STATUS OF THE LIPID PEROXIDATION SYSTEM IN ADENOMYOSA

STATUS OF THE LIPID PEROXIDATION SYSTEM IN ADENOMYOSA DOI: https://doi.org/10.36074/grail-of-science.20.06.2025.107Keywords: adenomyosis, pelvic pain, lipid peroxidation, oxidative stressSummary Adenomyosis (A) is a pressing problem in modern gynecology. This is a chronic disease with a progressive and relapsing course, which is accompanied by pelvic pain syndrome, impaired menstrual and reproductive functions, and affects the mental health of women. Purpose of work: to determine the role of peroxidation products and oxidative stress in the pathogenesis of adenomyosis. Materials and research methods. 37 women of reproductive age with a diagnosis of A (main group) were under observation, whose diagnosis and management were carried out in accordance with current legislation, consistent with the guidelines of the European Society of Human Reproduction and Embryology (ESHRE, 2022) and in accordance with the guidelines of the Guideline Development Group (GDG, 2022). The control group included 30 healthy women. We determined the indicators of the state of lipid peroxidation (LPO) processes: malondialdehyde and diene conjugates. Pain was assessed using the Visual Analogue Scale (VAS). Statistical processing of the obtained data was carried out using the standard StatSoft Statistsca for Windows 13.0 software package. The results. Unlike healthy women, the content of DC increases with the increase in stage A: in stage I - 1.6 times (p*<0.05), in stage II - 1.9 times (p*<0.05) and in stage III - 2.4 times (p*<0.05). It was found that there is a high correlation between the severity of A and the content of DC (r=+0.73; p<0.01). A similar pattern is observed when determining the MDA content. The MDA content in women with A upon admission to the hospital showed that at stage I of the disease the level increases by 1.3 times (p*>0.05), at stage II - by 1.7 (p*<0.001), at stage III - by almost 2 times (p*<0.001) compared to healthy women. Conclusions. Patients with adenomyosis have an imbalance in the lipid peroxidation system, and therefore oxidative stress can be considered as one of the pathophysiological links of the disease. The conducted studies showed that adenomyosis is characterized by intensification of free radical oxidation with the accumulation of its highly toxic products, the level of activity of these processes correlates with the stage of adenomyosis (r= +0.75; p<0.05). 200 to 2 000 characters. Downloads Downloads License Copyright (c) 2025 Halyna Semenyna, Iryna Mandziy, Tetiana Fartushok, Marta Doroshenko-Kravchyk References Giudice, L.C., Kao, L.C. (2014). Endometriosis. Lancet, 364(9447), 1789-99. https://doi.org/10.1016/S0140-6736(04)17403-5. DOI: https://doi.org/10.1016/S0140-6736(04)17403-5 de Dominique, Z., Bruno, B., Charles, C. (2020). Endometriosis and infertility: pathophysiology and management. Lancet, 376, 730-8. https://doi.org/10.1016/S0140-6736(10)60490-4. 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