Umbilical Cord Blood CK-MB, Troponin T, ProBNP, IMA Levels, and Fetal Cardiac Function in Cases of IUGR

Abstract Objective: To evaluate umbilical cord blood creatine kinase MB (CK-MB), Troponin T (TnT-hs), pro-brain natriuretic peptide (proBNP), ischemia modified albumin (IMA) levels and fetal cardiac function in intrauterine growth retardation (IUGR). Methods: The study included 39 pregnant women with IUGR and 42 healthy pregnant women in control group. IUGR was diagnosed when estimated fetal weight was <10 percentile. Fetal cardiac function was evaluated by ultrasound in third trimester of pregnancy and compared with control group. Umbilical cord blood biochemical test (CK-MB, TnT-hs, proBNP, IMA) results compared between the groups. Results: In cardiac morphological evaluation, cardiothoracic index was higher and left sphericity index was lower in the IUGR group compared to the control group (p<0,001, p=0,018). Left myocardial performance index (MPI) was higher, tricuspid and mitral annular plane systolic excursion (TAPSE and MAPSE) values were lower in IUGR group than control group (p=0,035, p=0,038 and p=0,011 respectively). In IUGR group only proBNP levels was increased compare to control group in umbilical cord blood biochemical tests (p=0,018). There was negative correalation between umbilical cord blood proBNP levels and MAPSE value (r=-0,332, p=0,002). Conclusions: We observed that IUGR was associated with fetal cardiac morphological changes and systolic dysfunction. Also, in IUGR group cord blood proBNP level was increased and negatively correlated with MAPSE value.