Use of cyanine dyes for the diagnosis of disease associated with angiogenesis

This invention relates to the use of conjugates of cyanine dyes with an angiogenesis specific binding component preferably with an EB-D fibronectin specific binding component for the diagnosis of micrometastasis and small proliferative lesions, in particular primary tumors, precancerosis, dysplasia, metaplasia, endometriosis, ocular diseases associated with angiogenesis, psoriasis, psoriatic arthritis and/or rheumatoid arthritis.