Study on the therapeutic effect of coral calcium hydrogenated, a material that slowly releases hydrogen, on allergic contact dermatitis

Background: Hydrogen has been proven to play a protective role in vivo by its biological effects such as anti-oxidant, anti-inflammatory. Allergic contact dermatitis (ACD) is a common inflammatory skin disease characterized by itching, skin inflammation, and allergic responses. ACD is caused by T cell-mediated delayed type hypersensitivity. Results The aim of this study is to investigate the ameliorative effect of Coral calcium hydrogenated (CCH) which releases hydrogen slowly in the body and has more advantages than the direct use of hydrogen. 2,4-Dinitrochlorobenzene (DNCB) was applied for ACD induction. CCH was applied by intragastric administration. Dermatitis score and number of scratches were significantly diminished in CCH-treated groups. Especially, CCH showed inhibitory effects on skin lesion and hyperplasia. Additionally, splenic coefficient and plasma IgE were significantly inhibited by CCH. Conclusions Those findings suggested CCH has a remarkable effect on DNCB-induced ACD in mice.