The status of bone turnover markers in the male patients with osteoporosis

Objective: To observe the change of bone turnover markers in the male patients with osteoporosis. Methods: We retrospectively reviewed the medical records including their original reports of bone mineral density , 25OHD, P1NP and β-CTXin the male patients with osteoporosis treated with bisphosphonates in our hospital between 2013and 2020. Serum 25OHD, P1NP and β-CTX were measured by radioimmunoassay. To study the impact of age on 25OHD, P1NP and β-CTX , the patients were divided into subgroups according to age: <60 yrs、60-69 yrs、70-79 yrs and ≥80 yrs. To study the impact of 25OHDon P1NP and β-CTX, the patients were divided into < 20 ng/ml、20-30 ng/ml and ≥ 30 ng/ml subgroups according to 25OHD level. Comparison of high bone turnover rate was made between the patients with fracture history and patients without fracture history. Results: There were 230 patients. 32 patients were aged <60 yrs, 59 patients were aged 60-69 yrs, 67 patients were aged70-79 yrs and 71 patients were aged ≥80 yrs. Serum 25OHD level was 3-70 ng/ml with average of 29.41±12.48 ng/ml. P1NP level was 11.5-100.8 ng/ml with average of 48.69±20.72 ng/ml. β-CTX level was 0.067-1.91 ng/ml with average of 0.522±0.282 ng/ml. P1NP and /or β-CTX above the upper normal range were present in 47.83% of the patients. The high bone turnover rate was significantly higher in the patients with fracture history than patients without fracture history. There was no impact of age and 25OHD level on the P1NP or β-CTX in our series. Conclusion: High bone turnover was common in male patients with primary osteoporosis.