Nose-only inhalation exposures to alumina nanoparticles / hydrogen chloride gas mixtures induce strong pulmonary pro-inflammatory response | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Nose-only inhalation exposures to alumina nanoparticles / hydrogen chloride gas mixtures induce strong pulmonary pro-inflammatory response Alexandra Bourgois, Dominique Saurat, Alexandre Boyard, Nathalie Guitard, and 11 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-41391/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract The authors have withdrawn this preprint due to author disagreement. Toxicology pulmonary inflammation mixtures nose-only inhalation combustion aerosols alumina nanoparticles hydrogen chloride Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-41391","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":981863,"identity":"d88c71cb-28ff-4197-834b-eb98aec03a0c","order_by":0,"name":"Alexandra Bourgois","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Alexandra","middleName":"","lastName":"Bourgois","suffix":""},{"id":981864,"identity":"53a10957-d806-42fd-8c6c-dec7d7b30846","order_by":1,"name":"Dominique Saurat","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dominique","middleName":"","lastName":"Saurat","suffix":""},{"id":981865,"identity":"20c795ad-ae0e-4d70-93aa-74badb70dd5e","order_by":2,"name":"Alexandre Boyard","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Alexandre","middleName":"","lastName":"Boyard","suffix":""},{"id":981866,"identity":"28edde73-e041-4d43-b483-2adbeeebe687","order_by":3,"name":"Nathalie Guitard","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Nathalie","middleName":"","lastName":"Guitard","suffix":""},{"id":981867,"identity":"12401b46-8751-4d7b-825b-ab32987ac746","order_by":4,"name":"Suzanne De Araujo","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Suzanne","middleName":"","lastName":"De Araujo","suffix":""},{"id":981868,"identity":"7d50a09a-4394-4fc8-bff1-cd1906317960","order_by":5,"name":"Sylvie Renault","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Sylvie","middleName":"","lastName":"Renault","suffix":""},{"id":981869,"identity":"6013f644-2b48-464c-97dc-57fb67a35ec0","order_by":6,"name":"Francisca Fargeau","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Francisca","middleName":"","lastName":"Fargeau","suffix":""},{"id":981870,"identity":"3761df76-eb77-4064-9cc2-a832d0944f68","order_by":7,"name":"Christine Frédéric","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Christine","middleName":"","lastName":"Frédéric","suffix":""},{"id":981871,"identity":"d6cb7919-b701-4d0a-8264-64d82795622f","order_by":8,"name":"Emmanuel Peyret","email":"","orcid":"","institution":"Institut National de l'Environnement et des RISques","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Emmanuel","middleName":"","lastName":"Peyret","suffix":""},{"id":981872,"identity":"b62fd599-476a-4909-aded-e7dab72b0589","order_by":9,"name":"Emmanuel Flahaut","email":"","orcid":"","institution":"Universite Federale Toulouse Midi-Pyrenees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Emmanuel","middleName":"","lastName":"Flahaut","suffix":""},{"id":981873,"identity":"f2d144c3-1ea3-480f-8dac-c07bab62f29c","order_by":10,"name":"Aurélie Servonnet","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Aurélie","middleName":"","lastName":"Servonnet","suffix":""},{"id":981874,"identity":"fca44a3e-c4e6-478d-a377-5e3ff48339ad","order_by":11,"name":"Anne-Laure Favier","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Anne-Laure","middleName":"","lastName":"Favier","suffix":""},{"id":981875,"identity":"07d4340b-c3eb-4ea7-a20e-70f856609ef0","order_by":12,"name":"Ghislaine Lacroix","email":"","orcid":"","institution":"Institut National de l'Environnement industriel et des RISques","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ghislaine","middleName":"","lastName":"Lacroix","suffix":""},{"id":981876,"identity":"d628fb57-a122-4788-8de4-79cf6e06568a","order_by":13,"name":"Sabine