The association between coagulation/fibrinolysis function and serum lipid levels in people with advanced knee osteoarthritis: a cross-sectional study

Background: . The aim of this study was to explore the relationship between coagulation/fibrinolysis function and serum lipid levels in people with advanced knee osteoarthritis (KOA). Methods: . From January 1st 2013 to January 1st 2018, a total of 206 patients underwent total or unicompartmental knee arthroplasty in Changzhou No.1 People’s Hospital were enrolled consecutively in this study. Baseline characteristics and preoperative laboratory indicators of patients were collected. The association between coagulation/fibrinolysis function and serum lipid levels was analyzed using Spearman correlation analysis and multiple linear regression. Results: . Spearman correlation analysis revealed that coagulation/fibrinolysis function was associated with serum lipid levels, especially prothrombin time was moderately negatively correlated with Apolipoprotein-A1 (r=-0.4585, P<0.05). The multiple linear regression analyses were performed with serum lipid levels as the independent variables and coagulation/fibrinolysis function parameters as the dependent variables after adjusting for sex, age, body mass index, hypertension, diabetes mellitus and coronary heart disease. We found that the regression analysis was reliable (its imitation degree was ideal, adjusted R^2 = 0.3108) and predictive (P<0.0001) when the dependent variable was prothrombin time. The significant contributors to prothrombin time were triglyceride (P<0.001), high density lipoprotein cholesterol (P=0.003), Apolipoprotein-A1 (P=0.017) and Lipoprotein (a) (P=0.015). Conclusions: . The results of this study showed that coagulation/fibrinolysis function was correlated with serum lipid levels in patients with advanced KOA, although the correlation may be small. It may be hypothesized that strategies for lipid control may help improve coagulation/fibrinolytic dysfunction in patients with KOA. Trial registration. This clinical study was retrospectively registered in a publicly available registry because this study was a retrospective study began in 2018. This study was approved by the Ethics Committee of the Third Affiliated Hospital of Soochow University in Jiangsu Province of China (No.CZYY2021187).