Prevalence trends, population characteristics and treatment outcomes of tuberculosis combined with diabetes in southwest China: a register-based retrospective study

Prevalence trends, population characteristics and treatment outcomes of tuberculosis combined with diabetes in southwest China: a register-based retrospective study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Prevalence trends, population characteristics and treatment outcomes of tuberculosis combined with diabetes in southwest China: a register-based retrospective study Deliang Kong, Yichao Shui, Ting Zhang, Xiangliu Wang, Chengguo Wu, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4627535/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The global situation regarding the prevention and control of pulmonary tuberculosis (PTB) remains challenging. With the ongoing aging population and the increasing prevalence of chronic diseases, the epidemic of comorbid PTB and diabetes mellitus (PTB-DM) presents challenges to PTB control .This study aims to explore the epidemiological trends of PTB-DM in Southwest China and identify risk factors associated with adverse treatment outcomes, providing evidence to enhance TB prevention and control measures and improve patient treatment outcomes.This retrospective study used PTB case data from the PTB Information Management System within the China Information System for Disease Control and Prevention (CISDP). The trend in PTB-DM incidence was analyzed using the Joinpoint regression model, and population and clinical characteristics of patients were described using frequencies (n) and percentages. Group comparisons utilized chi-square tests, and risk factors for adverse treatment outcomes were explored using multivariable logistic regression models with stepwise backward selection based on Wald tests.The Joinpoint analysis revealed a declining trend in PTB incidence in Southwest China (AAPC = -10.22%, 95% CI: -11.49%~-8.94%), contrasting with a rapid increase in PTB-DM incidence (AAPC = 14.25%, 95% CI: 11.35% ~17.23%). The proportion of PTB-DM among PTB cases increased significantly from 2.96% to 12.28%, indicating a pronounced increase in the comorbidity prevalence of PTB-DM. PTB-DM patients were characterized by a higher proportion of males and elderly individuals, multiple positive aetiological results, and lower rates of proactive medical consultation. Among PTB-DM patients, successful outcomes accounted for 80.85% , while unsuccessful outcomes accounted for 19.15%.Although the number of PTB-DM patients with successful treatment outcomes increased overall (AAPC = 12.22%, 95% CI: 10.30% ~14.16%), the failure rate showed a gradual upward trend (AAPC = 14.18%, 95% CI: 6.53% ~27.67%). Analysis of factors associated with adverse treatment outcomes showed that advanced age, retreatment, referral, and positive aetiological results were risk factors for PTB-DM patients.Therefore, it is imperative to strengthen early screening and standardized treatment for key populations, such as the elderly population, and to implement more comprehensive and effective treatment and management measures for patients. Health sciences/Medical research/Epidemiology Health sciences/Diseases/Respiratory tract diseases Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryMaterial.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4627535","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":326703610,"identity":"30e71c85-9095-4f33-916c-db1167c7facb","order_by":0,"name":"Deliang Kong","email":"","orcid":"","institution":"Chongqing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Deliang","middleName":"","lastName":"Kong","suffix":""},{"id":326703612,"identity":"2db4e657-db05-458e-b439-d4f9307285a7","order_by":1,"name":"Yichao Shui","email":"","orcid":"","institution":"Chongqing Medical 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With the ongoing aging population and the increasing prevalence of chronic diseases, the epidemic of comorbid PTB and diabetes mellitus (PTB-DM) presents challenges to PTB control .This study aims to explore the epidemiological trends of PTB-DM in Southwest China and identify risk factors associated with adverse treatment outcomes, providing evidence to enhance TB prevention and control measures and improve patient treatment outcomes.This retrospective study used PTB case data from the PTB Information Management System within the China Information System for Disease Control and Prevention (CISDP). The trend in PTB-DM incidence was analyzed using the Joinpoint regression model, and population and clinical characteristics of patients were described using frequencies (n) and percentages. 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