Effects of prostaglandins on the production of collagenase by rabbit uterine cervical fibroblasts

H Goshowaki, Hideko Goshowaki, A Ito, Akira Itô, Y Mori, Yo Mori
Prostaglandins · 1988 · vol. 36(1) , pp. 107–114 · doi:10.1016/0090-6980(88)90106-2 · PMID:2845482 · W1978969556
Lab / animal OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-09-03 ⓘ

Exogenous prostaglandin E2 and PGF2 alpha stimulated collagenase production by rabbit uterine cervical fibroblasts, suggesting their role in cervical ripening rather than endogenous prostaglandins.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Effects of prostaglandins on the production of collagenase by rabbit uterine cervical fibroblasts were investigated. Exogenous prostaglandin E2 (PGE2) and PGF2 alpha significantly stimulated the production of collagenase in a dose dependent manner, whereas PGI2 did not. Addition of arachidonic acid in the presence of absence of indomethacin to the cell culture did not show any increase in collagenase production. Recombinant human interleukin-1 (rhIL-1) also promoted the production of cervical collagenase independently of endogenous prostaglandin(s). Furthermore both exogenous PGE2 and PGF2 alpha enhanced the rhIL-1-induced collagenase production whereas PGI2 and/or indomethacin did not. These results suggested that exogenous PGE2 and PGF2 alpha but not endogenous prostaglandin(s) participate in cervical ripening and dilation by enhancing collagenase production by rabbit uterine cervical cells.

My notes (saved in your browser only)

MeSH descriptors

Cervix Uteri Microbial Collagenase Prostaglandins Animals Arachidonic Acid Arachidonic Acids Arachidonic Acids Cervix Uteri Cervix Uteri Dinoprost Dinoprost Dinoprostone Dinoprostone Dose-Response Relationship, Drug Female Fibroblasts Fibroblasts Indomethacin Indomethacin Interleukin-1

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

References (21)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:19:42.633400+00:00
unpaywall
last seen: 2026-10-28T06:33:34.531809+00:00
License: CC0 · commercial use OK