Towards Unmanned Proteomics Data Generation: A Fully Automated Sample-to-Data System for Proteomic Experiments

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This paper describes a fully automated sample-to-data system for high-throughput proteomic experiments, demonstrated for spatial proteomics and profiling of plasma and cell lines.

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Abstract

Summary The π-HuB project requires proteomic measurements of millions of low-input samples that are challenging with current technology. Here, we introduce a pilot π-HuB data factory that features a fully automated sample-to-data system to enable high-throughput digitization of human samples. Our platform, as a proof-of-concept towards unmanned proteomics, was demonstrated to show longitudinal robustness and applied for spatial proteomics and the profiling of plasma and cell lines, thereby serving as the workhorse to drive π-HuB.

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europepmc
last seen: 2026-05-20T01:45:00.602351+00:00
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