Curcumin Loaded Mesoporous Silica Nanoparticles: Its Synthesis, Characterization, and Evaluation

Abstract Curcumin is a safe and natural therapeutic moiety. The aim of the study is to design and develop a molecule containing mesoporous silica nanoparticles loaded with curcumin. Curcumin-loaded mesoporous silica nanoparticles will be evaluated using physicochemical and analytical techniques. Fourier transform infrared analysis confirms the successful incorporation of the curcumin into the mesoporous silica cells, where the quaternary carbon has an absorption band at 1521.22 cm-1 and CH2 at 2858.4 cm-1. X-ray diffraction analysis confirms drug entrapment within the silica nanoparticle as well as there is no extra peak of drug in the final hexagonal channel of the loaded nanoparticle. Scanning electron microscopy and particle size analysis techniques have shown that the size of the unloaded and loaded particles is different. MCM-NPs-C-CUR were successfully synthesized and further research will be conducted to investigate their therapeutic profile.