Proton Pump Inhibitor Omeprazole Alters the Spiking Characteristics of Proteinoids

Proton Pump Inhibitor Omeprazole Alters the Spiking Characteristics of Proteinoids | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Proton Pump Inhibitor Omeprazole Alters the Spiking Characteristics of Proteinoids Panagiotis Mougkogiannis, Andew Adamatzky This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4861305/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This study reveals the significant effect of the proton pump inhibitor omeprazole on the spiking behaviour of proteinoids, leading to a transformative shift in the field of unconventional computing. Through the application of different concentrations of omeprazole, we see a notable modification in the spiking characteristics of proteinoids, including significant alterations in amplitude, frequency, and temporal patterns. By using Boolean logic techniques, we analyse the complex dynamics of the proteinoid-omeprazole system, revealing underlying patterns and connections that question our understanding of biological computing.Our research reveals the unexplored potential of proteinoids as a foundation for unconventional computing. Moreover, our research indicates that the electrical spiking observed in proteinoids may be linked to the movement of protons. This discovery offers new insights into the fundamental mechanisms governing the spiking activity of proteinoids, presenting promising opportunities for future research in this area. Additionally, it opens up possibilities of developing new computational models that exploit the inherent nonlinearity and complexity of biological systems. By combining the effects of omeprazole-induced spikes with Boolean logic, a wide range of opportunities arise for information processing, pattern identification, and problem-solving. This pushes the limits of what can be achieved with bioelectronics. proteinoids omeprazole spiking unconventional computing Boolean logic bioelectronics Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4861305","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":347252360,"identity":"903ca173-c084-4f46-a508-3dfffa70cb3c","order_by":0,"name":"Panagiotis Mougkogiannis","email":"data:image/png;base64,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","orcid":"","institution":"University of the West of England","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Panagiotis","middleName":"","lastName":"Mougkogiannis","suffix":""},{"id":347252361,"identity":"a2389828-3844-4603-903f-77af3b77ee89","order_by":1,"name":"Andew Adamatzky","email":"","orcid":"","institution":"University of the West of England","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Andew","middleName":"","lastName":"Adamatzky","suffix":""}],"badges":[],"createdAt":"2024-08-05 10:34:26","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4861305/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4861305/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":69084021,"identity":"7ab4b136-73e0-4a38-9f47-6e2e17d2882e","added_by":"auto","created_at":"2024-11-15 12:24:33","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":3048381,"visible":true,"origin":"","legend":"","description":"","filename":"ProtonPumpInhibitorOmeprazoleAlterstheSpikingCharacteristicsofProteinoids2.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4861305/v1_covered_170321d8-3df7-4aa7-a9f3-ae6913fe3240.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Proton Pump Inhibitor Omeprazole Alters the Spiking Characteristics of Proteinoids","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"proteinoids, omeprazole, spiking, unconventional computing, Boolean logic, bioelectronics","lastPublishedDoi":"10.21203/rs.3.rs-4861305/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4861305/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":" This study reveals the significant effect of the proton pump inhibitor omeprazole on the spiking behaviour of proteinoids, leading to a transformative shift in the field of unconventional computing. 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