Fertility, pregnancy and neonatal outcomes of patients with adenomyosis: a systematic review and meta-analysis

Konstantinos Nirgianakis, Kalaitzopoulos, Dimitrios R, Kohl Schwartz, Alexandra Sabrina, Spaanderman, Marc, Kramer, Boris W, Mueller, Michael D, Mueller, Martin
2021 · doi:10.5167/uzh-198389 · W6910943168
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This systematic review and meta-analysis found that adenomyosis is associated with lower clinical pregnancy rates and higher miscarriage rates after assisted reproductive technology treatment.

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This systematic review and meta-analysis examined how adenomyosis affects fertility, pregnancy, and neonatal outcomes, using electronic searches of MEDLINE, PubMed, and Cochrane databases up to April 2020 to include 17 observational studies. Across included evidence limited to treatment with assisted reproductive technology (ART), adenomyosis was associated with a lower clinical pregnancy rate (OR 0.69, 95% CI 0.51–0.94) and a higher miscarriage rate (OR 2.17, 95% CI 1.25–3.79). A major limitation is that the included studies were observational rather than randomized, as reflected by the study design used for eligibility. This paper is centrally about adenomyosis — specifically its associations with fertility, pregnancy, and neonatal outcomes in the context of ART.

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Abstract

Abstract

Abstract

This study aimed to investigate the association of adenomyosis with fertility, pregnancy and neonatal outcomes. An electronic search was conducted using the MEDLINE, PubMed and Cochrane databases up to April 2020. Seventeen observational studies were included. Adenomyosis was significantly associated with a lower clinical pregnancy rate (odds ratio [OR] 0.69; 95% confidence interval [CI] 0.51-0.94) and higher miscarriage rate (OR 2.17; 95% CI 1.25-3.79) after treatment with assisted reproductive technology (ART). The lower clinical pr Additional indexing Creators (Authors) Volume Volume Volume Number Number Number Page range/Item number Page range/Item number Page range/Item number Page end Page end Page end Item Type Item Type Item Type In collections Dewey Decimal Classifikation Dewey Decimal Classifikation Dewey Decimal Classifikation

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Language Language Language Publication date Publication date Publication date Date available Date available Date available ISSN or e-ISSN ISSN or e-ISSN ISSN or e-ISSN OA Status OA Status OA Status Publisher DOI Citations Nirgianakis, K., Kalaitzopoulos, D. R., Kohl Schwartz, A. S., Spaanderman, M., Kramer, B. W., Mueller, M. D., & Mueller, M. (2021). Fertility, pregnancy and neonatal outcomes of patients with adenomyosis: a systematic review and meta-analysis. Reproductive Biomedicine Online, 42, 185–206. https://doi.org/10.1016/j.rbmo.2020.09.023

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adenomyosis

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