Effect of mirena on the outcome of frozen embryo transplantation in the treatment of adenomyosis

Objective To investigate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS, Mirena) on adenomyosis and its effect on frozen embryo transfer outcomes. Methods A total of 122 oocytes pick up cycles treated with progestin primed ovarian stimulation (PPOS) + LNG-IUS regimen and 196 cycles treated with PPOS in control group were retrospectively analyzed. The general information, controlled ovary stimulation indexes and clinical outcomes were compared between treatment group and control group. Results There were no significant differences in the general information, number of follicles with diameter > 14 mm at the end of treatment, number of oocytes retrieved, number of mature eggs, the number of normal fertilized eggs, the number of high quality embryos, the total number of effective embryos between the groups (P>0.05). The biochemical pregnancy rate (49.1%), the clinical pregnancy rate (45.1%) and the embryo implantation rate (31.4%) in the treatment group were significantly higher than those in control group (36.7%, 33.5%, 22.4%; P=0.032, 0.037, 0.018). Conclusion The treatment of uterine adenomyosis with Mirena can improve the clinical pregnancy rate and embryo implantation rate of the IVF-ET treatment cycle. It is a new simple, safe and effective assisted reproductive program for adenomyosis. Key words: Adenomyosis; Levonorgestrel-releasing intrauterine system (LNG-IUS); Controlled ovarian stimulation; Frozen-thawed embryo transfer