The effect of a novel antibody-based drug Prospekta on brain electrical activity in mice

The effect of a novel antibody-based drug Prospekta on brain electrical activity in mice | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 21 May 2025 V1 Latest version Share on The effect of a novel antibody-based drug Prospekta on brain electrical activity in mice Authors : Elena Kardash 0000-0001-8005-4209 [email protected] , Marina Kabirova , Denis Gorobets , Dilorom Begmatova , Izhak Michaelevski 0000-0002-0783-1443 , Albert Pinhasov 0000-0001-8116-4565 , Nataliya Petrova , Ksenia Ganina , Sergey Tarasov , and Oleg Epstein Authors Info & Affiliations https://doi.org/10.22541/au.174781841.17856545/v1 323 views 113 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Affinity-purified antibody to S100 calcium binding protein B that has undergone gradual technological processing and was additionally modified with an electromagnetic signal is an active pharmaceutical substance of a novel drug Prospekta. Earlier studies have shown that the drug possesses a wide range of pharmacological properties, not limited to pro-cognitive and anxiolytic activity. Here, we aimed to determine the effect of Prospekta on the baseline electrical activity of the mouse brain. Extradural electrodes were surgically implanted into the skull of adult male socially submissive mice. Mice were orally administered Prospekta or purified water as a control via gavage for 5 days starting from the end of the recovery period. Brain baseline activity was recorded during 5 min after placing animals into arena. Quantitative measures of EEG delta (1–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), beta (13–30 Hz), and gamma (30–100 Hz) power were assessed. It was shown that the drug led to a decrease in theta and alpha band power in the left prefrontal cortex. Furthermore, the drug exhibited a tendency to influence the coherence of electrical activity between the left prefrontal cortex and the right hippocampus, resulting in a moderate phase shift across all examined brain regions. At the same time, no prominent changes in EEG activity were observed in the right hippocampal region. We show that Prospekta modifies EEG parameters of animals and thereby confirm that the drug mechanism of action is based on its ability to affect functional (electrophysiological) brain activity. Supplementary Material File (manuscript.docx) Download 89.51 KB Information & Authors Information Version history V1 Version 1 21 May 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords electrophysiological recording post-vibration activity s100 calcium binding protein b vibrational iterations Authors Affiliations Elena Kardash 0000-0001-8005-4209 [email protected] OOO “NPF “MATERIA MEDICA HOLDING” View all articles by this author Marina Kabirova Ariel University View all articles by this author Denis Gorobets Ariel University View all articles by this author Dilorom Begmatova Ariel University View all articles by this author Izhak Michaelevski 0000-0002-0783-1443 Ariel University Faculty of Natural Sciences View all articles by this author Albert Pinhasov 0000-0001-8116-4565 Ariel University View all articles by this author Nataliya Petrova OOO "NPF "MATERIA MEDICA HOLDING" View all articles by this author Ksenia Ganina OOO "NPF "MATERIA MEDICA HOLDING" View all articles by this author Sergey Tarasov OOO "NPF "MATERIA MEDICA HOLDING" View all articles by this author Oleg Epstein OOO “NPF “MATERIA MEDICA HOLDING” View all articles by this author Metrics & Citations Metrics Article Usage 323 views 113 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Elena Kardash, Marina Kabirova, Denis Gorobets, et al. The effect of a novel antibody-based drug Prospekta on brain electrical activity in mice. Authorea . 21 May 2025. DOI: https://doi.org/10.22541/au.174781841.17856545/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); Cited by Kirill Svitkin, Elizaveta Morozova, Anna Krasheninnikova, Elena Kardash, Ksenia Ganina, Alexandra Emelyanova, Sergey Tarasov, Oleg Epstein, Effect of Frequency of Prospekta Administration: Anxiolytic Effect in Wistar Rats, Dose-Response, 23 , 2, (2025). https://doi.org/10.1177/15593258251346841 Crossref Loading... View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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