Ultrasound guided sclerotherapy with medical ethanol and polycinnamol for treatment of ovarian endometriosis cysts

To evaluate the therapeutic effects of ultrasound-guided medical ethanol combined with polycinnamol sclerosis in the treatment of ovarian endometriosis cysts.

From September 2016 to May 2018, eighty-eight patients (106 cysts) with ovarian endometriosis cyst sclerotherapy guided by ultrasound in the fourth affiliated Hospital of Harbin Medical University were enrolled in this study.According to the different application of sclerosing agent, they were divided into medical ethanol group (control group) with a total of 53 lesions in 44 cases and medical ethanol combined with polycinnamol group (observation group) with a total of 53 lesions. The cure rate and total effective rate of the two groups were calculated at 3 months and 6 months after treatment, and the difference of curative effect between the two groups was compared.The level of CA125 before and after treatment and the incidence of adverse reactions during and after treatment were compared and analyzed.

Three months after treatment, the cure rate of the medical ethanol group was 79.2%, the cure rate of the combined group was 73.6%, the total effective rate was 100%, the difference of the two groups was not significant (P>0.05), the cure rate of the medical ethanol group was 96.2% in 6 months after the treatment, and the cure rate of the combined group was 92.5%. The total effective rate was 100% and the difference of the two groups was not significant (P>0.05). The levels of serum carbohydrate antigen CA125 in the two groups decreased significantly at 3 months after treatment, which were significantly different from those before treatment (t≤6.13, 8.39, P<0.001). The serum CA125 levels in the medical ethanol group and the combined group did not decrease to the normal level. The level of serum CA125 in the two groups decreased to the normal range 6 months after treatment, which was significantly different from that before treatment (t≥5.86, 8.76, P0.05).The incidence of abdominal pain and drunken adverse reactions in the combined group was significantly lower than that in the medical ethanol group (P<0.05), and there was no fever in the two groups, and the incidence of adverse reactions to fever in the combined group was significantly higher than that in the medical ethanol group on the 3rd and 7th day after treatment, but there was no significant difference (P>0.05).

Ultrasound guided interventional therapy of medical ethanol combined with polyvinyl alcohol has the same curative effect as medical ethanol alone, and the incidence of adverse reactions is low. For patients with ethanol allergy and pain sensitivity, the treatment method of medical ethanol hardening and flushing combined with polyvinyl alcohol retention is better than that of medical ethanol alone. | 1 | Hsieh CL, Shiau CS, Lo LM, et a1. Effectiveness of ultrasound-guided aspiration and sclerotherapy with 95% ethano1 for treatment of recurrent ovarian endometriomas [J]. Fertil Steril, 2009, 91(6): 2709-2713. | | 2 | Wang LL, Dong XQ, Shao XH, et a1.Ultrasound-guided interventionaltherapy for recurrent ovarian chocolate cysts [J]. Ultrasound Med Biol, 2011, 37(10): 1596-1602. | | 3 | 刘红敏, 邹云飞, 宋誉民, 等. 彩超引导下置管抽液医用乙醇冲洗联合聚桂醇硬化治疗肝肾囊肿疗效观察 [J]. 中国超声医学杂志, 2017, 33(8): 749-751. | | 4 | Rabe E, Breu F, Cavezzi A, et al. European guidelines for sclerotherapy in chronic venous disorders [J]. 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