\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.021\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.619\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: 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15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.019\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.123\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n 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150%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.75pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eIL-6, pg/mL\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp 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150%;\"\u003e0.407\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.5pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.155\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.171\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.144\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.211\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026minus;0.144\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;line-height:150%;color:black;text-align:right;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.215\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:normal;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:normal;color:black;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"background: white;\"\u003eModel 1: Unadjusted; Model 2: Adjusted for age; Model 3: Adjusted for age, sex, smoking; Model 4: Adjusted for age, sex, smoking, and use steroid use\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:15px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:10.0pt;line-height:normal;color:black;'\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif; background: white;\"\u003eAPTT, activated partial thromboplastin time; PT, prothrombin time; BUN, blood urea nitrogen\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"COVID-19, case fatality, epicenter, peripheral area, pandemic, comparative analysis","lastPublishedDoi":"10.21203/rs.3.rs-52333/v3","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-52333/v3","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e: There is limited information on the difference in epidemiology, clinical characteristics and outcomes of the initial outbreak of the coronavirus disease (COVID-19) in Wuhan (the epicenter) and Sichuan (the peripheral area) in the early phase of the COVID-19 pandemic. This study was conducted to investigate the differences in the epidemiological and clinical characteristics of patients with COVID-19 between the epicenter and peripheral areas of pandemic and thereby generate information that would be potentially helpful in formulating clinical practice recommendations to tackle the COVID-19 pandemic.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: The Sichuan \u0026amp; Wuhan Collaboration Research Group for COVID-19 established two retrospective cohorts that separately reflect the epicenter and peripheral area during the early pandemic. The epidemiology, clinical characteristics and outcomes of patients in the two groups were compared. Multivariate regression analyses were used to estimate the adjusted odds ratios (aOR) with regard to the outcomes.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: The Wuhan (epicenter) cohort included 710 randomly selected patients, and the peripheral (Sichuan) cohort included 474 consecutive patients. A higher proportion of patients from the periphery had upper airway symptoms, whereas a lower proportion of patients in the epicenter had lower airway symptoms and comorbidities. Patients in the epicenter had a higher risk of death (aOR=7.64), intensive care unit (ICU) admission (aOR=1.66), delayed time from illness onset to hospital and ICU admission (aOR=6.29 and aOR=8.03, respectively), and prolonged duration of viral shedding (aOR=1.64). \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e: The worse outcomes in the epicenter could be explained by the prolonged time from illness onset to hospital and ICU admission. This could potentially have been associated with elevated systemic inflammation secondary to organ dysfunction and prolonged duration of virus shedding independent of age and comorbidities. Thus, early supportive care could achieve better clinical outcomes.\u0026nbsp;\u003c/p\u003e\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","manuscriptTitle":"Differences in the clinical characteristics and outcomes of COVID-19 patients in the epicenter and peripheral areas of the pandemic from China: a retrospective, large-sample, comparative analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":3,"date":"2021-01-04 21:25:38","doi":"10.21203/rs.3.rs-52333/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"checksComplete","content":"","date":"2020-12-19T13:55:20+00:00","index":"","fulltext":""},{"type":"decision","content":"Accept","date":"2020-12-18T00:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":"","date":"2020-12-14 00:00:00","doi":"","editorialEvents":[{"type":"editorAssigned","content":"","date":"2020-12-14T00:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-12-13T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-12-13T23:00:00+00:00","index":"","fulltext":""},{"type":"notPreprinted","content":""}],"status":"timeline","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":"","date":"2020-12-10 00:00:00","doi":"","editorialEvents":[{"type":"decision","content":"Minor revision","date":"2020-12-10T00:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-12-01T00:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-11-30T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-11-30T23:00:00+00:00","index":"","fulltext":""},{"type":"notPreprinted","content":""}],"status":"timeline","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2020-11-09 14:20:51","doi":"10.21203/rs.3.rs-52333/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-11-17T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-11-13T00:00:00+00:00","index":3,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-11-13T00:00:00+00:00","index":3,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nThe authors have incorporated reviewer comments to their manuscript as requested.