Effectiveness of partial COVID-19 vaccination on the outcome of hospitalized COVID-19 patients during the second pandemic In India

Abstract Background This study investigated the effects of COVID-19 vaccination on the outcome of hospitalized COVID-19 patients. Methods We included COVID-19 patients aged ≥45 years and hospitalized between 1st March to 30th June 2021 at our center. We stratified them into unvaccinated and vaccinated (received one or both doses of vaccine). Results Total 1430 COVID-19 patients (male: 876) were included. Five hundred thirty-six patients (37.5%) received a single vaccine dose, and 43 patients (3%) received two doses before developing COVID-19 disease. The median days of hospital stay of those who survived were ten days (IQR: 8-15). The overall mortality rate, irrespective of vaccination status, was 28.5%. The mortality in the vaccinated was significantly less than the unvaccinated (25.2% vs. 30.7%, p<0.05).The moderate (37.3% vs. 43.4%, P<0.01) and severe (16.8% vs. 21.7%) COVID-19 cases were significantly less in the vaccinated. Conclusion The present study showed even a single dose of COVID-19 vaccination significantly reduces the severity of the disease, mortality, and length of hospitalization.