Tegumentary Leishmaniasis: Perspectives and Challenges in This Enigmatic Disease

Tegumentary Leishmaniasis: Perspectives and Challenges in This Enigmatic Disease | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 22 January 2025 V1 Latest version Share on Tegumentary Leishmaniasis: Perspectives and Challenges in This Enigmatic Disease Authors : Héctor Serrano-Coll 0000-0002-8872-872X [email protected] , Lucero Katherine Aristizábal-Parra , Graciela Olarte , and Carolina Salamanca Leguizamón 0000-0002-4344-0538 Authors Info & Affiliations https://doi.org/10.22541/au.173750917.73467526/v1 246 views 154 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract not-yet-known not-yet-known not-yet-known unknown Cutaneous leishmaniasis is a chronic granulomatous disease affecting the skin and mucous membranes. It is caused by an obligate intracellular protozoan of the genus Leishmania, transmitted through the bite of a female sandfly of the genus Phlebotomus or Lutzomyia. The host immune response plays a crucial role in the development of the clinical form of the disease. An imbalance favoring Th1 and Th17 responses promotes localized cutaneous or mucosal forms, whereas a Th2 response is associated with generalized forms, such as disseminated or diffuse cutaneous leishmaniasis. Currently, medical treatment remains based on pentavalent antimonial compounds, which induce host toxicity, underscoring the need to explore new therapeutic options. Supplementary Material File (legends.docx) Download 12.60 KB File (main manuscript v2.docx) Download 66.21 KB File (table.docx) Download 14.75 KB Information & Authors Information Version history V1 Version 1 22 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords cell mediated immunity humoral immunity immune evasion immunological terms leishmania spp parasite th-2 th1 Authors Affiliations Héctor Serrano-Coll 0000-0002-8872-872X [email protected] Universidad CES Clinica CES View all articles by this author Lucero Katherine Aristizábal-Parra Universidad Industrial de Santander View all articles by this author Graciela Olarte Fundacion Universitaria de San Gil View all articles by this author Carolina Salamanca Leguizamón 0000-0002-4344-0538 Fundacion Universitaria de San Gil View all articles by this author Metrics & Citations Metrics Article Usage 246 views 154 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Héctor Serrano-Coll, Lucero Katherine Aristizábal-Parra, Graciela Olarte, et al. Tegumentary Leishmaniasis: Perspectives and Challenges in This Enigmatic Disease. Authorea . 22 January 2025. 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