François","email":"","orcid":"","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Sabine","middleName":"","lastName":"François","suffix":""},{"id":981877,"identity":"2777c6ac-63d1-4b6f-94fc-e7d21081cca1","order_by":14,"name":"Samir Dekali","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7klEQVRIiWNgGAWjYJCCAwwMzAwSDMwNBz4AeWzsxGthbDg4A6SFmTiLIFqYeSBs/EC+/XTi4QoGaznJ9oONh21+bZPnY2Zg/PAxB7cWgzO5Gw6eYUg3luZJbDic23fbsI2ZgVly5jY8WhiAWhoYDifOYwBp6bnNCNTCxsyLR4t8/1uwlvp5/A8bDlv23LYnqIXhBsSWBGkJoC0MP24nEtRicANki0G64cwZDxsO9jbcTm5jZmzG6xf5/tzNHxsqrOUlzicf/vDjz23b+e3NBz98xOcwaCBAAGMbmGwgpB4Z/CFF8SgYBaNgFIwUAABJ9la9KSOK5gAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0002-9662-0284","institution":"Institut de recherche biomedicale des armees","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Samir","middleName":"","lastName":"Dekali","suffix":""}],"badges":[],"createdAt":"2020-07-13 10:25:32","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-41391/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-41391/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":13518664,"identity":"04138cda-9059-4010-92a7-40d1f8c969bd","added_by":"auto","created_at":"2021-09-17 00:20:46","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":163873,"visible":true,"origin":"","legend":"","description":"","filename":"Theauthorshavewithdrawnthepreprint.pdf","url":"https://assets-eu.researchsquare.com/files/rs-41391/v2_covered.pdf"},{"id":1721860,"identity":"4b30d3bc-4c48-48c4-98c4-2a0c54e4f704","added_by":"auto","created_at":"2020-07-29 18:27:31","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":67786,"visible":true,"origin":"","legend":"","description":"","filename":"Theauthorshavewithdrawnthepreprint.pdf","url":"https://assets-eu.researchsquare.com/files/rs-41391/v2_stamped.pdf"},{"id":1721859,"identity":"c9a7cb4f-7f46-4448-ab1c-3d3448813c24","added_by":"auto","created_at":"2020-07-29 18:27:23","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":36606,"visible":true,"origin":"","legend":"","description":"","filename":"Theauthorshavewithdrawnthepreprint.pdf","url":"https://assets-eu.researchsquare.com/files/rs-41391/v2/Theauthorshavewithdrawnthepreprint.pdf"}],"financialInterests":"","formattedTitle":"Nose-only inhalation exposures to alumina nanoparticles / hydrogen chloride gas mixtures induce strong pulmonary pro-inflammatory response","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":true,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"
[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"pulmonary inflammation, mixtures, nose-only inhalation, combustion aerosols, alumina nanoparticles, hydrogen chloride","lastPublishedDoi":"10.21203/rs.3.rs-41391/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-41391/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe authors have withdrawn this preprint due to author disagreement.\u003c/p\u003e","manuscriptTitle":"Nose-only inhalation exposures to alumina nanoparticles / hydrogen chloride gas mixtures induce strong pulmonary pro-inflammatory response","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-07-29 18:27:23","doi":"10.21203/rs.3.rs-41391/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"
[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-07-22 21:31:02","doi":"10.21203/rs.3.rs-41391/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"
[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"be64a289-168c-4520-baa2-c33ca5374025","owner":[],"postedDate":"July 29th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":191899,"name":"Toxicology"}],"tags":[],"updatedAt":"2020-07-29T18:25:32+00:00","versionOfRecord":[],"versionCreatedAt":"2020-07-29 18:27:23","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-41391","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-41391","identity":"rs-41391","version":["v2"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}
Text is read by the "Ask this paper" AI Q&A widget below.
Extraction quality varies by source — PMC NXML preserves structure
cleanly, OA-HTML may include some navigation residue, and OA-PDF can
have broken hyphenation. The publisher copy
(via DOI)
is the canonical version.