Magneto-Mechanical Nanotherapy for Adiposopathy: Targeting Lipid Metabolism and Inflammation

not-yet-known not-yet-known not-yet-known unknown Obesity has reached critical levels worldwide, driving comorbidities like type 2 diabetes, hypertension, dyslipidemia, and cardiovascular diseases. These conditions stem from adiposopathy, a pathological alteration of adipose tissue caused by hypercaloric diets and sedentary lifestyles. Current treatments, including pharmacotherapy and bariatric surgery, are limited by side effects, invasiveness, and poor patient compliance, highlighting the urgent need for alternative therapies targeting adiposopathy. In this study, we explore a novel magneto-mechanical treatment (MMT) using functionalized magnetic nanoparticles (MNPs) to induce mechanical stress in adipose tissue cells via a low-frequency alternating magnetic field (LF-AMF). We synthesized octahedral Fe3O4 MNPs through thermal decomposition and functionalized them with meso-2,3-dimercaptosuccinic acid (DMSA) and chitosan (CHITO) to enhance biocompatibility. The effects of MMT were evaluated on macrophages and adipocytes—key players in adiposopathy—using a custom-built LF-AMF device operating below 100 Hz. We demonstrate that MMT induces cellular damage in macrophages, reactive oxygen species (ROS) production, and inhibited cell proliferation and inflammation. In adipocytes, MMT promotes lipolysis, reducing fat storage and restoring physiological differentiation. These results suggest that MMT can modulate adipose tissue composition and function, offering a promising non-invasive approach to treating adiposopathy. Further studies are needed to elucidate the molecular mechanisms and optimize therapeutic application. Supplementary Material File (ahm manuscript.docx) - Download - 22.57 MB Information & Authors Information Version history Copyright This work is licensed under a Non Exclusive No Reuse License.

Authors Metrics & Citations Metrics Article Usage 316views 134downloads Citations Download citation Anna Laurenzana, Martin Albino, Giorgia Papini, et al. Magneto-Mechanical Nanotherapy for Adiposopathy: Targeting Lipid Metabolism and Inflammation. Authorea. 03 June 2025. DOI: https://doi.org/10.22541/au.174893059.92149721/v1 DOI: https://doi.org/10.22541/au.174893059.92149721/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu.