Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template
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OA: closed
CC-BY-NC-ND-4.0
Abstract
The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6- O -acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
- last seen: 2026-06-05T02:00:03.366016+00:00
License: CC-BY-NC-ND-4.0