Endometrial Osseous Metaplasia: A Retrospective Analysis and Systematic Review

Olimpia Gabrielli, Giuliana Orlandi, Paolo Toscano, Enrica Di Lella, Antonia Lettieri, Luigi Manzo, Laura Letizia Mazzarelli, Gabriele Ruffo, Carmine Sica, Ferdinando Antonio Gulino, Giosuè Giordano Incognito, Attilio Tuscano, Laura Ieno, Marco Palumbo, Maurizio Guida, Aniello Di Meglio
In: Journal of Clinical Ultrasound · 2025 · vol. 53(9) , pp. 2108–2116 · doi:10.1002/jcu.24085 · PMID:40433757 · W4410829290
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This retrospective analysis and systematic review found that endometrial osseous metaplasia, a rare condition of heterotopic bone in the endometrium, most often affects reproductive-aged women with a history of miscarriage and presents with infertility or menstrual cycle disorders.

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Abstract

Endometrial osseous metaplasia is a rare condition defined as the presence of heterotopic bone in the endometrium. A retrospective, monocentric analysis was conducted, including patients with endometrial osseous metaplasia, and a systematic review of the literature was performed. The retrospective analysis included 10 cases. Most patients (n = 9) were of reproductive age and had a history of miscarriage. The main symptoms were infertility (n = 4) and menstrual cycle disorders (n = 4). The size and the uterine site of the metaplasia varied. It is crucial not to underestimate it, especially in infertile patients with anamnesis of recurrent miscarriages.

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infertility

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References (45)

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