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"editorInvitedReview","content":"","date":"2020-11-12T00:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nThanks for revising the manuscript. The paper is in much better shape and is a smooth read. Please see attachment for minor suggestions.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **'I declare that I have no competing interests'**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **No**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-11-11T00:00:00+00:00","index":2,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-11-10T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-11-10T00:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-11-10T00:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nPlease condense or remove table 4 it is too cumbersome. The essential information can be included in the text or body of the paper.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"editorAssigned","content":"","date":"2020-11-02T00:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-11-01T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-11-01T23:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-08-20 15:38:03","doi":"10.21203/rs.3.rs-52333/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2020-09-19T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-18T12:00:00+00:00","index":3,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nThe authors present an interesting comparison of two COVID-19 epidemic settings: the epicenter versus a peripheral area. These settings appear to differ as to the severity of patient presentation and final outcome. Possible explanations for the observed differences are also presented. In all, the manuscript is well written and the data provided are clinically relevant.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"editorInvitedReview","content":"","date":"2020-09-16T12:00:00+00:00","index":2,"fulltext":"Recommendation: Major revisions required\nForm responses:\n---\n\nComments to Author:\n---\n\nI am not sure what \"head-to-head\" comparison implies in the context of this paper and would suggest omitting head-to-head.\nThe English is non-standard, and it makes it difficult and slow to read. In one place, I think authors end up saying exactly the opposite of what I think they intended, based on the context. The sequence of tenses is incorrect. It needs a good editing by a native speaker of English who also understands the science. They have put a tremendous amount of work into it, and it shows, but standard English usage is very idiosyncratic and hard for others to manage. Because it is hard to decode, it is a very slow read, which makes it seem very wordy. In my opinion much of that would resolve if the English were improved.\nLess gravel, fewer pebbles, or fewer patients or fewer people. If you count it use fewer. If you weigh or measure it, use less.\nIt seems critical to the paper that authors age stratify the groups, at least to the extent of comparing elders with elders. I hope the peripheral groups will be large enough to compare when stratified, especially after divided into Wuhan-related and no history of Wuhan relationship. How much of the improved outcome of the peripheral group is due to their being younger? In the body of the paper, they comment on the differences in presentation of the epicenter and peripheral groups, but they do not look at age vs. presentation.\nIt would be very important to include at least a short discussion of possible genetic changes in the virus, which I am sure has been determined in China, even if the locations and timing fail to correspond exactly to their choices of groups and locations. They are very temporally constrained, so there may be little likelihood that the virus changed. It may be more likely that they realized that less sick persons could still have COVID, so the differing nature of the two groups may reflect a growing knowledge of disease presentation, so that patients who were less sick were not dismissed as having a cold.\n. There is one critically important sentence that I cannot fix, because I do not fully understand it. In the abstract it is not clear how the \"random\" selection in Wuhan was performed. The link between the delay in hospitalization and ICU admission and the elevated systemic inflammation needs to be clarified. How is systemic inflammation defined? Did early supportive care decrease the inflammatory syndrome? What did hospitalization do to prevent or ameliorate the inflammatory syndrome? Did the usage of steroids or anticoagulants differ? How do these effects relate to the age of the patients? Do older patients, and/or patients with co-morbidities have prolonged virus shedding compared to younger persons? Could the differences be attributed solely to age, to hypertension, or to diabetes? Aside from improving the word usage, grammar, and sentence structure the authors need to provide information about selection and stratification. Once they recognized that they had a major new disease in Wuhan, did they admit less-symptomatic persons in Sichuan? The end date of the enrollment in the epicenter cohort is not clear. Are the sub-divided peripheral cohorts large enough to allow significant comparisons between age- and comorbidity-stratified groups?\nI edited a section of the abstract to the best of my ability, to indicate the infelicities. See below;\nAbstract\nBackground: There has been little information on the differences in the epidemiology, clinical characteristics of symptomatic patients, and outcomes between the initial outbreak of COVID-19 in Wuhan (the epicenter) and Sichuan (the peripheral area) early in the COVID-19 pandemic.\nMethods: The Sichuan \u0026 Wuhan collaborative research group for Covid-19 established two retrospective cohorts reflecting the epicenter and the peripheral areas during the early pandemic. Epidemiology, clinical characteristics, and outcomes of the patients in the two groups were compared. Multivariate regression analyses were performed to estimate adjusted odds ratios associated with various outcomes.\nResults: The Wuhan (epicenter) cohort included 710 randomly selected patients. The peripheral (Sichuan) cohort included 410 consecutive patients. Patients from the periphery had more upper airway symptoms while those in the epicenter had more lower respiratory tract symptoms and comorbidities. Patients in the epicenter had higher risk of death (aOR=7.64), ICU admission (aOR=1.66), longer delay from illness onset to hospital and ICU admissions (aOR=6.29 and 8.03 respectively) and prolonged duration of viral shedding (aOR=1.64).