EFFECT OF INSULIN RESISTANCE ON THE OCCURRENCE OF PREGNANCY IN WOMEN TREATED EMPIRICALLY FOR UNEXPLAINED INFERTILITY.

Gursoy AF, Aytekin Tokmak, Eroğlu S, Yesilyurt H
Acta endocrinologica (Bucharest, Romania : 2005) · 2017 · doi:10.4183/aeb.2017.314 · PMID:31149193 · PMC6516572
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Insulin resistance, calculated by HOMA-IR, showed no effect on pregnancy occurrence in women undergoing ovulation induction with intrauterine insemination for unexplained infertility.

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This prospective cohort study evaluated whether insulin resistance, assessed using the HOMA-IR index, influenced pregnancy occurrence in women under 35 with unexplained infertility undergoing ovulation induction followed by intrauterine insemination (IUI). Among 173 patients, pregnancy was observed in 37 cycles (21.4%) and not in 136 cycles (78.6%); women who became pregnant had shorter infertility duration and fewer previous cycles, while insulin, fasting glucose, and HOMA-IR levels were similar between groups. The paper concludes that HOMA-IR–defined insulin resistance had no positive or negative effect on pregnancy occurrence under these treatment conditions, with analysis limited to women meeting the unexplained infertility criteria and undergoing this specific OI/IUI approach. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

ContextThe detrimental effects of hyperinsulinemia on human ovaries during follicular development process have been shown in various studies, particularly in women with polycystic ovary syndrome. To our knowledge there is no study regarding the effect of insulin resistance (IR) on the intrauterine insemination (IUI) success in women with unexplained infertility (UEI).ObjectiveTo evaluate the effects of IR on the occurrence of pregnancy among infertile women undergoing ovulation induction (OI) with IUI for UEI.DesignProspective cohort study.Subjects and methods173 patients who met the criteria for UEI and under the age of 35 were included in this study. All women underwent OI with IUI and, subsequently, they were divided into two groups based on the presence of pregnancy. Data reviewed for analysis were demographic, clinical, and laboratory features.ResultsThere were 37 (21.4%) cycles with pregnancy and 136 (78.6%) cycles without pregnancy. Median infertility duration was significantly lower in the pregnant group when compared with non-pregnants (p=0.018). The mean number of previous cycles per patient was also lower in this group (p=0.028). No significant differences were found between the groups in terms of other variables. Levels of insulin, fasting glucose and HOMA-IR were also similar between the two groups.ConclusionsIR calculated by using HOMA-IR index has no positive or negative effect on the occurrence of pregnancy in women undergoing OI therapy with IUI for UEI.
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- Login - Register - Home/Current Issue - About the journal - Editorial board - Online submission - Instructions for authors - Subscriptions - Foundation Acta Endocrinologica - Archive - Contact Romanian Academy The Publishing House of the Romanian Academy ACTA ENDOCRINOLOGICA (BUC) The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List Acta Endocrinologica(Bucharest) is live in PubMed Central Journal Impact Factor - click here. This Article Services Google Scholar PubMed Acta Endocrinologica (Buc) Gursoy AF, Tokmak A, Eroglu S, Yesilyurt H Effect of Insulin Resistance of the Occurence of Pregnancy in Women Treated Empirically for Unexplained Infertility Acta Endo (Buc) 2017, 13 (3): 314-321doi: 10.4183/aeb.2017.314 Context. The detrimental effects of hyperinsulinemia on human ovaries during follicular development process have been shown in various studies, particularly in women with polycystic ovary syndrome. To our knowledge there is no study regarding the effect of insulin resistance (IR) on the intrauterine insemination (IUI) success in women with unexplained infertility (UEI). Objective. To evaluate the effects of IR on the occurrence of pregnancy among infertile women undergoing ovulation induction (OI) with IUI for UEI. Design. Prospective cohort study. Subjects and Methods. 173 patients who met the criteria for UEI and under the age of 35 were included in this study. All women underwent OI with IUI and, subsequently, they were divided into two groups based on the presence of pregnancy. Data reviewed for analysis were demographic, clinical, and laboratory features. Results. There were 37 (21.4%) cycles with pregnancy and 136 (78.6%) cycles without pregnancy. Median infertility duration was significantly lower in the pregnant group when compared with non-pregnants (p=0.018). The mean number of previous cycles per patient was also lower in this group (p=0.028). No significant differences were found between the groups in terms of other variables. Levels of insulin, fasting glucose and HOMA-IR were also similar between the two groups. Conclusions. IR calculated by using HOMA-IR index has no positive or negative effect on the occurrence of pregnancy in women undergoing OI therapy with IUI for UEI. Keywords: HOMA-IR, intrauterine insemination, unexplained infertility, ovulation induction, pregnancy Correspondence: Aytekin Tokmak MD, Zekai Tahir Burak Women’s Health Education and Research Hospital, Talatpasa Bulvari, Hamamönü, Altindag/Ankara 06230, Turkey, E-mail: [email protected]

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