Serum Lipoprotein Changes in Female Rats Treated with Progesterone or Synthetic Gestagens Alone or in Combination with Estradiol. I. Total and Fractionated Cholesterol and Lipoprotein Pattern

Rosemarie Tkocz, H. G. Hillesheim, Gerlinde Schmidt, Hermann Hoffmann
In: Experimental and Clinical Endocrinology & Diabetes · 2009 · vol. 91(03) , pp. 319–326 · doi:10.1055/s-0029-1210764 · PMID:3251771 · W2021089272
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Synthetic gestagens altered rat serum cholesterol by reducing HDL-C and LDL-C, while progesterone and chlormadinone acetate did not decrease these lipids but partially reversed estradiol's enhancing effect.

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This study investigated how progesterone and several synthetic gestagens (norethisterone acetate, levonorgestrel, dienogest, and chlormadinone acetate), administered alone at two oral doses or combined with implanted estradiol, affect serum total and fractionated cholesterol and lipoprotein patterns in adult female rats. Using measurements of HDL-C, LDL-C, and VLDL-C and agarose gel electrophoresis, the authors found that nortestosterone-derived gestagens lowered total cholesterol by reducing HDL-C and LDL-C, and that this reduction persisted even in rats pretreated with estradiol; estradiol alone increased these lipids. By contrast, progesterone (P) and chlormadinone acetate (CMA) given alone did not lower total, HDL-C, or LDL-C and only partly reversed estradiol’s effect on HDL-C. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

In adult female rats, the effects of progesterone (P), norethisterone acetate (NEA), levonorgestrel (LNG), dienogest (DEG) and chlormadinone acetate (CMA) given alone at doses of 2.5 or 10 mg/kg p.o. or in combination with s.c. implanted estradiol (E2) on total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C) and very-low-density-lipoprotein cholesterol (VLDL-C) were investigated. Additionally, the lipoprotein pattern was determined using agarose gel electrophoresis. Synthetic gestagens derived from nortestosterone (NEA, LNG, DEG) lowered TC by reduction of HDL-C and LDL-C, whereas E2 induced an increase of these lipids. The decrease of HDL-C and LDL-C caused by the gestagens was also found in E2 pretreated rats. In contrast, the pregnane related CMA and P given alone did not diminish TC, HDL-C or LDL-C. But they partly reversed the enhancing effect of E2 on the HDL-C fraction following their simultaneous administration. The results suggest that the cholesterol lowering effects of gestagens are mediated rather via androgen than via progesterone receptors.
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Subscribe to RSS DOI: 10.1055/s-0029-1210764 © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York Serum Lipoprotein Changes in Female Rats Treated with Progesterone or Synthetic Gestagens Alone or in Combination with Estradiol. I. Total and Fractionated Cholesterol and Lipoprotein Pattern Publication History 1987 Publication Date: 16 July 2009 (online) Summary In adult female rats, the effects of progesterone (P), norethisterone acetate (NEA), levonorgestrel (LNG), dienogest (DEG) and chlormadinone acetate (CMA) given alone at doses of 2.5 or 10 mg/kg p. o. or in combination with s.c. implanted estradiol (E2) on total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C) and very-low-density-lipoprotein cholesterol (VLDL-C) were investigated. Additionally, the lipoprotein pattern was determined using agarose gel electrophoresis. Synthetic gestagens derived from nortestosterone (NEA, LNG, DEG) lowered TC by reduction of HDL-C and LDL-C, whereas E2 induced an increase of these lipids. The decrease of HDL-C and LDL-C caused by the gestagens was also found in E2 pretreated rats. In contrast, the pregnane related CMA and P given alone did not diminish TC, HDL-C or LDL-C. But they partly reversed the enhancing effect of E2 on the HDL-C fraction following their simultaneous administration. The results suggest that the cholesterol lowering effects of gestagens are mediated rather via androgen than via progesterone receptors. Key words Serum lipoproteins - Female rats - Progesterone - Synthetic gestagens - Estradiol

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