Vasopressin during abdominal hysterectomy: a randomized controlled trial
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Vasopressin injection into the uterus during abdominal hysterectomy significantly reduced total blood loss by 40% compared to placebo, without increasing surgical complications.
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Abstract
OBJECTIVE: To investigate if the use of vasopressin during abdominal hysterectomy would decrease blood loss. METHODS: Fifty-one patients undergoing abdominal hysterectomy with the diagnosis of leiomyomatous uterus were randomized and received either vasopressin 10 units/10 mL of normal saline or 10 mL of normal saline, injected 5 mL bilaterally, 1 cm medial to the uterine vessels into the lower uterine segment. The sample size was determined assuming a one-third reduction in total blood loss would be clinically relevant. A power analysis determined that 25 patients would be required in each group to assure a power of 0.80, at the.05 significance level. RESULTS: Overall, the two groups were very similar with regard to their demographics, preoperative diagnosis, and relevant findings at the time of surgery. The mean total blood loss in the vasopressin and placebo groups was 445.41 mL and 748.42 mL, respectively. Total blood loss was significantly decreased by 40% in the vasopressin group compared with the placebo group (P <.001). There was no statistically significant difference between the two groups with respect to possible confounding variables or surgical complications. CONCLUSION: Injection of vasopressin into the uterus at the time of abdominal hysterectomy significantly reduces blood loss without increasing morbidity. We have shown that it is a useful adjunct during abdominal hysterectomy.
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Cites (2)
- Complications of abdominal and vaginal hysterectomy among women of reproductive age in the United States 1982
- Novak's Gynecology 1996
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References (13)
- Complications of abdominal and vaginal hysterectomy among women of reproductive age in the United States via openalex
- Novak's Gynecology via openalex
- doi:10.1016/0020-7292(91)90692-x via openalex
- doi:10.1111/j.1471-0528.1994.tb11918.x via openalex
- W2402851910 via openalex
- W2413191547 via openalex
- doi:10.1016/s0140-6736(85)92496-1 via openalex
- doi:10.1016/s0015-0282(16)56392-4 via openalex
- doi:10.1016/s1074-3804(05)80837-0 via openalex
- doi:10.1016/s0140-6736(05)60133-x via openalex
- doi:10.1097/00132586-199508000-00029 via openalex
- doi:10.1016/0029-7844(96)00071-3 via openalex
- doi:10.1016/s0015-0282(16)58523-9 via openalex
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