Association between polymorphisms (rs1800896, rs1800872, rs1800871) in IL-10 gene with human immunodeficiency virus 1-infected patients’ susceptibility

Background: Interleukin-10 (IL-10) is considered to play a role in the human immunodeficiency virus-1 (HIV-1) infections, and 3 common single nucleotide polymorphisms (SNPs), perhaps have an association with HIV-1 risk. Methods To find out the above doubt, we performed a comprehensive analysis to assess the relationship between IL-10 polymorphisms and HIV-1. The PubMed database were chosen to identify potential articles through Feb 21, 2020. The odds ratio with 95% confidence interval (OR with 95%CI) was calculated to evaluate the strength of the relationships. Results There have 15 different articles including 24 case-control studies including those on three different SNPs in IL-10 for HIV-1 were found. Positive increased or damaged associations were detected for rs1800872C/A with HIV-1 risk in total (such as: OR with 95%CI = 1.22 with 1.02–1.41 for A-allele vs. C-allele model), and Asians (such as: OR with 95%CI = 1.51 with 1.07–1.88 for AA vs. CC model), population-based, PCR-RFLP, sequence subgroups. Moreover, increased associations were also detected between rs1800871C/T SNP (OR with 95%CI = 1.47 with 1.08-2.00 for CC vs. CT + TT model). No association was found for rs1800896. Conclusion Our current study indicated that two SNPs (rs1800872C/A and rs1800871C/T) in IL-10 perhaps be potentially associated with the susceptibility for developing HIV-1 infection.