Effect of Dilution of Hyperosmolar Contrast Medium on Characteristics of Pain during Hysterosalpingography

Background: Hyperosomolar contrast media such as Urografin 370 when used in concentrated form during hysterosalpingography (HSG} often provoke pelvic pain. Dilution of such contrast medium should theoretically produce little or no pain after the procedure. Objective: To compare the incidence and duration of painful side effects caused by the use of concentrate and diluted solutions of Urografin, a hyperosmolar contrast medium, during HSG. Method: A randomised double-blind study has been carried out on 140 female patients who underwent HSG for primary infertility during a six months period using an allocation list to concentrated and diluted Urografin solution. Information on the occurrence and severity of pain was obtained from the patient immediately and 48 hours after the procedure. Result: Statistically significant difference (p