Survival analysis of patients with oral squamous cell carcinoma treated by radical surgery for the first time

 Objective: To investigate the five-year overall survival (OS) rate and postoperative survival time of patients with oral squamous cell carcinoma (OSCC), and to analyze the clinical and pathological factors affecting the survival of patients with OSCC. Methods: : We collected the data of patients with OSCC received radical surgical treatment for the first time in the department of maxillofacial surgery of the first affiliated hospital of Chongqing medical university from Apr. 2015 to Dec 2016.Follow-up was conducted until March 2022. Results: : A total of 68 patients were included in this study.Tongue (35.3%) was the most common part, followed by cheek (30.9%).The 5-year OS rate was 55.9%, about 52.9% of OSCC patients had recurrence and metastasis after surgery, and the 5-year overall disease-free survival rate was 42.6%. The univariate analysis showed that clinical stage, size of tumor, lymph node metastasis (pN), pathological differentiation and recurrence and metastasis were the exposure factors affecting survival time ( p <0.05). Multivariate analysis showed that drinking, pathological differentiation and recurrence and metastasis were independent factors affecting survival time ( P <0.05). Another special finding was that 4 patients with OSCC were found to suffer from esophageal squamous cell carcinoma (ESCC) within 1-4 years after surgery. Conclusion: The survival prognosis of patients with OSCC is correlated with clinical stage, size of tumor, lymph node metastasis (pN), pathological differentiation, recurrence and metastasis. drinking, pathological differentiation and recurrence and metastasis were independent factors affecting survival time. Clinical screening of esophageal squamous cell carcinoma may be performed routinely in OSCC patients with a history of alcohol and tobacco. Mini Abstract: The survival prognosis of patients with OSCC is correlated with clinical stage, size of tumor, lymph node metastasis (pN), pathological differentiation, recurrence and metastasis.