Cardiac Resynchronization Therapy in a Patient with PR Prolongation and Nonspecific Intraventricular Conduction Delay

Cardiac resynchronization therapy (CRT) improves outcomes in heart failure patients with left bundle branch block (LBBB), but its efficacy in patients with nonspecific intraventricular conduction delay (NICD) and prolonged PR interval remains uncertain. We present a 69-year-old male with NICD who was successfully treated with individualized atrioventricular (AV) delay optimization using SyncAV™ Plus. This approach resulted in QRS narrowing, echocardiographic improvement, and catecholamine withdrawal. The patient remained stable for two years. This case underscores the role of advanced AV delay programming in optimizing CRT outcomes for NICD patients with PR prolongation.