\n\nConclusions: Our results suggest that worse outcomes in the epicenter could be explained by prolonged time from illness onset to hospital and ICU admission, …I cannot edit the rest of this sentence, because I do not fully understand it. \n…Our results imply that early supportive care would lead to better clinical outcomes.\n(or does it imply that people would do better if they are younger or less sick to begin with.) (How would the situation be different if, instead of randomly selecting people in the epicenter, they age-matched the cohorts?)\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **'I declare that I have no competing interests'**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **No**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-15T12:00:00+00:00","index":3,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-09-14T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-03T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nThis is generally a good study but has needs better flow. This means that the wording needs to flow better and not be abrupt as below. This shows a good contrast between the epicenter and periphery. It is also good to note that Healthcare Workers in the periphery were less affected. Persons in other countries can find this information useful.\n\nAbstract\n\n\nUpon March 12, 2020, Wuhan cohort consisted of 710 patients using random\nsampling, and 474 consecutive cases constituted Sichuan cohort. - The wording need simple changing\n\n\nBackground\n\nthe existed investigations of patients between\n99 epicenter and peripheral areas of pandemic were insufficient. - the existed should be rephrased.\n\nMethods\n\nHere, we performed a head-to-head comparative study to analyze\n101 epidemiological and clinical characteristics between the epicenter and peripheral areas\n102 of pandemic based on all consecutively recruited Covid-19 patients in Sichuan and\n103 random sampling patients from two designated hospitals in Wuhan, which would\n104 possibly account for these differential clinical outcomes between these two regions.- too long, break into 2 sentences.\n\nSince the outbreak of Covid-19 in Wuhan as the epicenter of pandemic, the\n110 government of Sichuan province has implemented strict measures to struggle against\n111 Covid-19. The Health Commission of Sichuan Province (HCSP) focused on\n112 traditional public health outbreak response tactics including isolation, quarantine,\n113 social distancing, and community containment as indicated by National Health\n114 Commission of China. All medical resources were totally allocated by HCSP to\n115 maintain efficient use. We established the expert panel from multiple disciplines team\n116 consisting of 125 physicians led by Dr. Wei Min Li and Dr. Zong An Liang as the\n117 corresponding authors of this study on Jan 15, 2020, and soon released the emergency\n118 prevention and control guidelines for Covid-19 in medical institutions of Sichuan\n119 province[9]. Furthermore, we also funded two additionally important expert panels\n120 with psychological counseling[10] and traditional Chinese medicine as a\n121 complementary and alternative medicine[11, 12]. Severe or critically ill patients\n122 would have consultations with the expert panel team by using 5G network technique\n123 whenever necessary at 16: 30 in the afternoon daily. There were 208 designated\n124 hospitals across Sichuan province, which were generally distributed in every city that\n125 would be available for SARS-CoV-2 suspected or confirmed individuals.\n126 Fever clinics were created to exclusively screen patients with suspected\n127 SARS-CoV-2 infection as indicated in the supplementary data. - Tbis should be removed from methods and put in background\n\n\n\nThe primary outcomes included death or the use of mechanical ventilation. - Primary outcome should be death or admission to ICU for Mechanical Ventilation or Ward if Ventilation is not done in ICU to overwhelming numbers\n\nThe aim of our study is to report the difference of epidemiological, clinical\n169 characteristics and outcomes of Covid-19 patients in peripheral and epicenter areas of\n170 pandemic.- in the wrong place, should be at Beginning of the section. There should be a short description of the Statistics still.\n\nDiscussion\n. First, the outbreak and transmission of Covid-19 within the\n290 region of Sichuan as the peripheral epidemic area has well been of containment within\n291 no more than two months using traditional public health outbreak response tactics. - has well been of containment could be rephrased\n\nTables\n\nCan tables 1 \u0026 2 be condensed? This will make reading easier.\n\nGraphs\n\nCheck back the graphs. Some need labeling\n\nSupplementary Data like S1, 4 and 5 can be condensed and use in the publication as supplemtary data ( S) of course.\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewersInvited","content":"","date":"2020-08-31T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-08-31T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2020-08-03T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-08-02T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-08-02T12:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"","date":"2020-07-30T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"bea0bc7c-ea2d-40ba-b210-bd231b68ed99","owner":[],"postedDate":"January 4th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":1550704,"name":"Infectious Diseases"}],"tags":[],"updatedAt":"2021-02-28T15:00:36+00:00","versionOfRecord":{"articleIdentity":"rs-52333","link":"https://doi.org/10.1186/s12879-020-05728-7","journal":{"identity":"bmc-infectious-diseases","isVorOnly":false,"title":"BMC Infectious Diseases"},"publishedOn":"2021-02-24 15:00:28","publishedOnDateReadable":"February 24th, 2021"},"versionCreatedAt":"2021-01-04 21:25:38","video":"","vorDoi":"10.1186/s12879-020-05728-7","vorDoiUrl":"https://doi.org/10.1186/s12879-020-05728-7","workflowStages":[]},"version":"v3","identity":"rs-52333","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-52333","identity":"rs-52333","version":["v3"]},"buildId":"_2-kVJe1T_tPrBINL-cwx","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}