OP08.07: The research of the influence of uterine artery embolisation on functional ovarian reserve

To evaluate ovarian reserve of fertile women after uterine artery embolisation (UAE) to define possible influence of the intervention on ovary function. Prospective observation for 1 year of 80 fertile patients with myoma and/or adenomyosis, treated with UAE including ultrasonography (US), the serum level of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and estradiol (E2) on 3–4 day of menstrual cycle. Taking into account possible age-conditioned differences in the initial ovarian reserve, the patients were divided into 2 groups: 1—aged 20–35 (average 30.2) (n = 32); 2—aged 36–44 (average 39.5) (n = 48). UAE of all patients was considered successful both clinically and according to ultrasound data. In 6 months after UAE significant enlargement of ovary on 3–4 day of menstrual cycle (5.1 ± 1.2/8.3 ± 1.2 ml P < 0.05) associated with presence of larger antral follicles. After the year of observation the ovary volume reduced (6.7 ± 1.2/5.1 ± 1.2 ml) with no significant difference from initial data noted in both groups. At the same period the follicular size was normal in the 1st group, in the 2nd group the maximal size of the follicles exceeded 9 mm (significant difference from the initial data P < 0.05). Initially the hormone level in both groups was normal. In 6 months the level of AMH in both groups reduced, but the difference was insignificant with no changes in FSH and E2 levels. By the end of the observation the hormone level didn't change in the 1st group, in the 2nd group was registered a reduction of AMH level remaining in the range of age norm, but significantly lower than initial (1.98 ± 0.57/1.02 ± 0.30 ng/ml P < 0.05). The influence of UAE on ovary function of fertile patients cannot be ruled out, the risk of reduction of ovarian reserve increases in the older age group.