Predictors and Risk Factors for the Development of Cardiovascular Disease among Tuberculosis Patients

Predictors and Risk Factors for the Development of Cardiovascular Disease among Tuberculosis Patients | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Predictors and Risk Factors for the Development of Cardiovascular Disease among Tuberculosis Patients Bheesham Kingrani, Amer Hayat Khan, Sabariah Noor Harun, Ali Qureshi, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7149197/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Introduction: Globally, the morbidity burden of tuberculosis and cardiovascular disease (CVD) is substantial in developing nations. A significant epidemiological and pathological co-occurrence exists between tuberculosis (TB) and CVD. A contributory relationship between tuberculosis infection and cardiovascular disease is evident. Beyond traditional risk factors such as diabetes mellitus, hypertension, and hyperlipidemia, additional risk factors, predictive indicators, and clinical markers contribute to cardiovascular disease development in tuberculosis patients. Monocytes, macrophages, lymphocytes, and cytokines, which are integral to cell-mediated immune responses against Mycobacterium tuberculosis , are also key drivers of atherosclerotic processes in the cardiovascular vasculature. Methodology: This retrospective cohort study was conducted from January 2023 to August 2023, utilizing data collected from January 2015 to December 2022. The study sought to identify risk factors and predictive indicators for the development of cardiovascular disease (CVD) among individuals with a diagnosis and screening of active tuberculosis (TB). A descriptive, retrospective research design was employed, focusing on TB patients without pre-existing CVD. A convenience sample of 402 TB patient records was included in this analysis. Results This study's findings suggest a strong correlation between clinical markers, including high-sensitivity troponin T, C-reactive protein, electrocardiographic data, echocardiographic findings, cardiac enzymes, acute kidney injury (AKI), diabetes mellitus (DM), anaemia, and severe chest radiographic abnormalities, and the development of cardiovascular disease in tuberculosis patients. Positive values for the aforementioned clinical parameters were considered indicative of cardiovascular disease development. Conclusions The results advance understanding of a potential correlation between Mycobacterium tuberculosis infection and the development of cardiovascular disease, examining the risk factors conducive to CVD pathogenesis, and facilitating the development of targeted interventions to improve the comprehensive care of individuals with tuberculosis. Epidemiology Infectious Diseases Cardiac & Cardiovascular Systems Development of cardiovascular disease pulmonary tuberculosis extra-pulmonary tuberculosis Mycobacterium tuberculosis cardiac enzymes C-reactive protein troponin-t (Hs) anaemia chronic kidney disease acute kidney infection hypertension diabetes mellitus Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7149197","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":489611820,"identity":"2fd51ddf-ad5d-475e-a690-bae7b7105647","order_by":0,"name":"Bheesham 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mellitus","lastPublishedDoi":"10.21203/rs.3.rs-7149197/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7149197/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eIntroduction:\u003c/h2\u003e\u003cp\u003eGlobally, the morbidity burden of tuberculosis and cardiovascular disease (CVD) is substantial in developing nations. A significant epidemiological and pathological co-occurrence exists between tuberculosis (TB) and CVD. A contributory relationship between tuberculosis infection and cardiovascular disease is evident. Beyond traditional risk factors such as diabetes mellitus, hypertension, and hyperlipidemia, additional risk factors, predictive indicators, and clinical markers contribute to cardiovascular disease development in tuberculosis patients. Monocytes, macrophages, lymphocytes, and cytokines, which are integral to cell-mediated immune responses against \u003cem\u003eMycobacterium tuberculosis\u003c/em\u003e, are also key drivers of atherosclerotic processes in the cardiovascular vasculature.\u003c/p\u003e\u003ch2\u003eMethodology:\u003c/h2\u003e\u003cp\u003eThis retrospective cohort study was conducted from January 2023 to August 2023, utilizing data collected from January 2015 to December 2022. The study sought to identify risk factors and predictive indicators for the development of cardiovascular disease (CVD) among individuals with a diagnosis and screening of active tuberculosis (TB). A descriptive, retrospective research design was employed, focusing on TB patients without pre-existing CVD. A convenience sample of 402 TB patient records was included in this analysis.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eThis study's findings suggest a strong correlation between clinical markers, including high-sensitivity troponin T, C-reactive protein, electrocardiographic data, echocardiographic findings, cardiac enzymes, acute kidney injury (AKI), diabetes mellitus (DM), anaemia, and severe chest radiographic abnormalities, and the development of cardiovascular disease in tuberculosis patients. 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