Chronic endometritis: an hidden pathology

Jorge Duro Gómez, Vendrell Aranda Celia María
In: Obstetrics & Gynecology International Journal · 2020 · vol. 11(3) , pp. 155–156 · doi:10.15406/ogij.2020.11.00502 · W4205705387
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Chronic endometritis, often caused by bacteria or Mycoplasma, may involve unculturable pathogens and can be treated with antibiotics to improve endometrial histology and implantation rates.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This mini review describes chronic endometritis as a chronic inflammatory condition of the endometrium, characterized by plasma cells in the stroma, and links its putative infectious basis to diagnostic challenges and infertility outcomes. It reports that pathogens are detected in up to 73.1% of patients, while about 31.7% of endometrial cultures can be negative, and notes major caveats including non-specific ultrasound/analytical markers and under-diagnosis; CD138 immunohistochemistry is presented as a more sensitive method than routine H&E (56% vs. 13%) for detecting plasma cells, with hysteroscopy showing high sensitivity but low specificity (e.g., 98.4% vs. 56.23%). It summarizes proposed antibiotic regimens (e.g., doxycycline and pathogen-directed alternatives) and cites studies reporting improved fertility/implantation metrics after treatment, while also stating that endometritis may persist in some cases and may require post-therapy reassessment. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Infection appears to be the basis of chronic endometritis. Some pathogen is found in up to 73.1% of patients 6 .Common bacteria and Mycoplasma are the most frequently pathogens in chronic endometritis. Although female genital tuberculosis can cause chronic endometritis and infertility, it is anecdotal in industrialized countries and frequently is associated with predisposing factors. he endometrial cultures were negative in about 31.7 % of the cases, probably due to the presence of nocultivable pathogen (like anaerobic bacterias or viruses) Different studies have shown that antibiotic therapy can restore normal endometrial histology, improving the rate of implantation.

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Condition tags

infertilitydisambig:endometritis

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last seen: 2026-06-10T17:14:06.276822+00:00
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